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Environmental and genetic risk factors for gallbladder cancer in Bolivian people

Research Project

Project/Area Number 21590650
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Hygiene
Research InstitutionNiigata University of Health and Welfare

Principal Investigator

YAMAMOTO Masaharu  新潟医療福祉大学, 医療技術学部, 教授 (40018693)

Co-Investigator(Kenkyū-buntansha) ENDOH Kazuo  新潟医療福祉大学, 健康科学部, 教授 (60176790)
SAITO Toshi  新潟医療福祉大学, 健康科学部, 教授 (40339958)
TSUCHIYA Yasuo  新潟医療福祉大学, 医療技術学部, 教授 (60334679)
Project Period (FY) 2009 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2011: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2009: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords胆嚢がん / 症例-対照研究 / 環境要因 / 遺伝要因 / 国際情報交換 / ボリビア
Research Abstract

We measured the concentrations of aflatoxins in Bolivian red chili pepper, and then determined whether aflatoxin-contaminated red chili pepper consumption is the cause of the development of gallbladder cancer. Aflatoxin B1 was detected at concentration of 11.3 ppb from 1 sample. However the concentrations of several red chili peppers were less than the detection limit of our analysis method. Since our findings suggest that the low-level but protracted exposure to aflatoxins may be associated with the development of gallbladder cancer, further studies, such as investigation of the background of contaminants, are needed.

Report

(4 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • 2009 Annual Research Report
  • Research Products

    (3 results)

All 2011 2010 Other

All Journal Article (2 results) (of which Peer Reviewed: 2 results) Presentation (1 results)

  • [Journal Article] Mutagenicity and mutagens of the red chili pepper as gallbladder cancer risk factor in Chilean women2011

    • Author(s)
      Tsuchiya Y, Terao M, Okano K, Nakamura K, Oyama M, Ikegami K, Yamamoto M
    • Journal Title

      Asian Pac J Cancer Prev

      Volume: 12 Pages: 471-6

    • URL

      http://www.apocp.org/cancer_download/Volume12_No2/471-6_cYasuo_Tsuchiya.pdf

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Polimorfismo genetico relacionado al metabolismo de la aflatoxina y el riesgo de cancer vesicular en mujeres chilenas

    • Author(s)
      Tsuchiya Y, Baez S, Calvo A, Pruyas M, Nakamura K, Kiyohara C, Endoh K, Asai T, Yamamoto M
    • Journal Title

      Revista Gastroenterologia Latinoamericana

      Volume: (in press)

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Presentation] Aflatoxin contamination of red chili pepper as a risk factor for gallbladder cancer in Chilean women2010

    • Author(s)
      Tsuchiya Y, Serra I, Endoh K, Yamamoto M
    • Organizer
      XXXVII Chilean Congress of Gastroenterology
    • Place of Presentation
      Puerto Varas, Chile
    • Related Report
      2011 Final Research Report

URL: 

Published: 2009-04-01   Modified: 2018-02-02  

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