| Project/Area Number |
21590668
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Hygiene
|
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| Research Institution | Nippon Medical School |
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Principal Investigator |
LI Yingji 日本医科大学, 医学部, 講師 (60350039)
|
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| Co-Investigator(Kenkyū-buntansha) |
KAWADA Tomoyuki 日本医科大学, 大学院・医学研究科, 教授 (00224791)
AZUMA Arata 日本医科大学, 医学部, 教授 (10184194)
INAGAKI Hirofumi 日本医科大学, 医学部, 講師 (50213111)
HIRATA Yukiyo 日本医科大学, 医学部, 助教 (40322515)
|
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| Research Collaborator |
SAOTOME Takako 日本医科大学, 上級研究技術員
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| Project Period (FY) |
2009 – 2011
|
| Project Status |
Completed (Fiscal Year 2011)
|
| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2011: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
|
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| Keywords | 肺線維症 / ディーゼル排気粒子(DEP) / ブレオマイシン(BLM) / Nrf2 |
|---|
| Research Abstract |
Our results suggest that oxidative stress caused by diesel exhaust particles(DEPs) might be an important risk factor on the bleomycin(BLM) induced lung fibrosis, and the preventive effect by antioxidant is expected.
|
