Elucidation of molecular mechanisms of drug-resistant leukemia through micro RNA analysis : applications to laboratory diagnostics
| Project/Area Number |
21590640
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Laboratory medicine
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| Research Institution | Tokai University |
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Principal Investigator |
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2009: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | 白血病 / 抗癌剤 / 耐性 / マイクロRNA / 抗がん剤 / FLT-3 / Ara-C / 抗癌剤耐 / FLT-3-I / 白血病細胞 / 抗癌剤耐性 / FLT3-ITD |
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| Research Abstract |
Expression of numerous genes is altered in drug-resistant tumor cells. MicroRNA is known as a regulating factor in the gene expression. The aim of this study was to clarify roles of micro RNA expression in drug-resistant leukemia cells, and its possible application in the diagnosis of resistance. When leukemia cells were transfected with FLT3-ITD, a major poor risk factor, specific resistance to ara-C was found. Altered pattern of micro RNA was demonstrated when analyzed by DNA microarray. This experimental system can be used as a model for diagnosis of drug resistance.
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Report
(4 results)
Research Products
(23 results)
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[Journal Article] Successful Treatment of Childhood Hypocellular Acute Myeloid Leukemia2012
Author(s)
Yamamoto M, Hori T, Hatakeyama N, Igarashi K, Iesato K, Nakanishi K, Noguchi H, Miyachi H, Ito M, Tsutsumi H, Suzuki N
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Journal Title
J Pediatr Hematol Oncol
Volume: (印刷中)
Related Report
Peer Reviewed
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[Journal Article] Clinical and pathological features of B-cell non-Hodgkin lymphomas lacking the surface expression of immunoglobulin light chain2012
Author(s)
Matsushita H, Nakamura N, Tanaka Y, Ohgiya D, Tanaka Y, Damdinsuren A, Asai S, Yabe M, Kawada H, Ogawa Y, Ando K, Miyachi H
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Journal Title
Clin Chem Lab Med
Volume: (印刷中)
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Peer Reviewed
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[Journal Article] The tortoiseshell pattern in one or both sides of the submandibular glands in mucosa-associated lymphoid tissue lymphoma is related to chromosomal aberrations and the disease extent2010
Author(s)
Asai S, Okami, K, Nakamura, N, Ogawa Y, Ohta Y, Ogase Y, Jin G, Matsushita, H, Miyachi H
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Journal Title
J Ultrasound Med
Volume: 29
Pages: 111-115
Related Report
Peer Reviewed
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[Presentation] CD34+/CD38+cells from human cord blood initiate APL by induction of PML-RARA2011
Author(s)
Matsushita H, Yahata T, Nakamura Y, Sheng Y, Muguruma Y, Matsuzawa H, Uno T, Takanashi T, Satou T, Tanaka M, Hayashi H, Miyachi H, Ando K
Organizer
The 73^<rd> annual meeting of the Japanese Society of Hematology
Place of Presentation
名古屋国際会議場(名古屋)
Year and Date
2011-10-16
Related Report
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