| Project/Area Number |
21590644
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Laboratory medicine
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| Research Institution | Kumamoto Health Science University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
MATSUSHIMA Kazumi 熊本保健科学大学, 医学検査学科, 講師 (00369125)
ANRAKU Kensaku 熊本保健科学大学, 医学検査学科, 講師 (80389543)
ANDO Yukio 熊本大学, 大学院・生命科学研究部・病態情報解析学分野, 教授 (20253742)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2011: ¥520,000 (Direct Cost: ¥400,000、Indirect Cost: ¥120,000)
Fiscal Year 2010: ¥520,000 (Direct Cost: ¥400,000、Indirect Cost: ¥120,000)
Fiscal Year 2009: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
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| Keywords | 脂質 / HDL / アポリポ蛋白E / アポE-rich HDL / コレステロール / アポ蛋白E / アポタンパクE |
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| Research Abstract |
Cholesteryl ester transfer protein(CETP) inhibitors increase the concentration of HDL having large particle size and an abundance of apolipoprotein(apo) E, which is known as"apoE-rich HDL". However, there have been no published studies to date on techniques for measuring apoE-rich HDL and anti-atherogenic functions such as the ability removing cholesterol. In this study, we demonstrated the anti-atherogenic action of apoE-rich HDL using serum samples from patients with CETP deficiency or cholestasis associated with elevated levels of this type of lipoprotein like CETP inhibitors. Furthermore, we developed a method for measuring total HDL cholesterol(HDL-C) including apoE-rich HDL using a nonionic surfactant, a polyalkylene glycol, with high specificity for this HDL.
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