A prospective cohort study on gene-environment interactions affecting atopic eczema

• Project/Area Number: 21590673
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Hygiene
• Research Institution: Fukuoka University
• Principal Investigator: MIYAKE Yoshihiro 福岡大学, 医学部, 准教授 (50330246)
• Co-Investigator(Kenkyū-buntansha): TANAKA Keiko 福岡大学, 医学部, 講師 (40341432) ; KIYOHARA Chikako 九州大学, 大学院・医学研究院, 講師 (00169963) ; SASAKI Satoshi 東京大学, 大学院・医学系研究科, 教授 (70275121)
• Project Period (FY): 2009 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000); Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2009: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
• Keywords: 分子遺伝疫学 / 社会医学 / 前向きコホート研究 / アレルギー・ぜんそく / 交互作用 / アトピー性皮膚炎 / リスク要因 / 遺伝子多型

Research Abstract

We investigated risk and preventive factors for allergic disorders using data from Kyushu Okinawa Maternal and Child Health Study. Especially, we assessed the gene-environment interactions. Nine original articles were accepted by several international academic journals.

Research Products

• [Journal Article] Dairy food, calcium, and vitamin D intake and prevalence of allergic disorders in pregnant Japanese women (2012)
  • Author(s): Miyake Y, Tanaka K, Okubo H, Sasaki S, Arakawa M.
  • Journal Title: Int J Tuberc Lung Dis Volume: 16 Pages: 255-261
  • Peer Reviewed
• [Journal Article] Smoking and prevalence of allergic disorders in Japanese pregnant women : baseline data from the Kyushu Okinawa Maternal and Child Health Study (2012)
  • Author(s): Tanaka K, Miyake Y, Arakawa M.
  • Journal Title: Environ Health Pages: 11-15
  • NAID: 120006979252
  • Peer Reviewed
• [Journal Article] Dietary meat and fat intake and prevalence of rhinoconjunctivitis in pregnant Japanese women : baseline data from the Kyushu Okinawa Maternal and Child Health Study (2012)
  • Author(s): Miyake Y, Tanaka K, Okubo H, Sasaki S, Arakawa M.
  • Journal Title: Nutr J Pages: 11-19
  • NAID: 120006979246
  • Peer Reviewed
• [Journal Article] ADAM33 genetic polymorphisms, smoking, and rhinoconjunctivitis in Japanese women : the Kyushu Okinawa Maternal and Child Health Study (2012)
  • Author(s): Miyake Y, Tanaka K, Arakawa M.
  • Journal Title: Hum Immunol Volume: 73 Pages: 411-415
  • Peer Reviewed
• [Journal Article] Smoking and prevalence of allergic disorders in Japanese pregnant women : baseline data from the Kyushu Okinawa Maternal and Child Health Study (2012)
  • Author(s): Tanaka K, Miyake Y, Arakawa M
  • Journal Title: Environ Health Volume: 11 Issue: 1 Pages: 15-15
  • DOI: 10.1186/1476-069x-11-15
  • NAID: 120006979252
  • Peer Reviewed
• [Journal Article] ADAM33 polymorphisms, smoking, and asthma in Japanese women : Kyushu Okinawa Maternal and Child Health Study (2012)
  • Author(s): Miyake Y, Tanaka K, Arakawa M
  • Journal Title: Int J Tuberc Lung Dis Volume: (印刷中)
  • Peer Reviewed
• [Journal Article] Dietary meat and fat intake and prevalence of rhinoconjunctivitis in pregnant Japanese women : baseline data from the Kyushu Okinawa Maternal and Child Health Study (2012)
  • Author(s): Miyake Y, Tanaka K, et al
  • Journal Title: Nutr J Volume: 11 Issue: 1 Pages: 19-19
  • DOI: 10.1186/1475-2891-11-19
  • NAID: 120006979246
  • Peer Reviewed
• [Journal Article] Sibling number and prevalence of allergic disorders in pregnant Japanese women : baseline data from the Kyushu Okinawa Maternal and Child Health Study (2011)
  • Author(s): Miyake Y, Tanaka K, Arakawa M.
  • Journal Title: BMC Public Health Pages: 11-561
  • NAID: 120006980638
  • Peer Reviewed
• [Journal Article] IL13 genetic polymorphisms, smoking, and eczema in women : a case-control study in Japan (2011)
  • Author(s): Miyake Y, Tanaka K, Arakawa M.
  • Journal Title: BMC Med Genet Pages: 12-142
  • NAID: 120006980634
  • Peer Reviewed
• [Journal Article] Case-control study of IL13 polymorphisms, smoking, and rhinoconjunctivitis in Japanese women : the Kyushu Okinawa Maternal and Child Health Study (2011)
  • Author(s): Miyake Y, Tanaka K, Arakawa M.
  • Journal Title: BMC Med Genet Pages: 12-143
  • Peer Reviewed
• [Journal Article] Organochlorine concentrations in breast milk and prevalence of allergic disorders in Japanese women (2011)
  • Author(s): Miyake Y, Tanaka K, Masuzaki Y, Sato N, Ikeda Y, Chisaki Y, Arakawa M.
  • Journal Title: Chemosphere Volume: 85 Pages: 374-378
  • Peer Reviewed
• [Journal Article] Sibling number and prevalence of allergic disorders in pregnant Japanese women : baseline data from the Kyushu Okinawa Maternal and Child Health Study (2011)
  • Author(s): Miyake Y, Tanaka K, Arakawa M
  • Journal Title: BMC Public Health Volume: 11 Issue: 1 Pages: 561-561
  • DOI: 10.1186/1471-2458-11-561
  • NAID: 120006980638
  • Peer Reviewed
• [Journal Article] IL13 genetic polymorphisms, smoking, and eczema in women : a case-control study in Japan (2011)
  • Author(s): Miyake Y, Tanaka K, Arakawa M
  • Journal Title: BMC Med Genet Volume: 12 Issue: 1 Pages: 142-142
  • DOI: 10.1186/1471-2350-12-142
  • NAID: 120006980634
  • Peer Reviewed
• [Journal Article] Case-control study of IL13 polymorphisms, smoking, and rhinoconjunctivitis in Japanese women : the Kyushu Okinawa Maternal and Child Health Study (2011)
  • Author(s): Miyake Y, Tanaka K, Arakawa M
  • Journal Title: BMC Med Genet Volume: 12 Issue: 1 Pages: 143-143
  • DOI: 10.1186/1471-2350-12-143
  • Peer Reviewed
• [Journal Article] Case-control study of eczema associated with IL13 genetic polymorphisms in Japanese children. (2011)
  • Author(s): Miyake Y, et al.
  • Journal Title: Int Arch Allergy Immunol Volume: 154 Pages: 328-335
  • Peer Reviewed
• [Journal Article] Dietary intake of antioxidant vitamins and risk of Parkinson's disease : a case-controlstudy in Japan. (2011)
  • Author(s): Miyake Y, et al.
  • Journal Title: Eur J Neurol Volume: 18 Pages: 106-113
  • Peer Reviewed
• [Journal Article] Maternal B vitamin intake during pregnancy and wheeze and eczema in Japanese infants aged 16-24 months : The Osaka Maternal and Child Health Study. (2011)
  • Author(s): Miyake Y, et al.
  • Journal Title: Pediatr Allergy Immunol Volume: 22 Pages: 69-74
  • Peer Reviewed
• [Journal Article] Lack of association of dairy food, calcium, and vitamin D intake with the risk of Parkinson's disease : a case-control study in Japan. (2011)
  • Author(s): Miyake Y, et al.
  • Journal Title: Parkinsonism Relat Disord Volume: 17 Pages: 112-116
  • Peer Reviewed
• [Journal Article] Association between breastfeeding and allergic disorders in Japanese children. (2010)
  • Author(s): Tanaka K, Miyake Y, Sasaki S.
  • Journal Title: Int J Tuberc Lung Dis Volume: 14 Pages: 513-518
  • Peer Reviewed
• [Journal Article] Dietary glycemic index is inversely associated with the risk of Parkinson's disease : a case-control study in Japan. (2010)
  • Author(s): Murakami K, Miyake Y, et al.
  • Journal Title: Nutrition Volume: 26 Pages: 515-521
  • Peer Reviewed
• [Journal Article] Dairy food, calcium, and vitamin D intake in pregnancy and wheeze and eczema in infants. (2010)
  • Author(s): Miyake Y, et al.
  • Journal Title: Eur Respir J Volume: 35 Pages: 1228-1234
  • Peer Reviewed
• [Journal Article] Consumption of vegetables, fruit, and antioxidants during pregnancy and wheeze and eczema in infants. (2010)
  • Author(s): Miyake Y, et al.
  • Journal Title: Allergy Volume: 65 Pages: 758-765
  • Peer Reviewed
• [Journal Article] Cigarette smoking TP53 Arg72Pro, TP53BP1 Asp353Glu, and the risk of lung cancer in a Japanese population. (2010)
  • Author(s): Kiyohara C, Horiuchi T, Miyake Y, et al.
  • Journal Title: Oncol Rep Volume: 23 Pages: 1361-1368
  • Peer Reviewed
• [Journal Article] Case-control study of risk of Parkinson's disease in relation to hypertension, hypercholesterolemia, and diabetes in Japan. (2010)
  • Author(s): Miyake Y, et al.
  • Journal Title: J Neurol Sci Volume: 293 Pages: 82-86
  • Peer Reviewed
• [Journal Article] Household smoking and dental caries in schoolchildren : the Ryukyus Child Health Study. (2010)
  • Author(s): Tanaka K, Miyake Y, et al.
  • Journal Title: BMC Public Health Volume: 10 Pages: 335-335
  • NAID: 120006980639
  • Peer Reviewed
• [Journal Article] Intake of dairy products and the prevalence of dental caries in young children. (2010)
  • Author(s): Tanaka K, Miyake Y, Sasaki S.
  • Journal Title: J Dent Volume: 38 Pages: 579-583
  • Peer Reviewed
• [Journal Article] GST polymorphisms, interaction with smoking and pesticide use, and risk for Parkinson's disease in a Japanese population. (2010)
  • Author(s): Kiyohara C, Miyake Y, et al.
  • Journal Title: Parkinsonism Relat Disord Volume: 16 Pages: 447-452
  • Peer Reviewed
• [Journal Article] Dietary intake of folate, vitamin B-6, vitamin B-12, and riboflavin and risk of Parkinson's disease : a case-control study in Japan. (2010)
  • Author(s): Murakami K, Miyake Y, et al.
  • Journal Title: Br J Nutr Volume: 104 Pages: 757-764
  • Peer Reviewed
• [Journal Article] LRRK2 Gly2385Arg polymorphism, cigarette smoking, and risk of sporadic Parkinson's disease : a case-control study in Japan. (2010)
  • Author(s): Miyake Y, et al.
  • Journal Title: J Neurol Sci Volume: 297 Pages: 15-18
  • Peer Reviewed
• [Journal Article] I Fish and n-3 PUFA intake and depressive symptoms : Ryukyus Child Health Study. (2010)
  • Author(s): Murakami K, Miyake Y, et al.
  • Journal Title: Pediatrics Volume: 126
  • Peer Reviewed
• [Journal Article] Dietary folate, riboflavin, vitamin B-6, and vitamin B-12 and depressive symptoms inearly adolescence : the Ryukyus Child Health Study. (2010)
  • Author(s): Murakami K, Miyake Y, et al.
  • Journal Title: Psychosom Med Volume: 72 Pages: 763-768
  • Peer Reviewed
• [Journal Article] Active and passive smoking and risk of Parkinson's disease. (2010)
  • Author(s): Tanaka K, Miyake Y, et al.
  • Journal Title: Acta Neurol Scand Volume: 122 Pages: 377-382
  • Peer Reviewed
• [Journal Article] Alcohol drinking and risk of Parkinson's disease : a case-control study in Japan. (2010)
  • Author(s): Fukushima W, Miyake Y, et al.
  • Journal Title: BMC Neurology I Volume: 10 Pages: 111-111
  • Peer Reviewed
• [Journal Article] Dietary fat intake and risk of Parkinson's disease : a case-control study in Japan (2010)
  • Author(s): Miyake Y, et al.
  • Journal Title: J Neurol Sci 288 Pages: 117-122
  • Peer Reviewed
• [Journal Article] Residential proximity to main roads during pregnancy and the risk of allergic disorders in Japanese infants : The Osaka Maternal and Child Health Study (2010)
  • Author(s): Miyake Y, et al.
  • Journal Title: Pediatr Allergy Immunol 21 Pages: 22-28
  • Peer Reviewed
• [Journal Article] Maternal meat and fat consumption during pregnancy and suspected atopic eczema in Japanese infants aged 3-4 months : The Osaka Maternal and Child Health Study (2010)
  • Author(s): Saito K, Yokoyama T, Miyake Y, et al.
  • Journal Title: Pediatr Allergy Immunol 21 Pages: 38-46
  • Peer Reviewed
• [Journal Article] Breastfeeding and atopic eczema in Japanese infants : The Osaka Maternal and Child Health Study (2009)
  • Author(s): Miyake Y, et al.
  • Journal Title: Pediatr Allergy Immunol 20 Pages: 234-241
  • Peer Reviewed
• [Journal Article] Sibship size and prevalence of allergic disorders in Japan : The Ryukyus Child Health Study (2009)
  • Author(s): Ohfuji S, Miyake Y, et al.
  • Journal Title: Pediatr Allergy Immunol 20 Pages: 377-384
  • Peer Reviewed
• [Journal Article] ADAM33 genetic polymorphisms and risk of atopic dermatitis among Japanese children (2009)
  • Author(s): Matsusue A, Kiyohara C, Tanaka K, Sasaki S, Miyake Y.
  • Journal Title: Clin Biochem 42 Pages: 477-483
  • Peer Reviewed
• [Journal Article] Fruit and vegetable intake and risk of amyotrophic lateral sclerosis in Japan (2009)
  • Author(s): Okamoto K, Kihira T, Kobashi G, Washio M, Sasaki S, Yokoyama T, Miyake Y, et al.
  • Journal Title: Neuroepidemiology 32 Pages: 251-256
  • Peer Reviewed
• [Journal Article] The effect of maternal smoking during pregnancy and postnatal household smoking on dental caries in young children (2009)
  • Author(s): Tanaka K, Miyake Y, et al.
  • Journal Title: J Pediatr 155 Pages: 410-415
  • Peer Reviewed
• [Journal Article] Monetary diet cost is associated with not only favorable but also unfavorable aspects of diet in pregnant Japanese women : the Osaka Maternal and Child Health Study (2009)
  • Author(s): Murakami K, Miyake Y, et al.
  • Journal Title: Environmental Health Insights 2 Pages: 27-35
  • Peer Reviewed
• [Journal Article] Lifestyle Factors and Risk of Amyotrophic Lateral Sclerosis : A Case-Control Study in Japan (2009)
  • Author(s): Okamoto K, Kihira T, Kondo T, Kobashi G, Washio M, Sasaki S, Yokoyama T, Wiyake Y, et al.
  • Journal Title: Ann Epidemiol 19 Pages: 359-364
  • Peer Reviewed
• [Journal Article] Maternal fat consumption during pregnancy and risk of wheeze and eczema in Japanese infants aged 16-24 months : The Osaka Maternal and Child Health Study (2009)
  • Author(s): Miyake Y, et al.
  • Journal Title: Thorax 64 Pages: 815-821
  • Peer Reviewed
• [Journal Article] Cigarette smoking, N-acetyltransferase 2 polymorphisms and systemic lupus erythematosus in a Japanese population (2009)
  • Author(s): Kiyohara C, Washio M, Horiuchi T, Tada Y, Asami T, Ide S, Takahashi H, Kobashi G, The Kyushu Sapporo SLE(KYSS)Study Group(Miyake Y, 29 authors listed in Appendix)
  • Journal Title: Lupus 18 Pages: 630-638
  • Peer Reviewed
• [Journal Article] Cigarette smoking, STAT4 and TNFRSF1B polymorphisms, and systemic lupus erythematosus in a Japanese population (2009)
  • Author(s): Kiyohara C, Washio M, Horiuchi T, Tada Y, Asami T, Ide S, Atsumi T, Kobashi G, Takahashi H, The Kyushu Sapporo SLE(KYSS)Study Group(Miyake Y, 33 authors listed in Appendix)
  • Journal Title: J Rheumatol 36 Pages: 2195-2203
  • Peer Reviewed
• [Journal Article] Combination of TNF-RII, CYP1A1 and GSTM1 polymorphisms and the risk of Japanese SLE : findings from the KYSS study (2009)
  • Author(s): Horiuchi T, Washio M, Kiyohara C, Tsukamoto H, Tada Y, Asami T, Ide S, Kobashi G, Takahashi H, The Kyushu Sapporo SLE Study Group(Miyake Y, 29 authors listed in Appendix)
  • Journal Title: Rheumatology 48 Pages: 1045-1049
  • Peer Reviewed
• [Journal Article] ADAM33 polymorphisms, smoking, and asthma in Japanese women : Kyushu Okinawa Maternal and Child Health Study
  • Author(s): Miyake Y, Tanaka K, Arakawa M.
  • Journal Title: Int J Tuberc Lung Dis Volume: (in press)
  • Peer Reviewed
• [Presentation] 妊娠中抗酸化物質摂取と子の喘鳴及びアトピー性皮膚炎発症との関連:大阪母子保健研究 (2010)
  • Author(s): 三宅吉博, 他
  • Organizer: 第60回日本アレルギー学会秋季学術大会
  • Place of Presentation: 東京
  • Year and Date: 2010-11-27
• [Presentation] シンポジウム1.アレルギー疾患の発症はどこまで抑えられるか-遺伝要因と環境要因の面から-シンポジスト.アレルギー疾患における遺伝要因と環境要因の交互作用:日本人のエビデンスの一例 (2010)
  • Author(s): 三宅吉博
  • Organizer: 第60回日本アレルギー学会秋季学術大会
  • Place of Presentation: 東京
  • Year and Date: 2010-11-25
• [Presentation] シンポジウム1.アレルギー疾患の発症はどこまで抑えられるか-遺伝要因と環境要因の面から-.アレルギー疾患における遺伝要因と環境要因の交互作用:日本人のエビデンスの一例 (2010)
  • Author(s): 三宅吉博
  • Organizer: 第60回日本アレルギー学会秋季学術大会
  • Place of Presentation: 東京
  • Year and Date: 2010-11-25
• [Presentation] 妊娠中乳製品、カルシウム、ビタミンD摂取と子の喘鳴及びアトピー性皮膚炎発症との関連:大阪母子保健研究 (2010)
  • Author(s): 三宅吉博, 他
  • Organizer: 第22回日本アレルギー学会春季臨床大会
  • Place of Presentation: 京都
  • Year and Date: 2010-05-08
• [Presentation] 琉球小児健康調査 (2009)
  • Author(s): 三宅吉博
  • Organizer: 第56回日本学校保健学会
  • Place of Presentation: 那覇市
  • Year and Date: 2009-11-28
• [Presentation] 食べ物とアレルギー:日本人のエビデンス (2009)
  • Author(s): 三宅吉博
  • Organizer: 日本農芸化学学会関西・中四国・西日本支部、日本栄養・食糧学会九州・沖縄支部、日本食品科学工学会西日本支部、2009年度合同沖縄大会
  • Place of Presentation: 那覇市
  • Year and Date: 2009-10-30
• [Presentation] 女性の栄養:妊婦・乳児の栄養とアレルギー疾患の関連:わが国における栄養疫学研究からの知見 (2009)
  • Author(s): 三宅吉博
  • Organizer: 第33回日本産科婦人科栄養・代謝研究会
  • Place of Presentation: 金沢市
  • Year and Date: 2009-07-31
• [Presentation] 妊娠中脂肪酸摂取と16-24ヶ月時喘鳴及び湿疹リスクとの関連:大阪母子保健研究 (2009)
  • Author(s): 三宅吉博、他
  • Organizer: 第21回日本アレルギー学会春季臨床大会
  • Place of Presentation: 岐阜市
  • Year and Date: 2009-06-05
• [Remarks]
  • URL: http://www.med.fukuoka-u.ac.jp/p_health/basic/index-j.htm