Regulatory Network for Expression of Antibiotic Tolerance in Pseudomonas aeruginosa
| Project/Area Number |
21590627
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Laboratory medicine
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| Research Institution | The University of Tokushima |
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Principal Investigator |
ONO Tsuneko 徳島大学, 大学院・ヘルスバイオサイエンス研究部, 教授 (40035514)
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| Co-Investigator(Kenkyū-buntansha) |
MIYAKE Yoichiro 徳島大学, 大学院・ヘルスバイオサイエンス研究部, 教授 (80136093)
MURAKAMI Keiji 徳島大学, 大学院・ヘルスバイオサイエンス研究部, 助教 (10335804)
KUWAHARA Tomomi 徳島大学, 大学院・ヘルスバイオサイエンス研究部, 准教授 (60263810)
TETSUYA Yoshinaga 徳島大学, 大学院・ヘルスバイオサイエンス研究部, 教授 (40220694)
SHIZUO Kayama 徳島大学, 大学院・ヘルスバイオサイエンス研究部, 助教 (50432761)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2011: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2010: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2009: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
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| Keywords | 緑膿菌 / バイオフィルム感染症 / 抗菌薬抵抗性 / rpoS / rpoN / quorum sensing / PQS / c-di-GMP / カルバペネム / バイオフィルム / pslオペロン / cbrA / psl / RSCV / wspF / 付着 |
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| Research Abstract |
It has been suggested that lasR, lasI and rpoS genes of Pseudomonas aeruginosa involved in ofloxacin tolerance and the tolerance induced in Las quorum sensing system was regulated by rpoS gene. Conversely, rpoN gene and PQS quorum sensing genes, pqsA, pqsE, and pqsR, negatively affected the antibiotic tolerance. In addition, we have isolated 14 and 11 mutants decreased antibiotic tolerance in adherent cells and in biofilm cells, respectively.
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Report
(4 results)
Research Products
(30 results)
