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Remodeling of lymph vessels in the fibrotic lesion of bronchioloalveolar cell carcinoma

Research Project

Project/Area Number 21590619
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Laboratory medicine
Research InstitutionShinshu University

Principal Investigator

HONDA Takayuki  信州大学, 医学部, 教授 (80238815)

Co-Investigator(Kenkyū-buntansha) UEHARA Takeshi  信州大学, 医学部, 講師 (80402121)
Project Period (FY) 2009 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2009: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywords肺癌 / 肺腺癌 / リンパ管 / リンパ管侵襲 / 腺癌 / 肺 / 気管支肺胞上皮癌 / 線維化
Research Abstract

The aim of this study is to clear three-dimensional morphological changes of lymphatic vessels in a progression of BAC. In the normal alveolar region, they straightly elongated without bifurcation and most of them were compressed. In the central portion of the fibrotic lesion, the density of lymph vessels was higher and the lumens were wider. The lymph vessels morphologically changed to a tank. As the BAC advances forming central fibrosis, the volume ratio of the lymph vessels to the whole one of the cancer will become larger, and probability of carcinoma cell invasion to the lymph vessels will increase.

Report

(4 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • 2009 Annual Research Report
  • Research Products

    (10 results)

All 2011 2010 2009

All Journal Article (10 results) (of which Peer Reviewed: 10 results)

  • [Journal Article] Different efficacy of CT screening for lung cancer according to histological type : Analysis of Japanese-smoker cases detected using a low-dose CT screen2011

    • Author(s)
      Kondo R, Yoshida K, Kawakami S, Shiina T, Kurai M, Takasuna K, Yamamoto H, Koizumi T, Honda T, Kubo K
    • Journal Title

      Lung Cancer

      Volume: 74 Issue: 3 Pages: 433-440

    • DOI

      10.1016/j.lungcan.2011.05.006

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Relationship between mitochondria and the development of specific lipid droplets in capillary endothelial cells of the respiratory tract in patients withsarcoidosis2011

    • Author(s)
      Mochizuki I, Kubo K, Honda T
    • Journal Title

      Mitochondrion

      Volume: 11 Issue: 4 Pages: 601-606

    • DOI

      10.1016/j.mito.2011.03.009

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Comparative study of three different catheters for CT imaging-bronchoscopy-guided radiofrequency ablation as a potential and novelinterventional therapy for lung cancer2011

    • Author(s)
      Tanabe T, Koizumi T, Tsushima K, Ito M, Kanda S, Kobayashi T, Yasuo M, Yamazaki Y, Kubo K, Honda T, Kondo R, Yoshida K
    • Journal Title

      Chest

      Volume: 137 Pages: 890-897

    • URL

      http://chestjournal.chestpubs.org/content/137/4/890.long

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Malignant hepatic epithelioid hemangioendothelioma withrapid progression and fatal outcome2010

    • Author(s)
      Komatsu Y, Koizumi T, Yasuo M, Urushihata K, Yamamoto H, Hanaoka M, Kubo K, Kawakami S, Honda T, Fujimoto K, Hachiya T
    • Journal Title

      Intern Med

      Pages: 1149-1153

    • NAID

      130000251644

    • URL

      https://www.jstage.jst.go.jp/article/internalmedicine/49/12/49_12_1149/_pdf

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Comparative study of three different catheters for CT imaging-bronchoscopy-guided radiofrequency ablation as a potential and novel interventional therapy for lung cancer2010

    • Author(s)
      Tanabe T, Koizumi T, Tsushima K, Ito M, Kanda S, Kobayashi T,Yasuo M, Yamazaki Y, Kubo K, Honda T, Kondo R, Yoshida K.
    • Journal Title

      Chest

      Volume: 137 Pages: 890-897

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Malignant hepatic epithelioid hemangioendothelioma with rapid progression and fatal outcome.2010

    • Author(s)
      Komatsu Y, Koizumi T, Yasuo M, Urushihata K, Yamamoto H, Hanaoka M, Kubo K, Kawakami S, Honda T, Fujimoto K, Hachiya T.
    • Journal Title

      Intern Med

      Volume: 49 Pages: 1149-1153

    • NAID

      130000251644

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] HRCT features of small perihperal lung carcinomas detected in a low-dose CT screening program2010

    • Author(s)
      Sone S, Honda T, 他
    • Journal Title

      Acad Radiol 17

      Pages: 75-83

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] HRCT features of small peripheral lung carcinomas detected in a low-dose CT screening program2009

    • Author(s)
      Sone S, Matsumoto T, Honda T, Tsushima K, Takayama F, Hanaoka T, Kondo R, Haniuda M
    • Journal Title

      Acad Radiol

      Volume: 17 Pages: 75-83

    • URL

      http://www.sciencedirect.com/science/article/pii/S1076633209004474

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] A novel device(SD-101)with high accuracy for screening sleep apnoeahypopnoea syndrome.2009

    • Author(s)
      Agatsuma T, Honda T, 他
    • Journal Title

      Respirology 14

      Pages: 1143-1150

    • NAID

      120007110416

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Analysis of plasmin generation and clot lysis of plasma fibrinogen purified from a heterozygous dysfibrinogenemia, BbetaGly15Cys(Hamamatsu II)2009

    • Author(s)
      Kamijyo Y, Honda T, 他
    • Journal Title

      Blood Coagul Fibrinolysis 20

      Pages: 726-732

    • NAID

      120007110410

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed

URL: 

Published: 2009-04-01   Modified: 2016-04-21  

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