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Effect of exposure to xerophilic fungi on the onset and aggravation of mite-induced atopic dermatitis in NC/Nga mice.

Research Project

Project/Area Number 21590659
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Hygiene
Research InstitutionOita University of Nursing and Health Sciences

Principal Investigator

SADAKANE Kaori  大分県立看護科学大学, 看護学部, 助教 (20322381)

Project Period (FY) 2009 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2010: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2009: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Keywords予防医学 / 室内浮遊真菌 / アスペルギルス / アトピー性皮膚炎 / 増悪作用 / 好乾性真菌 / NC/Ngaマウス / 長期吸入曝露 / NC / Ngaマウス
Research Abstract

We investigated whether xerophilic fungi, Aspergillus aggravates mite-induced atopic dermatitis-like skin lesion in NC/Nga mice. Aspergillus is a kind of mold and found in a bedroom or living room. The topical application of the extract of Aspregillus on the lesion sites in mice was lightly affected on mite-induced atopic dermatitis. But the multiple subcutaneous injection of the extract led to increased allergic responses in subcutaneous inflammation sites. In addition, intratracheal injection of the extract for six months aggravated the atopic dermatitis in mice. Therefore, it is suggested that Aspergillus can be an aggravating factor for atopic dermatitis.

Report

(4 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • 2009 Annual Research Report
  • Research Products

    (10 results)

All 2011 Other

All Presentation (2 results) Remarks (8 results)

  • [Presentation] 好乾性真菌アスペルギルス抽出物をアトピー性皮膚炎発症部位に塗布したときの影響2011

    • Author(s)
      定金香里、市瀬孝道、高野裕久, 他
    • Organizer
      第52回大気環境学会年会
    • Place of Presentation
      長崎
    • Year and Date
      2011-09-15
    • Related Report
      2011 Final Research Report
  • [Presentation] アスペルギルス反復投与がダニ抗原誘発性アトピー性皮膚炎マウスモデルに及ぼす影響2011

    • Author(s)
      定金香里、市瀬孝道、高野裕久, 他
    • Organizer
      第81回日本衛生学会学術総会
    • Place of Presentation
      東京
    • Year and Date
      2011-03-26
    • Related Report
      2011 Final Research Report
  • [Remarks]

    • URL

      http://www.oita-nhs.ac.jp/univ_est/cat-top/cat106/

    • Related Report
      2011 Annual Research Report
  • [Remarks]

    • URL

      http://www.oita-nhs.ac.jp/research/dhs/patho/homepage.html

    • Related Report
      2011 Annual Research Report
  • [Remarks]

    • URL

      http://www.oita-nhs.ac.jp/member/cat5-top/

    • Related Report
      2011 Annual Research Report
  • [Remarks]

    • URL

      http://www.oita-nhs.ac.jp/univ_est/cat-top/cat106/

    • Related Report
      2010 Annual Research Report
  • [Remarks]

    • URL

      http://www.oita-nhs.ac.jp/research/dhs/patho/homepage.html

    • Related Report
      2010 Annual Research Report
  • [Remarks]

    • URL

      http://www.oita-nhs.ac.jp/member/cat5-top/

    • Related Report
      2010 Annual Research Report
  • [Remarks]

    • URL

      http://www.oita-nhs.ac.jp/research/nenpo/nenpo2006.pdf

    • Related Report
      2009 Annual Research Report
  • [Remarks]

    • URL

      http://www.oita-nhs.ac.jp/research/dhs/patho/research.html

    • Related Report
      2009 Annual Research Report

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Published: 2009-04-01   Modified: 2016-04-21  

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