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Increased number of mesothelioma patients with low pulmonary asbestos and nonasbestos mineral fiber concentrations and its significance

Research Project

Project/Area Number 21590654
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Hygiene
Research InstitutionAichi University of Education

Principal Investigator

HISANAGA Naomi  愛知教育大学, 保健環境センター, 特別教授 (90111856)

Co-Investigator(Kenkyū-buntansha) SAKAKIBARA Yoko  愛知教育大学, 保健環境センター, 講師 (90242891)
Co-Investigator(Renkei-kenkyūsha) KAMIJIMA Michihiro  名古屋市立大学, 大学院・医学研究科, 教授 (80281070)
Project Period (FY) 2009 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2011: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2010: ¥520,000 (Direct Cost: ¥400,000、Indirect Cost: ¥120,000)
Fiscal Year 2009: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Keywords産業衛生 / 中皮腫 / 石綿 / 非石綿繊維 / 肺内濃度
Research Abstract

This study aimed to elucidate the reason why the number of mesothelioma patients with low pulmonary asbestos and nonasbestos mineral fiber concentrations had increased recently. The results of the study suggested that it was derived from not only the clearance of inhaled fibers but also the decrease of cumulative exposure amounts of fibers due to the improvement of working place environments and shortening of exposed years. It would be very important to pay attention to early detection of mesothelioma among workers exposed to relatively small amount of asbestos and to prevent further asbestos exposure in working places.

Report

(4 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • 2009 Annual Research Report
  • Research Products

    (34 results)

All 2011 2010 2009

All Journal Article (13 results) (of which Peer Reviewed: 9 results) Presentation (21 results)

  • [Journal Article] ひる石および吹付けひる石に含まれる石綿分析2011

    • Author(s)
      酒井潔、久永直見、榊原洋子
    • Journal Title

      名古屋市衛生研究所報

      Volume: 57号 Pages: 1-4

    • Related Report
      2011 Final Research Report
  • [Journal Article] ひる石吹付け材が使われた校舎における石綿曝露リスク管理方式に関する研究2011

    • Author(s)
      榊原洋子、酒井潔、久永直見
    • Journal Title

      環境と安全

      Volume: 2巻 Pages: 39-49

    • NAID

      130002146941

    • Related Report
      2011 Final Research Report 2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Pleuralplaque profiles on the chest radiographs and CT scans of asbestos-exposed Japanese construction workers2011

    • Author(s)
      Momen Elshazley, Eiji Shibata, Naomi Hisanaga, Gaku Ichihara, Ashraf A. Ewis, Michihiro Kamijima, Sahoko Ichihara, Kiyoshi Sakai, Mitsuo Sato, Masashi Kondo, Yoshinori Hasegawa
    • Journal Title

      Industrial Health

      Volume: Vol.49 Pages: 626-633

    • NAID

      130004828645

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Risk Assessment of Baby Powder Exposure through Inhalation2011

    • Author(s)
      Min Chaul Moon, Jung Duck Park, Byung Soon Choi, So Young Park, Dong Won Kim, Yong Hyun Chung, Naomi Hisanaga、Il Je Yu
    • Journal Title

      Toxicological Research

      Volume: Vol.27 Pages: 137-141

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Pleural plaque profiles on the chest radiographs and CT scans of asbestos-exposed Japanese construction workers2011

    • Author(s)
      Elshazley M, Hisanaga N, Ichihara G, Ichihara S, et al
    • Journal Title

      Industrial Health

      Volume: 49 Pages: 626-633

    • NAID

      130004828645

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Risk Assessment of Baby Powder Exposure through Inhalation2011

    • Author(s)
      Min Chaul Moon, Naomi Hisanaga, ほか
    • Journal Title

      Toxicological Research

      Volume: 27(未定)(受理済)

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 労働環境衛生対策の過去・現在・未来-石綿を例として-2010

    • Author(s)
      久永直見
    • Journal Title

      学術の動向

      Volume: 15巻 Pages: 24-27

    • NAID

      130000450701

    • Related Report
      2011 Final Research Report 2010 Annual Research Report
  • [Journal Article] 溶接工肺2009

    • Author(s)
      久永直見、榊原洋子、柴田英治
    • Journal Title

      日本胸部臨床

      Volume: 68巻増刊

    • Related Report
      2011 Final Research Report
  • [Journal Article] Transfer of occupational health problems from a developed to developing country : Lessons from the Japan-South Korea experience2009

    • Author(s)
      Park JS, Hisanaga N, Kim YH
    • Journal Title

      Am J Ind Med

      Volume: 52 Pages: 625-632

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Comparison of lung asbestos fiber content in cancer subjects with healthy individuals with no known history of occupational asbestos exposure in Korea2009

    • Author(s)
      Han JH, Park JD, Sakai K, Hisanaga N, Il Je Yu
    • Journal Title

      J Toxicol Environ Health, Part A

      Volume: 72 Pages: 1292-1295

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Comparison of lung asbestos fiber content in cancer subjects with healthy individuals with no known history of occupational asbestos exposure in Korea2009

    • Author(s)
      Han JH, Park JD, Sakai K, Hisanaga N, ほか
    • Journal Title

      J Toxicol Environ Health, Part A 72

      Pages: 1292-1295

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Transfer of occupational health problems from a developed to a developing country : Lessons from the Japan-South Korea experience2009

    • Author(s)
      Park JS, Hisanaga N, Kim YH
    • Journal Title

      Am J Ind Med 52

      Pages: 625-632

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 溶接工肺2009

    • Author(s)
      久永直見, 榊原洋子, 柴田英治
    • Journal Title

      日本胸部臨床 68増刊

    • Related Report
      2009 Annual Research Report
  • [Presentation] Are nonasbestos nanofibers detected in human lung tissue in Japan mesotheliomagenic2011

    • Author(s)
      Naomi Hisanaga, ほか
    • Organizer
      ナノバイオメデイシンシンポジイム
    • Place of Presentation
      名古屋
    • Year and Date
      2011-02-21
    • Related Report
      2010 Annual Research Report
  • [Presentation] 含鉄小体濃度と石綿・非石綿繊維の長さ・濃度との関係2011

    • Author(s)
      鈴木隆佳、榊原洋子、久永直見
    • Organizer
      2011年度日本産業衛生学会東海地方会学会
    • Place of Presentation
      名古屋
    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Presentation] 建設業従事肺がん患者における胸膜肥厚斑の有無と肺内石綿・非石綿繊維濃度2011

    • Author(s)
      酒井潔、久永直見
    • Organizer
      2011年度日本産業衛生学会東海地方会学会
    • Place of Presentation
      名古屋
    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Presentation] ヒト肺組織における酸化・ニトロ化DNA損傷と石綿曝露との関連2011

    • Author(s)
      平工雄介、酒井潔、柴田英治、上島通浩、久永直見、村田真理子
    • Organizer
      2011年度日本産業衛生学会
    • Place of Presentation
      東京
    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Presentation] 肺内含鉄小体濃度と石綿・非石綿繊維濃度との関連に関する検討-第1報-2011

    • Author(s)
      鈴木隆佳、榊原洋子、酒井潔、柴田英治、久永直見、岸孝彦、後藤峰弘、小林章雄
    • Organizer
      2011年度日本産業衛生学会
    • Place of Presentation
      東京
    • Related Report
      2011 Final Research Report
  • [Presentation] 肺内石綿分析からクリソタイル起因と推測された中皮腫症例2011

    • Author(s)
      酒井潔、久永直見、柴田英治、上島通浩、市原学、那須民江
    • Organizer
      2011年度日本産業衛生学会
    • Place of Presentation
      東京
    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Presentation] 石綿肺がん労災認定基準を満たす建築業従事者36例の石綿曝露歴2011

    • Author(s)
      久永直見、柴田英治、酒井潔、上島通浩、久保田均、毛利一平
    • Organizer
      2011年度日本産業衛生学会
    • Place of Presentation
      東京
    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Presentation] Are nonasbestos nanofibers detected in human lung tissue in Japan mesotheliomagenic2011

    • Author(s)
      Naomi Hisanaga, Kiyoshi Sakai, Eiji Shibata, Michihiro Kamijima, Hisao Naito, Gaku Ichihara
    • Organizer
      Nano-biomedicine Symposium
    • Place of Presentation
      Nagoya
    • Related Report
      2011 Final Research Report
  • [Presentation] Nonasbestos fibers in the lung tissue of patients with mesothelioma give a hint for mesotheliomagenicity of nanofibers2010

    • Author(s)
      Naomi Hisanaga, ほか
    • Organizer
      The 10^<th> International Conference of the international mesothelioma interest group
    • Place of Presentation
      京都
    • Year and Date
      2010-09-02
    • Related Report
      2010 Annual Research Report
  • [Presentation] Trends in asbestos and nonasbestos fiber concentrations in the lung tissues of Japanese patients with mesothelioma2010

    • Author(s)
      Kiyoshi Sakai, Naomi Hisanaga, ほか
    • Organizer
      The 10^<th> International Conference of the international mesothelioma interest group
    • Place of Presentation
      京都
    • Year and Date
      2010-09-02
    • Related Report
      2010 Annual Research Report
  • [Presentation] Formation of 8-nitroguanine, a DNA lesion in the lung of asbestos-exposed mice in relation to inflammation-related carcinogenesis2010

    • Author(s)
      Yusuke Hiraku, Naomi Hisanaga, ほか
    • Organizer
      The 10^<th> International Conference of the international mesothelioma interest group
    • Place of Presentation
      京都
    • Year and Date
      2010-09-02
    • Related Report
      2010 Annual Research Report
  • [Presentation] Formation of 8-nitroguanine, a DNA lesion in the lung of asbestos-exposed mice in relation to inflammation-related carcinogenesis2010

    • Author(s)
      Yusuke Hiraku, Kiyoshi Sakai, Eiji Shibata, Naomi Hisanaga, Mariko Murata
    • Organizer
      The 10^<th> International Conference of the International Mesothelioma Interest Group
    • Place of Presentation
      Kyoto
    • Related Report
      2011 Final Research Report
  • [Presentation] Trends in asbestos and nonasbestos fiber concentrations in the lung tissues of Japanese patients with mesothelioma2010

    • Author(s)
      Kiyoshi Sakai, Naomi Hisanaga, Eiji Shibata, Michihiro Kamijima, Gaku Ichihara, Yasuhiro Takeuchi, Tamie Nakajima
    • Organizer
      The 10^<th> International Conference of the International Mesothelioma Interest Group
    • Place of Presentation
      Kyoto
    • Related Report
      2011 Final Research Report
  • [Presentation] Nonasbestos fibers in the lung tissue of patients with mesothelioma give a hint formesotheliomagenicity of nanofibers2010

    • Author(s)
      Naomi Hisanaga, Kiyoshi Sakai, Eiji Shibata, Yoko Sakakibara, Michihiro Kamijima, Gaku Ichihara
    • Organizer
      The 10^<th> International Conference of the International Mesothelioma Interest Group
    • Place of Presentation
      Kyoto
    • Related Report
      2011 Final Research Report
  • [Presentation] 蛇紋岩分布地で働く人および蛇紋岩使用者の石綿曝露2010

    • Author(s)
      久永直見、酒井潔、榊原洋子、柴田英治
    • Organizer
      2010年度日本産業衛生学会東海地方会学会
    • Place of Presentation
      浜松
    • Related Report
      2011 Final Research Report
  • [Presentation] ひる石ならびに吹付けひる石中の石綿2010

    • Author(s)
      酒井潔、榊原洋子、久永直見
    • Organizer
      2010年度日本産業衛生学会東海地方会学会
    • Place of Presentation
      浜松
    • Related Report
      2011 Final Research Report
  • [Presentation] 肺がん患者における職業的石綿曝露と肺内石綿濃度2010

    • Author(s)
      酒井潔、久永直見、柴田英治、上島通浩、市原学、那須民江
    • Organizer
      2010年度日本産業衛生学会
    • Place of Presentation
      福井
    • Related Report
      2011 Final Research Report
  • [Presentation] Coping with asbestos incidence in Japan2009

    • Author(s)
      Hisanaga N
    • Organizer
      韓国毒性学会2009年度春季毒性学専門教育・ワークショップ
    • Place of Presentation
      ソウル大学 (ソウル)
    • Year and Date
      2009-05-20
    • Related Report
      2009 Annual Research Report
  • [Presentation] 学生アルバイト起因が疑われた胸膜肥厚斑および中皮腫2009

    • Author(s)
      久永直見、榊原洋子、酒井潔、柴田英治
    • Organizer
      2009年度日本産業衛生学会東海地方会学会
    • Place of Presentation
      名古屋
    • Related Report
      2011 Final Research Report
  • [Presentation] ヒト肺内のナノレベル直径の無機繊維とその健康影響2009

    • Author(s)
      酒井潔、久永直見、柴田英治、上島通浩、市原学、那須民江
    • Organizer
      2009年度日本産業衛生学会
    • Place of Presentation
      福岡
    • Related Report
      2011 Final Research Report
  • [Presentation] Coping with asbestos incident in Japan2009

    • Author(s)
      Hisanaga N
    • Organizer
      韓国毒性学会2009年度春季毒性学専門教育・ワークショップ
    • Place of Presentation
      Seoul
    • Related Report
      2011 Final Research Report

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Published: 2009-04-01   Modified: 2016-04-21  

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