Effect of exposure to xerophilic fungi on the onset and aggravation of mite-induced atopic dermatitis in NC/Nga mice.
| Project/Area Number |
21590659
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Hygiene
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| Research Institution | Oita University of Nursing and Health Sciences |
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Principal Investigator |
SADAKANE Kaori 大分県立看護科学大学, 看護学部, 助教 (20322381)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2010: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2009: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
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| Keywords | 予防医学 / 室内浮遊真菌 / アスペルギルス / アトピー性皮膚炎 / 増悪作用 / 好乾性真菌 / NC/Ngaマウス / 長期吸入曝露 / NC / Ngaマウス |
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| Research Abstract |
We investigated whether xerophilic fungi, Aspergillus aggravates mite-induced atopic dermatitis-like skin lesion in NC/Nga mice. Aspergillus is a kind of mold and found in a bedroom or living room. The topical application of the extract of Aspregillus on the lesion sites in mice was lightly affected on mite-induced atopic dermatitis. But the multiple subcutaneous injection of the extract led to increased allergic responses in subcutaneous inflammation sites. In addition, intratracheal injection of the extract for six months aggravated the atopic dermatitis in mice. Therefore, it is suggested that Aspergillus can be an aggravating factor for atopic dermatitis.
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Report
(4 results)
Research Products
(10 results)
