Development of epigenetic factors for the prognosis of autoimmune thyroid disease using monozygotic twins

• Project/Area Number: 21590625
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Laboratory medicine
• Research Institution: Osaka University
• Principal Investigator: WATANABE Mikio 大阪大学, 大学院・医学系研究科, 助教 (50294088)
• Co-Investigator(Renkei-kenkyūsha): HAYAKAWA Kazuo 大阪大学, 大学院・医学系研究科, 教授 (70142594)
• Project Period (FY): 2009 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
• Keywords: 病態予後 / 自己免疫疾患 / 遺伝子多型 / エピジェネティクス / メチル化 / 一塩基多型 / バセドウ病 / 橋本病 / DNAメチル化 / 双生児

Research Abstract

We have collected genomic DNA samples from patients with autoimmune thyroid diseases who were strictly classified into categories depend on their prognosis, and also from monozygotic twin pairs. We have clarified the associations of some functional polymorphisms in immune regulatory genes with the prognosis of Graves' and Hashimoto' s diseases. In addition, we have reported for the first time that the global methylation of genomic DNA was related to the genotype of polymorphism in DNMT1 gene, which also associated with the prognosis of autoimmune thyroid diseases.

Research Products

• [Journal Article] Prolonged hybridization with a cRNA probe improves the signal to noise ratio for in-tube in situ hybridization for quantification of mRNA after fluorescence-activated cell sorting (2012)
  • Author(s): Yamada, H., Yamakawa, N., Watanabe, M., Hidaka, Y., Iwatani, Y., Takano, T.
  • Journal Title: Biotech Histochem Volume: (in press) Issue: 5 Pages: 366-71
  • DOI: 10.3109/10520295.2012.672650
  • Peer Reviewed
• [Journal Article] Functional polymorphisms in TBX21 and HLX are associated with development and prognosis of Graves' disease (2011)
  • Author(s): Morita, M., Watanabe, M., Inoue, N., Inaoka, C., Akamizu, T., Tatsumi, K., Hidaka, Y., Iwatani, Y.
  • Journal Title: Autoimmunity Volume: 45(2) Issue: 2 Pages: 129-36
  • DOI: 10.3109/08916934.2011.622013
  • Peer Reviewed
• [Journal Article] Association of functional GITR gene polymorphisms related to expression of GITR molecules with prognosis of autoimmune thyroid disease (2011)
  • Author(s): Tomizawa, R., Watanabe, M., Inoue N., Takemura, K., Hidaka, Y., Akamizu, T., Hayakawa, K., Iwatani, Y.
  • Journal Title: Clin Exp Immunol Volume: 165(2) Issue: 2 Pages: 141-147
  • DOI: 10.1111/j.1365-2249.2011.04414.x
  • Peer Reviewed
• [Journal Article] Association of functional polymorphisms in promoter regions of IL5, IL6, and IL13 genes with development and prognosis of autoimmune thyroid diseases (2011)
  • Author(s): Inoue, N., Watanabe, M., Morita, M., Tatsumi, K., Hidaka, Y., Akamizu, T., Iwatani, Y.
  • Journal Title: ClinExp Immunol Volume: 163(3) Issue: 3 Pages: 318-23
  • DOI: 10.1111/j.1365-2249.2010.04306.x
  • Peer Reviewed
• [Journal Article] mRNA quantification after fluorescence activated cell sorting using locked nucleic acid probes (2011)
  • Author(s): Maruo, R., Yamada, H., Watanabe, M., Hidaka, Y., Iwatani, Y. Takano, T.
  • Journal Title: Mol Biotechnol Volume: 49(1) Issue: 1 Pages: 42-47
  • DOI: 10.1007/s12033-011-9375-9
  • Peer Reviewed
• [Journal Article] Transcriptional activity of the 5'-flanking region of the thyroid transcription factor-1 gene in human thyroid cell lines (2011)
  • Author(s): Yamada, H., Takano, T., Matsuzuka, F., Watanabe, M., Miyauchi, A., Iwatani, Y.
  • Journal Title: Genet Mol Biol Volume: 34(1) Issue: 1 Pages: 6-10
  • DOI: 10.1590/s1415-47572010005000109
  • Peer Reviewed
• [Journal Article] Association of functional polymorphisms in promoter regions of IL5, IL6, and IL13 genes with development and prognosis of autoimmune thyroid diseases. (2011)
  • Author(s): Inoue, N., Watanabe, M., Morita, M., Tatsumi, K., Hidaka, Y., Akamizu, T., Iwatani, Y.
  • Journal Title: Clinical and Experimental Immunology Volume: (印刷中)
  • Peer Reviewed
• [Journal Article] mRNA quantification after fluorescence activated cell sorting using locked nucleic acid probes. (2011)
  • Author(s): Maruo, R., Yamada, H., Watanabe, M., Hidaka, Y., Iwatani, Y.Takano, T.
  • Journal Title: Mol Biotechnol Volume: (印刷中)
  • Peer Reviewed
• [Journal Article] Transcriptional activity of the 5'-flanking region of the thyroid transcription factor-1 gene in human thyroid cell lines. (2011)
  • Author(s): Yamada, H., Takano, T., Matsuzuka, F., Watanabe, M., Miyauchi, A., Iwatani, Y.
  • Journal Title: Genet Mol Biol Volume: (印刷中)
  • Peer Reviewed
• [Journal Article] Association of functional polymorphisms related to the transcriptional level of FOXP3 with prognosis of autoimmune thyroid diseases (2010)
  • Author(s): Inoue, N., Watanabe, M., Morita, M., Tomizawa, R., Akamizu, T., Tatsumi, K., Hidaka, Y., Iwatani, Y.
  • Journal Title: ClinExpImmunol Volume: 162(3) Issue: 3 Pages: 402-406
  • DOI: 10.1111/j.1365-2249.2010.04229.x
  • Peer Reviewed
• [Journal Article] Messenger RNA quantification after fluorescence activated cell sorting using in situ hybridization (2010)
  • Author(s): Yamada, H., Maruo, R., Watanabe, M., Hidaka, Y., Iwatani, Y., Takano, T.
  • Journal Title: Cytometry Part A Volume: 77(11) Issue: 11 Pages: 1032-1037
  • DOI: 10.1002/cyto.a.20973
  • Peer Reviewed
• [Journal Article] Messenger RNA quantification after fluorescence activated cell sorting using intracellular antigens (2010)
  • Author(s): Yamada, H., Maruo, R., Watanabe, M., Hidaka, Y., Iwatani, Y., Takano, T.
  • Journal Title: Biochem BiophysResCommun Volume: 397(3) Issue: 3 Pages: 425-428
  • DOI: 10.1016/j.bbrc.2010.05.112
  • Peer Reviewed
• [Journal Article] Increases in urinary creatinine and blood pressure during early pregnancy in preeclampsia (2010)
  • Author(s): Kuromoto, K., Watanabe, M., Adachi, K., Ohashi, K., Iwatani, Y.
  • Journal Title: Ann Clin Biochem Volume: 47(Pt 4) Issue: 4 Pages: 336-342
  • DOI: 10.1258/acb.2010.090290
  • Peer Reviewed
• [Journal Article] Postpartum increase of serum thioredoxin concentrations and the relation to CD8 lymphocytes (2010)
  • Author(s): Kuroda, S., Watanabe, M., Santo, T., Shimizuishi, Y., Takano, T., Hidaka, Y., Kimura, T., Iwatani, Y.
  • Journal Title: Ann Clin Biochem Volume: 47(Pt 1) Issue: 1 Pages: 62-66
  • DOI: 10.1258/acb.2009.009120
  • Peer Reviewed
• [Journal Article] Association of functional polymorphisms related to the transcriptional level of FOXP3 with prognosis of autoimmune thyroid diseases. (2010)
  • Author(s): Inoue, N., Watanabe, M., Morita, M., Tomizawa, R., Akamizu, T., Tatsumi, K., Hidaka, Y., Iwatani, Y.
  • Journal Title: Clinical and Experimental Immunology Volume: 162 Pages: 402-406
  • Peer Reviewed
• [Journal Article] Messenger RNA quantification after fluorescence activated cell sorting using in situ hybridization. (2010)
  • Author(s): Yamada, H., Maruo, R., Watanabe, M., Hidaka, Y., Iwatani, Y., Takano, T.
  • Journal Title: Cytometry Part A Volume: 77 Pages: 1032-1037
  • Peer Reviewed
• [Journal Article] Messenger RNA quantification after fluorescence activated cell sorting using intracellular antigens. (2010)
  • Author(s): Yamada, H., Maruo, R., Watanabe, M., Hidaka, Y., Iwatani, Y., Takano, T
  • Journal Title: Biochem Biophys Res Commun. Volume: 397 Pages: 425-428
  • Peer Reviewed
• [Journal Article] Increases in urinary creatinine and blood pressure during early pregnancy in preeclampsia. (2010)
  • Author(s): Kuromoto, K., Watanabe, M, Adachi, K., Ohashi, K., Iwatani, Y.
  • Journal Title: Annals of Clinical Biochemistry Volume: 47 Pages: 336-342
  • Peer Reviewed
• [Journal Article] Postpartum increase of serum thioredoxin concentrations and the relation to CD8 lymphocytes (2010)
  • Author(s): Kuroda S, Watanabe M, Santo T, Shimizuishi Y, Takano T, Hidaka Y, Kimura T, Iwatani Y.
  • Journal Title: Annals of Clinical Biochemistry 47 Pages: 62-66
  • Peer Reviewed
• [Journal Article] Association of-31C/ T functional polymorphism in the interleukin-1beta gene with the intractability of Graves' disease and the proportion of Th17 cells (2009)
  • Author(s): Hayashi, F., Watanabe, M., Nanba, T., Inoue, N., Akamizu, T., Iwatani, Y.
  • Journal Title: Clin Exp Immunol Volume: 158(3) Issue: 3 Pages: 281-286
  • DOI: 10.1111/j.1365-2249.2009.04034.x
  • Peer Reviewed
• [Journal Article] Increases of the Th1/ Th2 cell ratio in severe Hashimoto' s disease and in the proportion of Th17 cells in intractable Graves' disease (2009)
  • Author(s): Nanba, T., Watanabe, M., Inoue, N., Iwatani, Y.
  • Journal Title: Thyroid Volume: 19(5) Issue: 5 Pages: 495-501
  • DOI: 10.1089/thy.2008.0423
  • Peer Reviewed
• [Journal Article] Involvement of functional polymorphisms in the TNFAgene in the pathogenesis of autoimmune thyroid diseases and production of anti-TSH receptor antibody (2009)
  • Author(s): Inoue, N., Watanabe, M., Nanba, T., Wada, M., Akamizu, T., Iwatani, Y.
  • Journal Title: Clin Exp Immunol Volume: 156(2) Issue: 2 Pages: 199-204
  • DOI: 10.1111/j.1365-2249.2009.03884.x
  • Peer Reviewed
• [Journal Article] Expression of nestin mRNA is a differentiation marker in thyroid tumors (2009)
  • Author(s): Yamada H., Takano, T., Ito, Y., Matsuzuka, F., Miya, A., Kobayashi, K., Yoshida, H., Watanabe, M., Iwatani, Y., Miyauchi, A.
  • Journal Title: Cancer Lett Volume: 280(1) Issue: 1 Pages: 61-64
  • DOI: 10.1016/j.canlet.2009.02.006
  • Peer Reviewed
• [Journal Article] Association of -31C/T functional polymorphism in the interleukin-1β gene with the intractability of Graves' disease and the proportion of Th17 cells (2009)
  • Author(s): Hayashi, F., Watanabe, M., Nanba, T., Inoue, N., Akamizu, T., Iwatani, Y.
  • Journal Title: Clinical and Experimental Immunology 158 Pages: 281-286
  • Peer Reviewed
• [Journal Article] Increases of the Th1/Th2 cell ratio in severe Hashimoto's disease and in the proportion of Th17 cells in intractable Graves' disease (2009)
  • Author(s): Nanba, T., Watanabe, M., Inoue, N., Iwatani, Y.
  • Journal Title: Thyroid 19 Pages: 495-501
  • Peer Reviewed
• [Journal Article] Involvement of functional polymorphisms in the TNFA gene in the pathogenesis of autoimmune thyroid diseases and production of anti-TSH receptor antibody (2009)
  • Author(s): Inoue, N., Watanabe, M., Nanba, T., Wada, M., Akamizu, T., Iwatani, Y.
  • Journal Title: Clinical and Experimental Immunology 156 Pages: 199-204
  • Peer Reviewed
• [Journal Article] Early detection of metastasis and relapse of colorectal cancer by recognizing NCA-2 in commercially available CEA assay (2009)
  • Author(s): Hanada, H., Mugii, S, Takeoka, K., Maeda, I, Watanabe, M., Hidaka, Y., Iwatani, Y.
  • Journal Title: Clinical Chemistry 55 Pages: 1747-1751
  • Peer Reviewed
• [Journal Article] Clinical utility and characteristics of nine anti-HCV antibody screening reagents used in Japan (2009)
  • Author(s): Kita, M., Deguchi, M., Kagita, M., Yoshioka, N., Kobayashi, E., Watanabe, M., Asari, S., Yamanaka, K., Iwatani, Y.
  • Journal Title: Clinical Laboratory 55 Pages: 9-22
  • Peer Reviewed
• [Journal Article] Expression of nestin mRNA is a differentiation marker in thyroid tumors (2009)
  • Author(s): Yamada H., Takano, T., Ito, Y., Matsuzuka, F., Miya, A., Kobayashi, K., Yoshida, H., Watanabe, M., Iwatani, Y., Miyauchi, A.
  • Journal Title: Cancer Letter 280 Pages: 61-64
  • Peer Reviewed
• [Presentation] DNMT1, 3a, 3b遺伝子の多型と自己免疫性甲状腺疾患の病態およびゲノムのメチル化率との関連 (2011)
  • Author(s): 荒川裕也、渡邉幹夫、井上直哉、日高洋、巽圭太、岩谷良則
  • Organizer: 第54回日本甲状腺学会学術集会(大阪)
  • Place of Presentation: 大阪
  • Year and Date: 2011-11-23
• [Presentation] ケモカイン遺伝子の機能的多型と自己免疫性甲状腺疾患の病態との関連 (2011)
  • Author(s): 赤羽舞子、渡邉幹夫、井上直哉、日高洋、巽圭太、岩谷良則
  • Organizer: 第54回日本甲状腺学会学術集会
  • Place of Presentation: 大阪国際交流センター
  • Year and Date: 2011-11-23
• [Presentation] DNMT1,3a,3b遺伝子の多型と自己免疫性甲状腺疾患の病態およびゲノムのメチル化率との関連 (2011)
  • Author(s): 荒川裕也、渡邉幹夫、井上直哉、日高洋、巽圭太、岩谷良則
  • Organizer: 第54回日本甲状腺学会学術集会
  • Place of Presentation: 大阪国際交流センター
  • Year and Date: 2011-11-23
• [Presentation] MIR329 rs72561778A/G多型と自己免疫性甲状腺疾患との関連 (2011)
  • Author(s): 武村和哉、渡邉幹夫、澁谷さやか、日高洋、巽圭太、岩谷良則
  • Organizer: 第58回日本臨床検査医学会学術集会
  • Place of Presentation: 岡山コンベンションセンター
  • Year and Date: 2011-11-18
• [Presentation] IL-5,IL-6,IL-13遺伝子プロモータ領域の多型と自己免疫性甲状腺疾患の病態予後との関連 (2011)
  • Author(s): 渡邉幹夫、井上直哉、森田麻美、巽圭太、日高洋、赤水尚史、岩谷良則
  • Organizer: 第18回日本遺伝子診療学会大会[遺伝医学合同学術集会2011]
  • Place of Presentation: 京都大学
  • Year and Date: 2011-06-18
• [Presentation] IL-16及びMCP-1遺伝子の機能的多型と自己免疫性甲状腺疾 患の病態予後との関連 (2010)
  • Author(s): 赤羽舞子、渡邉幹夫、井上直哉、日高洋、巽圭太、赤水尚史、岩谷良則
  • Organizer: 第53回日本臨床検査医学会近畿支部総会
  • Place of Presentation: 奈良
  • Year and Date: 2010-12-12
• [Presentation] DNMT1の遺伝子多型と自己免疫性甲状腺疾患の病態予後との関連、第53回日本臨床検査医学会近畿支部総会 (2010)
  • Author(s): 荒川裕也、渡邉幹夫、日高洋、巽圭太、赤水尚史、岩谷良則
  • Organizer: 第53回日本臨床検査医学会近畿支部総会
  • Place of Presentation: 奈良
  • Year and Date: 2010-12-12
• [Presentation] IL21R-4610C/T多型の機能と自己免疫性甲状腺疾患との関連 (2010)
  • Author(s): 武村和哉、渡邉幹夫、延原崇之、赤水尚史、日高洋、岩谷良則
  • Organizer: 第53回日本臨床検査医学会近畿支部総会
  • Place of Presentation: 奈良
  • Year and Date: 2010-12-12
• [Presentation] GITR遺伝子多型と自己免疫性甲状腺疾患の難治度・重症度との関連 (2010)
  • Author(s): 武村和哉、富澤理恵、渡邉幹夫、井上直哉、早川和生、赤水尚史、日高洋、岩谷良則
  • Organizer: 第50回日本臨床化学会年次学術集会
  • Place of Presentation: 甲府
  • Year and Date: 2010-09-23
• [Presentation] Measuring TFF3/LGALS3 mRNA ratio in FNABS from thyroid nodule : a clinical trial of eighty cases.14th International Thyroid Congress (ITC), Paris, Sept.11-16, 2010 (2010)
  • Author(s): Yamada, H., Takano, T., Kihara, M., Hirokawa, M., Yoshida, H., Watanabe, M., Hidaka, Y., Iwatani, Y., Miyauchi, A.
  • Organizer: 14th International Thyroid Congress
  • Place of Presentation: Paris, France
  • Year and Date: 2010-09-15
• [Presentation] Association of functional polymorphisms related to the transcriptional level of FOXP3 gene with prognosis of autoimmune thyroid diseases (2010)
  • Author(s): Watanabe, M., Inoue, N., Morita, M., Tomizawa, R., Akamizu, T., Tatsumi, K., Hidaka, Y., Iwatani, Y.
  • Organizer: 14th International Thyroid Congress(ITC)
  • Place of Presentation: Paris
  • Year and Date: 2010-09-13
• [Presentation] Measuring TFF3/ LGALS3 mRNA ratio in FNABS from thyroid nodule : a clinical trial of eighty cases (2010)
  • Author(s): Yamada, H., Takano, T., Kihara, M., Hirokawa, M., Yoshida, H., Watanabe, M., Hidaka, Y., Iwatani, Y., Miyauchi, A.
  • Organizer: 14th International Thyroid Congress(ITC)
  • Place of Presentation: Paris
  • Year and Date: 2010-09-13
• [Presentation] Association of functional polymorphisms related to the transcriptional level of FOXP3 gene with prognosis of autoimmune thyroid diseases (2010)
  • Author(s): Watanabe, M., Inoue, N., Morita, M., Tomizawa, R., Akamizu, T., Tatsumi, K., Hidaka, Y., lwatani, Y
  • Organizer: 14th International Thyroid Congress
  • Place of Presentation: Paris, France
  • Year and Date: 2010-09-13
• [Presentation] 自己免疫性甲状腺疾患の難治性および重症度とTBX21遺伝子多型との関連 (2010)
  • Author(s): 森田麻美、井上直哉、渡邉幹夫、日高洋、巽圭太、赤水尚史、岩谷良則
  • Organizer: 第57回日本臨床検査医学会学術集会
  • Place of Presentation: 東京
  • Year and Date: 2010-09-11
• [Presentation] FOXP3遺伝子の機能的多型による個体差と自己免疫性甲状腺疾患の予後との関連 (2010)
  • Author(s): 渡邉幹夫, 井上直哉、森田麻美、富澤理恵、赤水尚史、巽圭太、日高洋、岩谷良則
  • Organizer: 第17回日本遺伝子診療学会大会
  • Place of Presentation: 津
  • Year and Date: 2010-08-06
• [Presentation] Preoperative diagnosis of thyroid nodules by measuresing TFF3/ LGALS3 mRNA(T/ G) ratio : A clinical trial of fifty cases (2010)
  • Author(s): Yamada, H., Takano, T., Kihara, M., Hirokawa, M., Yoshida, H., Watanabe, M., Iwatani, Y., Hidaka, Y., Miyauchi, A.
  • Organizer: 14th International Congress of Endocrinology(ICE)
  • Place of Presentation: Kyoto
  • Year and Date: 2010-03-29
• [Presentation] Increases of the Th1/ Th2 cell ratio in severe Hashimoto' s disease and in the proportion of Th17 cells in intractable Graves' disease (2010)
  • Author(s): Watanabe, M., Nanba, T., Inoue, N., Iwatani, Y.
  • Organizer: 14th International Congress of Endocrinology(ICE)
  • Place of Presentation: Kyoto
  • Year and Date: 2010-03-28
• [Presentation] 自己免疫性甲状腺疾患の難治性・重症度とGITR遺伝子多型との関連 (2009)
  • Author(s): 冨澤理恵, 井上直哉, 渡邉幹夫, 赤水尚史, 早川和生, 岩谷良則
  • Organizer: 第49回近畿医学検査学会・第52回日本臨床検査医学会近畿支部総会合同学会
  • Place of Presentation: 京都
  • Year and Date: 2009-11-29
• [Presentation] バセドウ病患者における甲状腺内IFN-γ、IL-4及びIL-17発現細胞の割合 (2009)
  • Author(s): 延原崇之, 林文明, 渡邉幹夫, 井上直哉, 高村勇貴, 松塚文夫, 宮内昭, 岩谷良則
  • Organizer: 第49回近畿医学検査学会・第52回日本臨床検査医学会近畿支部総会合同学会
  • Place of Presentation: 京都
  • Year and Date: 2009-11-29
• [Presentation] IL1B遺伝子-31C/T多型がバセドウ病の難治性とTh17細胞比率に及ぼす影響 (2009)
  • Author(s): 渡邉幹夫, 林文明, 南波崇, 井上直哉, 赤水尚史, 岩谷良則
  • Organizer: 第37回日本臨床免疫学会総会ワークショップ
  • Place of Presentation: 東京
  • Year and Date: 2009-11-13
• [Presentation] Involvement of the functional polymorphisms in TNFA gene in the pathogenesis of autoimmune thyroid diseases and the production of anti-TSH receptor antibody (2009)
  • Author(s): Inoue, N., Watanabe, M., Nanba, T., Akamizu, T., Iwatani, Y.
  • Organizer: 9th Congress of the Asia and Oceania Thyroid Association(AOTA)
  • Place of Presentation: Nagoya
  • Year and Date: 2009-11-03
• [Presentation] Expression of nestin mRNA is a differentiation marker in thyroid tumors (2009)
  • Author(s): Yamada, H., Takano, T., Ito, Y., Matsuzuka, F., Miya, A., Kobayashi, K., Yoshida, H., Watanabe, M., Iwatani, Y., Miyauchi, A.
  • Organizer: 9th Congress of the Asia and Oceania Thyroid Association(AOTA)
  • Place of Presentation: Nagoya
  • Year and Date: 2009-11-03
• [Presentation] An in-tube in situ hybridization method for the novel stem cell detection system, FACS-mQ (2009)
  • Author(s): Maruo, R., Yamada, H., Takano T., Watanabe, M., Iwatani, Y., Hidaka, Y.
  • Organizer: 9th Congress of the Asia and Oceania Thyroid Association(AOTA)
  • Place of Presentation: Nagoya
  • Year and Date: 2009-11-03
• [Presentation] Involvement of the functional polymorphisms in TNFA gene in the pathogenesis of autoimmune thyroid diseases and the production of anti-TSH receptor antibody (2009)
  • Author(s): 井上直哉, 渡邉幹夫, 南波崇, 赤水尚史, 岩谷良則
  • Organizer: 9th Congress of the Asia and Oceania Thyroid Association (AOTA)
  • Place of Presentation: Nagoya, JAPAN
  • Year and Date: 2009-10-03
• [Presentation] Expression of nestin mRNA is a differentiation marker in thyroid tumors (2009)
  • Author(s): Yamada, H., Takano, T., Ito, Y., Matsuzuka, F., Miya, A., Kobayashi, K., Yoshida, H., Watanabe, M., Iwatani, Y., Miyauchi, A.
  • Organizer: 9th Congress of the Asia and Oceania Thyroid Association (AOTA)
  • Place of Presentation: Nagoya, JAPAN
  • Year and Date: 2009-10-03
• [Presentation] An in-tube in situ hybridization method for the novel stem cell detection system, FACS-mQ (2009)
  • Author(s): Maruo, R., Yamada, H., Takano T., Watanabe, M., Iwatani, Y., Hidaka, Y.
  • Organizer: 9th Congress of the Asia and Oceania Thyroid Association (AOTA)
  • Place of Presentation: Nagoya, JAPAN
  • Year and Date: 2009-10-03
• [Presentation] Association of the -31C/T functional polymorphism in the interleukin-1β gene with the intractability of Graves' disease and the proportion of Th17 cells (2009)
  • Author(s): 渡邉幹夫, 林文明, 南波崇, 井上直哉, 赤水尚史, 岩谷良則
  • Organizer: 80th Annual Meeting of the American Thyroid Association
  • Place of Presentation: Palm Beach, USA
  • Year and Date: 2009-09-26
• [Presentation] Association of the-31C/ T functional polymorphism in the interleukin-1βgene with the intractability of Graves' disease and the proportion of Th17 cells (2009)
  • Author(s): Watanabe, M., Hayashi, F., Nanba, T., Inoue, N., Akamizu, T., Iwatani, Y.
  • Organizer: 80th Annual Meeting of the American Thyroid Association
  • Place of Presentation: Palm Beach
  • Year and Date: 2009-09-25
• [Presentation] 自己免疫性甲状腺疾患の予後とIL-17遺伝子の機能的多型との関連 (2009)
  • Author(s): 渡邉幹夫, 中口あづさ, 南波崇, 延原崇之, 林文明, 赤水尚史, 岩谷良則
  • Organizer: 第56回日本臨床検査医学会学術集会
  • Place of Presentation: 札幌
  • Year and Date: 2009-08-28
• [Presentation] TNF-α遺伝子多型と自己免疫性甲状腺疾患の病態との関連 (2009)
  • Author(s): 井上直哉, 渡邉幹夫, 南波崇, 赤水尚史, 岩谷良則
  • Organizer: 第56回日本臨床検査医学会学術集会
  • Place of Presentation: 札幌
  • Year and Date: 2009-08-28
• [Book] 遺伝子検査学実習書(臨床検査学実習書シリーズ) (2010)
  • Author(s): 渡邉幹夫
  • Publisher: 医歯薬出版
• [Remarks]
  • URL: http://sahswww.med.osaka-u.ac.jp/~prevdiag/
• [Remarks]
• [Remarks]
  • URL: http://sahswww.med.osaka-u.ac.jp/
• [Remarks]
  • URL: http://sahswww.med.osaka-u.ac.jp/