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Genetic epidemiological study on metabolic syndrome and its application to personalized health promotion

Research Project

Project/Area Number 21590658
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Hygiene
Research InstitutionWakayama Medical University

Principal Investigator

TAKESHITA Tatsuya  和歌山県立医科大学, 医学部, 教授 (20150310)

Co-Investigator(Kenkyū-buntansha) MURE Kanae  和歌山県立医科大学, 医学部, 講師 (90268491)
Project Period (FY) 2009 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2009: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywords肥満 / メタボリックシンドローム / アディポネクチン / コーヒー / 内臓脂肪 / 生活習慣 / 遺伝子多型 / アルデヒド脱水素酵素 / アルコール / 遺伝疫学 / 予防
Research Abstract

The association of coffee consumption and MetS-related biomarkers including visceral and subcutaneous fat area(VFA and SFA), total, low-, medium-and high-molecularweight serum adiponectin(T-, LMW-, MMW-and HMW-Ad)levels were analyzed among a total of 364 Japanese male workers(36-61 y old)adjusting for age, alcohol drinking, smoking, walking status and BMI. Both light(1-3 cups/day)and moderate (〓4cups/day)coffee consumption showed significant inverse associations with VFA and VFAISFA ratio(P<0.0001). Moderate coffee consumption showed a favorable tendency toward these associations with T-Ad(P=0.06)and HMW-Ad(P=0.07)levels.
The relationship between coffee consumption and the prevalence of metabolic syndrome was investigated in Japanese civil servants. The study participants were 3284 employees(2335 men and 948 women)aged 20 to 65 years. Metabolic syndrome was diagnosed in 3740f the 2335 men(16.0%)and 320f the 948 women(3.4%). In multiple logistic regression analyses, the odds ratios(ORs)among men fbr the presence of metabolic syndrome were 0.61(0.39-0.95), among moderate(〓4 cups of coffee per day)coffee drinkers as compared with non-coffee drinkers. Among all components of metabolic syndrome, high blood pressure and high triglyceride level were inversely associated with moderate coffee consumption in men, after adjusting for age, body mass index, smoking status, drinking status, and exercise. However, in women, moderate coffee consumption was not significantly associated with the prevalence of metabolic syndrome or its components.

Report

(4 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • 2009 Annual Research Report
  • Research Products

    (33 results)

All 2012 2011 2010 2009 Other

All Journal Article (23 results) (of which Peer Reviewed: 20 results) Presentation (9 results) Book (1 results)

  • [Journal Article] Relationship Between Coffee Consumption and Prevalence of Metabolic Syndrome Among Japanese Civil Servants2012

    • Author(s)
      Matsuura H, Mure K, Nishio N, Kitano N, Nagai N and Takeshita T
    • Journal Title

      Journal of Epidemiology

      Volume: 22 Issue: 2 Pages: 160-166

    • DOI

      10.2188/jea.JE20110068

    • NAID

      10030213606

    • ISSN
      0917-5040, 1349-9092
    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Development of gastric cancer in nonatrophic stomach with highly active inflammation identified by serum levels of pepsinogen and Helicobacter pylori antibody together with endoscopic rugal hyperplastic gastritis2012

    • Author(s)
      Watanabe M, Kato J, Inoue I, Yoshimura N, Yoshida T, Mukoubayashi C, Deguchi H, Enomoto S, Ueda K, Maekita T, Iguchi M, Tamai H, Utsunomiya H, Yamamichi N, Fujishiro M, Iwane M, Tekeshita T, Mohara O, Ushijima T, Ichinose M
    • Journal Title

      Int J Cancer

      Volume: 131巻 Issue: 11 Pages: 2632-2642

    • DOI

      10.1002/ijc.27514

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Skin sensitization study by a new qualitative structure-toxicity relationships (QSTR) approach : K-step Yard sampling (KY) methods2012

    • Author(s)
      Sato K, Umemura T, Tamura T, Kusaka Y, Aoyama K, Ueda A, Harada K, Minamoto K, Otsuki T, Yamashita K, Haitsuka M, Takeshita T, Shibata E, Dobashi K, Kameo S, Miyagawa M, Kaniwa M, Yoshida T, Fukushima T, Yuta K
    • Journal Title

      J Oral Tissue Engin

      Volume: 9巻 Pages: 167-173

    • NAID

      130004941182

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] アルコールと生活習慣病予防. 分子疫学研究の成果とその応用2012

    • Author(s)
      竹下達也
    • Journal Title

      公衆衛生

      Volume: 76巻 Pages: 205-209

    • Related Report
      2011 Final Research Report
  • [Journal Article] Autopsy Cases of Lung Cancer and Liver Cancer among Japanese Dentists-A Review of the Annual of the Pathological Autopsy Cases in Japan-2011

    • Author(s)
      Nishio N, Tanaka H, Nishio J, Kouda K, Takeshita T
    • Journal Title

      Ind Health

      Volume: 49巻 Pages: 663-671

    • NAID

      130004828650

    • URL

      http://dx.doi.org/10.2486/indhealth.MS943

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Elevated risk of colorectal adenoma with Helicobacter pylori-related chronic gastritis2011

    • Author(s)
      Inoue I, Mukoubayashi C, Yoshimura N, Niwa T, Deguchi H, Watanabe M, Enomoto S, Maekita T, Ueda K, Iguchi M, Yanaoka K, Tamai H, Arii K, Oka M, Fujishiro M, Takeshita T, Iwane M, Mohara O, Ichinose M
    • Journal Title

      a population-based case-control study

      Volume: 129巻 Issue: 11 Pages: 2704-2711

    • DOI

      10.1002/ijc.25931

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Does the Japanese Society for Hygiene need its own Code of Conduct?-A comparison of questionnaire between councilors and junior members-2011

    • Author(s)
      Ikeda W, Inaba Y, Takeshita T, Yoshida K,Ogoshi K, Okamoto K
    • Journal Title

      Environ Health Prev Med

      Volume: 16巻 Issue: 3 Pages: 178-184

    • DOI

      10.1007/s12199-010-0175-9

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Autopsy Cases of Lung Cancer and Liver Cancer among Japanese Dentists-A Review of the Annual of the Pathological Autopsy Cases in Japan-2011

    • Author(s)
      Nishio N
    • Journal Title

      Ind Health

      Volume: 49 Pages: 663-671

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Association of monocyte subset counts with coronary fibrous cap thickness in patients with unstable angina pectoris2010

    • Author(s)
      Imanishi T, Ikejima H, Tsujioka H, Kuroi A, Ishibashi K, Komukai K, Tanimoto T, Ino Y, Takeshita T, Akasaka T
    • Journal Title

      Atherosclerosis

      Volume: 212巻 Pages: 628-635

    • URL

      http://dx.doi.org/10.1016/j.atherosclerosis.2010.06.025

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] A respiratory sensitization study by a new quantitative structure-activity relationships (QSAR)2010

    • Author(s)
      Sato K, Umemura T, Tamura T, Kusaka Y, Ido T, Aoyama K, Ueda A, Harada K, Minamoto K, Otsuki T, Yamashita K, Takeshita T, Shibata E, Dobashi K, Kameo S, Miyagawa M, Kaniwa M, Yoshida T, Fukushima T, Yuta K
    • Journal Title

      AATEX

      Volume: 15巻 Pages: 124-130

    • NAID

      10029747707

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] First evaluation of real-time nitric oxide changes in the coronary circulation in patients with non-ischaemic dilated cardiomyopathy using a catheter-type sensor2010

    • Author(s)
      Takarada S, Imanishi T, Goto M, Mochizuki S, Ikejima H, Tsujioka H, Kuroi A, Takeshita T, Akasaka T
    • Journal Title

      Eur Heart J

      Volume: 31巻 Issue: 23 Pages: 2862-2870

    • DOI

      10.1093/eurheartj/ehq156

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Upregulation of fractalkine and its receptor, CX3CR1, is associated with coronary plaque rupture in patients with unstable angina pectoris2010

    • Author(s)
      Ikejima H, Imanishi T, Tsujioka H, Kashiwagi M, Kuroi A, Tanimoto T, Kitabata H, Ishibashi K, Komukai K, Takeshita T, Akasaka T
    • Journal Title

      Circ J

      Volume: 74巻 Pages: 337-345

    • NAID

      10025942643

    • URL

      http://dx.doi.org/10.1253/circj.CJ-09-0484

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Preventive effects of etodolac, a selective cyclooxygenase-2 inhibitor, on cancer development in extensive metaplastic gastritis, a Helicobacter pylori-negative precancerous lesion2010

    • Author(s)
      Yanaoka K, Oka M, Yoshimura N, Deguchi H, Mukoubayashi C, Enomoto S, Maekita T, Inoue I, Ueda K, Utsunomiya H, Iguchi M, Tamai H, Fujishiro M, Nakamura Y, Tsukamoto T, Inada K, Takeshita T, Ichinose M
    • Journal Title

      Int J Cancer

      Volume: 126巻 Issue: 6 Pages: 1467-1473

    • DOI

      10.1002/ijc.24862

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Association of ALDH2 Genotypes with Periodontitis Progression2010

    • Author(s)
      Nishida N , Tanaka M, Sekine S, Takeshita T, Nakayama K, Morimoto K, Shizukuishi S
    • Journal Title

      J Dental Res

      Volume: 89巻 Issue: 2 Pages: 138-142

    • DOI

      10.1177/0022034509356045

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] 植物由来物質による紫外線誘発細胞障害抑制効果について2010

    • Author(s)
      牟礼佳苗,竹下達也
    • Journal Title

      EICA

      Volume: 15巻 Pages: 9-12

    • NAID

      10026688360

    • Related Report
      2011 Final Research Report
  • [Journal Article] ライフスタイル医学と分子遺伝疫学2010

    • Author(s)
      竹下達也
    • Journal Title

      公衆衛生

      Volume: 74巻 Pages: 772-775

    • Related Report
      2011 Final Research Report
  • [Journal Article] Association of ALDH2 Genotypes with Periodontitis Progression.2010

    • Author(s)
      Nishida N
    • Journal Title

      J Dental Res

      Volume: 89 Pages: 138-142

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Preventive effects of etodolac, a selective cyclooxygenase-2 inhibitor, on cancer development in extensive metaplastic gastritis, a Helicobacter pylori-negative precancerous lesion.2010

    • Author(s)
      Yanaoka K
    • Journal Title

      Int J Cancer

      Volume: 126 Pages: 1467-1473

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Upregulation of fractalkine and its receptor, CX3CR1, is associated with coronary plaque rupture in patients with unstable angina pectoris2010

    • Author(s)
      Ikejima H
    • Journal Title

      Circ J

      Volume: 74 Pages: 337-345

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Smoking prevalence among dentists in Hyogo, Japan 20032009

    • Author(s)
      Nishio N
    • Journal Title

      Ind Health 47

      Pages: 431-435

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Eradication of Helicobacter pylori prevents cancer development in subjects with mild gastric atrophy identified by serum pepsinogen levels2009

    • Author(s)
      Yanaoka K
    • Journal Title

      Int J Cancer 125

      Pages: 2697-2703

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Preventive effects of etodolac, a selective cyclooxygenase-2 inhibitor, on cancer development. in extensive metaplastic gastritis, a Helicobacter pylori-negative precancerous lesion2009

    • Author(s)
      Yanaoka K
    • Journal Title

      Int J Cancer 126

      Pages: 1467-1473

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Inverse association of habitual coffee consumption with metabolic syndrome-related biomarkers involving adiponectin

    • Author(s)
      Mure K, Maeda S, Mukoubayashi C, Mugitani K, Iwane M, Kinoshita F, Mohara O, Takeshita T
    • Journal Title

      Nutrition

      Volume: (in press)

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Presentation] 職域男性におけるコーヒー摂取量および飲酒量と血清総アディポネクチン値との関連性2011

    • Author(s)
      前田真也,牟礼佳苗,竹下達也,麦谷耕一,岩根幹能,木下藤寿,茂原治
    • Organizer
      第84回日本産業衛生学会
    • Place of Presentation
      東京
    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Presentation] コーヒー摂取等の生活習慣とメタボリックシンドロームとの関連性について2011

    • Author(s)
      牟礼佳苗,竹下達也, 前田真也,麦谷耕一,岩根幹能,木下藤寿,茂原 治
    • Organizer
      第81回日本衛生学会総会
    • Place of Presentation
      誌上発表
    • Related Report
      2011 Final Research Report
  • [Presentation] 肥満関連遺伝子多型とメタボリックシンドロームの関連性2011

    • Author(s)
      牟礼佳苗,竹下達也,前田真也,麦谷耕一,岩根幹能,木下藤寿,茂原 治
    • Organizer
      第10回分子予防環境医学研究会大会
    • Place of Presentation
      京都市
    • Related Report
      2011 Final Research Report
  • [Presentation] コーヒー摂取とメタボリックシンドロームの関連性について2010

    • Author(s)
      牟礼佳苗
    • Organizer
      第80回日本衛生学会総会
    • Place of Presentation
      仙台国際センター(仙台市)
    • Year and Date
      2010-05-10
    • Related Report
      2010 Annual Research Report
  • [Presentation] 植物由来物質による紫外線誘発細胞障害抑制効果について2010

    • Author(s)
      牟礼佳苗,竹下達也
    • Organizer
      環境システム計測制御学会第22回EICA研究発表会
    • Place of Presentation
      滋賀県草津市
    • Related Report
      2011 Final Research Report
  • [Presentation] 職域男性における飲酒量と血清総アディポネクチン値との関連性の解析2010

    • Author(s)
      前田真也,牟礼佳苗,竹下達也,渡辺実香,向林知津,麦谷耕一,渡辺豊,岩根幹能,木下藤寿,湯川修也,茂原治
    • Organizer
      第83回日本産業衛生学会
    • Place of Presentation
      福井市
    • Related Report
      2011 Final Research Report
  • [Presentation] コーヒー摂取とメタボリックシンドロームの関連性について2010

    • Author(s)
      牟礼佳苗,前田真也,麦谷耕一,岩根幹能,木下藤寿,茂原 治,竹下達也
    • Organizer
      第80回日本衛生学会総会
    • Place of Presentation
      仙台市
    • Related Report
      2011 Final Research Report
  • [Presentation] 職域男性におけるβ3アドレナリン受容体遺伝子多型別の内臓脂肪面積、運動習慣と肝機能検査値との関連性についての解析2009

    • Author(s)
      前田真也
    • Organizer
      第82回日本産業衛生学会
    • Place of Presentation
      福岡国際会議場(福岡市)
    • Year and Date
      2009-05-21
    • Related Report
      2009 Annual Research Report
  • [Presentation] 職域男性におけるβ3アドレナリン受容体遺伝子多型別の内臓脂肪面積、運動習慣と肝機能検査値との関連性についての解析2009

    • Author(s)
      前田真也,牟礼佳苗,竹下達也,麦谷耕一,岩根幹能,木下藤寿,茂原 治
    • Organizer
      第82回日本産業衛生学会
    • Place of Presentation
      福岡市
    • Related Report
      2011 Final Research Report
  • [Book] 分子予防環境医学(分子予防環境医学研究会編)(飲酒)2010

    • Author(s)
      竹下達也
    • Publisher
      本の泉社
    • Related Report
      2010 Annual Research Report

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Published: 2009-04-01   Modified: 2016-04-21  

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