Effects of environmental chemicals on differentiation of helper-T 17 cells via retinoic acid receptor-related orphan receptors

• Project/Area Number: 21590675
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Hygiene
• Research Institution: Hokkaido Institute of Public Health
• Principal Investigator: KOJIMA Hiroyuki 北海道立衛生研究所, 理化学部, 主査(有害化学物質) (10414286)
• Co-Investigator(Kenkyū-buntansha): TAKEUCHI Shinji 北海道立衛生研究所, 理化学部, 研究職員 (20414287) ; MUROMOTO Ryuta 北海道大学, 大学院・薬学研究院, 助教 (30455597)
• Project Period (FY): 2009 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000); Fiscal Year 2011: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2009: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
• Keywords: 環境保健 / 環境化学物質 / 核内受容体 / ROR / Th17 / IL-17

Research Abstract

The retinoic acid receptor-related orphan receptorsαandγ(RORαand RORγ), are key regulators of helper T(Th) 17 cell differentiation, which is involved in the innate immune system and autoimmune disorders. In this study, we found that several azole-type fungicides and phytochemicals have RORα/γinverse agonistic activity and RORα/γagonistic activity, respectively. In addition, we found that these RORα/γinverse agonists and RORα/γagonists respectively show the inhibitory and enhanced effect on the gene expression of interleukin(IL)-17, which mediates the function of Th17 cells. These results suggest that some of environmental chemicals might regulate IL-17 production via RORα/γ.

Research Products

• [Journal Article] Inhibitory effects of azole-type fungicides on interleukin-17 gene expression via retinoic acid receptor-related orphan receptorsαandγ (2012)
  • Author(s): Kojima H, Muromoto R, Takahashi M, Takeuchi S, Takeda Y, Jetten AM, and Matsuda T.
  • Journal Title: Toxicol. Appl. Pharmacol. Volume: 259 Issue: 3 Pages: 338-345
  • DOI: 10.1016/j.taap.2012.01.011
  • Peer Reviewed
• [Journal Article] Characterization of steroid hormone receptor activities in 100 hydroxylated polychlorinated biphenyls, including congeners identified in humans (2011)
  • Author(s): Takeuchi S, Shiraishi F, Kitamura S, Kuroki H, Jin K and Kojima H.
  • Journal Title: Toxicology Volume: 280 Issue: 2-3 Pages: 112-121
  • DOI: 10.1016/j.tox.2011.08.001
  • Peer Reviewed
• [Journal Article] Involvement of tyrosine kinase-2 in both the IL-12/Th1 and IL-23/Th17 axes in vivo (2011)
  • Author(s): Ishizaki M, Akimoto T, Muromoto R, Yokoyama M, Ohshiro Y, Sekine Y, Maeda H, Shimoda K, Oritani K and Matsuda T.
  • Journal Title: J. Immunol. Volume: 187 Issue: 1 Pages: 181-189
  • DOI: 10.4049/jimmunol.1003244
  • Peer Reviewed
• [Journal Article] Determination of dioxin concentrations in fish and seafood samples using a highly sensitive reporter cell line, DR-EcoScreen cells (2011)
  • Author(s): Kojima H, Takeuchi S, Tsutsumi T, Yamaguchi K, Anezaki K, Kubo K, Iida M, Takahashi T, Kobayashi S, Jin K and Nagai T.
  • Journal Title: Chemosphere Volume: 83 Issue: 6 Pages: 753-759
  • DOI: 10.1016/j.chemosphere.2011.02.062
  • Peer Reviewed
• [Journal Article] Comparative study of human and mouse pregnane X receptor agonistic activity in 200 pesticides using reporter gene assays (2011)
  • Author(s): Kojima H, Sata F, Takeuchi S, Sueyoshi T and Nagai T.
  • Journal Title: Toxicology Volume: 280 Issue: 3 Pages: 77-87
  • DOI: 10.1016/j.tox.2010.11.008
  • Peer Reviewed
• [Journal Article] Comparative Study of Human and Mouse Pregnane X Receptor Agonistic Activity in 200 Pesticides Using Reporter Gene Assays (2011)
  • Author(s): Hiroyuki Kojima, Fumihiro Sata, Shinji Takeuchi, Tatsuya Sueyoshi, Tadanori Nagai
  • Journal Title: Toxicology Volume: VOL.280 Pages: 77-87
  • Peer Reviewed
• [Journal Article] Determination of Dioxin Concentrations in Fish and Seafood Samples Using a Highly Sensitive Reporter Cell Line, DR-EcoScreen Cells (2011)
  • Author(s): Hiroyuki Kojima, Shinji Takeuchi, Tomoaki Tsutsumi, Katsuyuki Yamaguchi, Katsunori Anezaki, Keiko Kubo, Mitsuru Iida, Tetsuo Takahashi, Satoshi Kobayashi, Kazuo Jin, Tadanori Nagai
  • Journal Title: Chemosphere Volume: VOL.83 Pages: 753-759
  • Peer Reviewed
• [Journal Article] Noncanonical K27-Linked Polyubiquitination of TIEG1 Regulates Foxp3 Expression and Tumor Growth (2011)
  • Author(s): Dong-Jun Peng, Minghui Zeng, Ryuta Muromoto, Tadashi Matsuda, Kazuya Shimoda, Malayannan Subramaniam, Thomas C.Spelsberg, Wei-Zen Wei, K.Venuprasad
  • Journal Title: Journal of Immunology Volume: VOL.186 Pages: 5638-5647
  • Peer Reviewed
• [Journal Article] Endocrine-disrupting potential of pesticides via nuclear receptors and aryl hydrocarbon receptor (2010)
  • Author(s): Kojima H, Takeuchi S. and Nagai T.
  • Journal Title: J. Health Sci. Volume: 56(4) Pages: 374-386
  • NAID: 130000303536
  • URL: https://www.jstage.jst.go.jp/article/jhs/56/4/56_4_374/_pdf
  • Peer Reviewed
• [Journal Article] 農薬による核内受容体RORα/γを介したIL-17遺伝子発現に及ぼす影響 (2010)
  • Author(s): 小島弘幸、武内伸治、高橋美妃、室本竜太
  • Journal Title: ImmunoTox Letter(日本免疫毒性学会) Volume: 15(2) Pages: 4-6
  • URL: http://www.immunotox.org/immunotoxletter/pdf/30vol15no2-2010J.pdf
  • Peer Reviewed
• [Journal Article] 生体異物センサー;PXRとCARを介した内分泌撹乱作用 (2010)
  • Author(s): 小島弘幸
  • Journal Title: Endocrine Disrupter NEWS LETTER(環境ホルモン学会) Volume: 13(1) Pages: 4-4
  • URL: http://www.jsedr.jp/newsletter/news1.htm#13-1
• [Journal Article] Functional involvement of Daxx in gp130-mediated cell growth and survival in BaF3 cells (2010)
  • Author(s): Muromoto R, Kuroda M, Togi S, Sekine Y, Nanbo A, Shimoda K, Oritani K and Matsuda T.
  • Journal Title: Eur. J. Immunol Volume: 40 Issue: 12 Pages: 3570-3580
  • DOI: 10.1002/eji.201040688
  • NAID: 120002646892
  • Peer Reviewed
• [Journal Article] Functional Involvement of Daxx in gp130-mediated Cell Growth and Survival in BaF3 Cells (2010)
  • Author(s): Ryuta Muromoto, Makoto Kuroda, Sumihito Togi, Yuichi Sekine, Asuka Nanbo, Kazuya Shimoda, Kenji Oritani, Tadashi Matsuda
  • Journal Title: European Journal of Immunology Volume: VOL.40 Pages: 3570-3580
  • NAID: 120002646892
  • Peer Reviewed
• [Journal Article] [Minireview]Endocrine-disrupting Potential of Pesticides via Nuclear Receptors and Aryl Hydrocarbon Receptor (2010)
  • Author(s): Hiroyuki Kojima, Shinji Takeuchi, Tadanori Nagai
  • Journal Title: Journal of Health Science (掲載確定, 印刷中)
  • Peer Reviewed
• [Journal Article] 水性塗料成分1-メチル-2-ピロリドン及びテキサノールによる新築小学校の室内空気汚染 (2010)
  • Author(s): 小林智、武内伸治、小島弘幸、高橋哲夫、神和夫、秋津裕志、伊佐治信一
  • Journal Title: 日本室内環境学会誌 (掲載確定, 印刷中)
  • NAID: 40017162386
  • Peer Reviewed
• [Journal Article] Application of a bioassay using DR-EcoScreen cells to the determination of dioxins in ambient air : A comparative study with HRGC-HRMS analysis (2009)
  • Author(s): Anezaki K, Yamaguchi K, Takeuchi S, Iida M, Jin K. and Kojima H.
  • Journal Title: Environ. Sci. Technol Volume: 43 Issue: 19 Pages: 7478-7483
  • DOI: 10.1021/es901003b
  • Peer Reviewed
• [Journal Article] Nuclear hormone receptor activity of brominated diphenyl ethers and their hydroxylated and methoxylated metabolites in transactivation assays using Chinese hamster ovary cells (2009)
  • Author(s): Kojima H, Takeuchi S, Uramaru N, Sugihara K, Yoshida T. and Kitamura S.
  • Journal Title: Environ. Health Perspect Volume: 117 Issue: 8 Pages: 1210-1218
  • DOI: 10.1289/ehp.0900753
  • Peer Reviewed
• [Journal Article] The exon-junction complex proteins, Y14 and MAGOH regulate STAT3 activation (2009)
  • Author(s): Muromoto R, Taira N, Ikeda O, Shiga K, Kamitani S, Togi S, Kawakami S, Sekine Y, Nanbo A, Oritani K. and Matsuda T.
  • Journal Title: Biochem. Biophys. Res. Commun Volume: 382 Issue: 1 Pages: 63-68
  • DOI: 10.1016/j.bbrc.2009.02.127
  • NAID: 120001164606
  • Peer Reviewed
• [Journal Article] Nuclear Hormone Receptor Activity of Brominated Diphenyl Ethers and Their Hydroxylarted and Methoxylated Metabolites in Transactivation Assays Using Chinese Hamster Ovary Cells (2009)
  • Author(s): Hiroyuki Kojima, Shinji Takeuchi, Naoto Uramaru, Kazumi Sugihara, Takahiko Yoshida, Shigeyuki Kitamura
  • Journal Title: Environmental Health Perspectives VOL.117 Pages: 1210-1218
  • Peer Reviewed
• [Journal Article] Application of a Bioassay Using DR-EcoScreen Cells to the Determination of Dioxins in Ambient Air : A Comparative Study with HRGC-HRMS Analysis (2009)
  • Author(s): Katsunori Anezaki, Katsuyuki Yamaguchi, Shinji Takeuchi, Mitsuru Iida, Kazuo Jin, Hiroyuki Kojima
  • Journal Title: Environmental Science & Technology VOL.43 Pages: 7478-7483
  • Peer Reviewed
• [Journal Article] Signal-transducing Adaptor Protein-2 Regulates Stromal Cell-derived Factor-1 Alpha-induced Chemotaxis in T Cells (2009)
  • Author(s): Yuichi Sekine, Osamu Ikeda, Satoshi Tsuji, Chikako Yamamoto, Ryuta Muromoto, Asuka Nanbo, Kenji Oritani, Akihiko Yoshimura, Tadashi Matsuda
  • Journal Title: Journal of Immunology VOL.183 Pages: 7966-7974
  • Peer Reviewed
• [Journal Article] The Exon-junction Complex Proteins, Y14 and MAGOH Regulate STAT3 Activation (2009)
  • Author(s): Ryuta Muromoto, Naohisa Taira, Osamu Ikeda, Kaname Shiga, Shinya Kamitani, Sumihito Togi, Shiho Kawakami, Yuichi Sekine, Asuka Nanbo, Kenji Oritani, Tadashi Matsuda
  • Journal Title: Biochemical and Biophysical Research Communications VOL.382 Pages: 63-68
  • NAID: 120001164606
  • Peer Reviewed
• [Presentation] 環境化学物質における核内受容体RORα/γ活性の探索とIL-17遺伝子発現への影響 (2012)
  • Author(s): 小島弘幸、室本竜太、高橋美妃、武内伸治、松田正
  • Organizer: 日本薬学会第132年会総会
  • Place of Presentation: 札幌市(北海道大学)
  • Year and Date: 2012-03-31
• [Presentation] 室内空気中から検出された光重合開始剤及びその類似化合物の核内受容体を介した作用 (2012)
  • Author(s): 武内伸治、小林智、小島弘幸
  • Organizer: 日本薬学会第132年会総会
  • Place of Presentation: 札幌市(北海道大学)
  • Year and Date: 2012-03-31
• [Presentation] 環境化学物質における核内受容体RORα/γ活性の探索とIL-17遺伝子発現への影響 (2012)
  • Author(s): 小島弘幸、室本竜太、高橋美妃、武内伸治、松田正
  • Organizer: 日本薬学会第132年会総会
  • Place of Presentation: 北海道大学(札幌市)
  • Year and Date: 2012-03-31
• [Presentation] 室内空気中から検出された光重合開始剤及びその類似化合物の核内受容体を介した作用 (2012)
  • Author(s): 武内伸治、小林智、小島弘幸
  • Organizer: 日本薬学会第132年会総会
  • Place of Presentation: 北海道大学(札幌市)
  • Year and Date: 2012-03-31
• [Presentation] 炎症性サイトカインIL-17産生に及ぼすBiochanin Aの影響に関する研究 (2012)
  • Author(s): 高橋美妃、室本竜太、小島弘幸、武内伸治、松田正
  • Organizer: 日本薬学会第132年会総会
  • Place of Presentation: 札幌市(北海道大学)
  • Year and Date: 2012-03-29
• [Presentation] 炎症性サイトカインIL-17産生に及ぼすBiochanin Aの影響に関する研究 (2012)
  • Author(s): 高橋美妃、室本竜太、小島弘幸、武内伸治、松田正
  • Organizer: 日本薬学会第132年会総会
  • Place of Presentation: 北海道大学(札幌市)
  • Year and Date: 2012-03-29
• [Presentation] Characterization of steroid hormone receptor activities in 100 hydroxylated polychlorinated biphenyls, including congeners identified in humans (2012)
  • Author(s): Shinji Takeuchi, Fujio Shiraishi, Shigeyuki Kitamura, Hiroaki Kuroki, Kazuo Jin, Hiroyuki Kojima
  • Organizer: The 51st Annual Meeting of the Society of Toxicology (SOT)
  • Place of Presentation: San Francisco
  • Year and Date: 2012-03-14
• [Presentation] Inhibitory effects of azole-type fungicides on interleukin-17 gene expression via retinoic acid receptor-related orphan receptors α and γ (2012)
  • Author(s): Hiroyuki Kojima, Ryuta Muromoto, Miki Takahashi, Shinji Takeuchi, Yukimasa Takeda, Anton M.Jetten, Tadashi Matsuda
  • Organizer: The 51st Annual Meeting of the Society of Toxicology (SOT)
  • Place of Presentation: San Francisco
  • Year and Date: 2012-03-13
• [Presentation] Inhibitory effects of azole-type fungicides on interleukin-17 gene expression via retinoic acid receptor-related orphan receptorsαandγ (2012)
  • Author(s): Kojima H, Muromoto R, Takahashi M, Takeuchi S, Takeda Y, Jetten AM, and Matsuda T.
  • Organizer: The 51st Annual Meeting of the Society of Toxicology(SOT)
  • Place of Presentation: San Francisco, USA
• [Presentation] Characterization of steroid hormone receptor activities in 100 hydroxylated polychlorinated biphenyls, including congeners identified in humans (2012)
  • Author(s): Takeuchi S, Shiraishi F, Kitamura S, Kuroki H, Jin K and Kojima H.
  • Organizer: The 51st Annual Meeting of the Society of Toxicology(SOT)
  • Place of Presentation: San Francisco, USA
• [Presentation] RORα/γ依存的なIL-17産生に及ぼすBiochanin Aの影響 (2011)
  • Author(s): 小島弘幸、室本竜太、高橋美妃、武内伸治、松田正
  • Organizer: 環境ホルモン学会第14回研究発表会
  • Place of Presentation: 東京都(東京大学山上会館)
  • Year and Date: 2011-12-01
• [Presentation] RORα/γ依存的なIL-17産生に及ぼすBiochanin Aの影響 (2011)
  • Author(s): 小島弘幸、室本竜太、高橋美妃、武内伸治、松田正
  • Organizer: 環境ホルモン学会第14回研究発表会
  • Place of Presentation: 東京大学山上会館(東京都)
  • Year and Date: 2011-12-01
• [Presentation] 室内空気中化学物質における核内受容体活性のプロファイル (2011)
  • Author(s): 武内伸治、小林智、小島弘幸
  • Organizer: フォーラム2011衛生薬学・環境トキシコロジー(日本薬学会主催)
  • Place of Presentation: 金沢市(金沢エクセルホテル東急)
  • Year and Date: 2011-10-28
• [Presentation] 室内空気中化学物質における核内受容体活性のプロファイル (2011)
  • Author(s): 武内伸治、小林智、小島弘幸
  • Organizer: フォーラム2011衛生薬学・環境トキシコロジー(日本薬学会主催)
  • Place of Presentation: 金沢エクセルホテル東急(金沢市)
  • Year and Date: 2011-10-28
• [Presentation] RORγt依存的なIL-17遺伝子発現誘導に対するイソフラボン類の影響 (2011)
  • Author(s): 小島弘幸、室本竜太、高橋美妃、武内伸治、松田正
  • Organizer: 第18回日本免疫毒性学会
  • Place of Presentation: 千葉市(千葉大学けやき会館)
  • Year and Date: 2011-09-08
• [Presentation] RORγt依存的なIL-17遺伝子発現誘導に対するイソフラボン類の影響 (2011)
  • Author(s): 小島弘幸、室本竜太、高橋美妃、武内伸治、松田正
  • Organizer: 第18回日本免疫毒性学会
  • Place of Presentation: 千葉大学けやき会館(千葉市)
  • Year and Date: 2011-09-08
• [Presentation] TYK2とJun activation domain-binding protein 1(JAB1)の機能的相互作用の解析 (2011)
  • Author(s): 室本竜太、高橋美妃、坪内真知子、関根勇一、南保明日香、松田正
  • Organizer: 日本薬学会第131年会総会
  • Place of Presentation: グランシップ(静岡市)
  • Year and Date: 2011-03-31
• [Presentation] トリクロサン及びその塩素化誘導体の13種類の核内受容体への作用 (2011)
  • Author(s): 武内伸治、兼俊明夫、小林智、北村繁幸、小島弘幸
  • Organizer: 日本薬学会第131年会総会
  • Place of Presentation: 静岡市(ツインメッセ静岡)
  • Year and Date: 2011-03-30
• [Presentation] トリクロサン及びその塩素化誘導体の13種類の核内受容体への作用 (2011)
  • Author(s): 武内伸治、兼俊明夫、小林智、北村繁幸、小島弘幸
  • Organizer: 日本薬学会第131年会総会
  • Place of Presentation: ツインメッセ静岡(静岡市)
  • Year and Date: 2011-03-30
• [Presentation] 遺伝子導入細胞を用いた環境・食品試料中のダイオキシン類簡易測定法の開発 (2011)
  • Author(s): 小島弘幸
  • Organizer: 道央バイオ研究交流会・平成22年度研究発表会
  • Place of Presentation: 恵庭市(恵庭リサーチビジネスパーク・センタービル)
  • Year and Date: 2011-02-25
• [Presentation] 遺伝子導入細胞を用いた環境・食品試料中のダイオキシン類簡易測定法の開発 (2011)
  • Author(s): 小島弘幸
  • Organizer: 道央バイオ研究交流会「平成22年度研究発表会」
  • Place of Presentation: 恵庭リサーチビジネスパーク・センタービル(恵庭市)
  • Year and Date: 2011-02-25
• [Presentation] 農薬による核内受容体RORα/γインバースアゴニスト活性と免疫系への影響 (2010)
  • Author(s): 小島弘幸、武内伸治、高橋美妃、室本竜太
  • Organizer: 環境ホルモン学会第13回研究発表会
  • Place of Presentation: 東京都(東京大学山上会館)
  • Year and Date: 2010-12-16
• [Presentation] 農薬による核内受容体RORα/γインバースアゴニスト活性と免疫系への影響 (2010)
  • Author(s): 小島弘幸、武内伸治、高橋美妃、室本竜太
  • Organizer: 環境ホルモン学会 第13回研究発表会
  • Place of Presentation: 東京大学山上会館(東京都)
  • Year and Date: 2010-12-16
• [Presentation] ビスフェノールA関連物質の核内受容体PXR/CARを介した転写活性に及ぼす影響 (2010)
  • Author(s): 小島弘幸、佐能正剛、武内伸治、杉原数美、北村繁幸
  • Organizer: フォーラム2010衛生薬学・環境トキシコロジー(日本薬学会主催)
  • Place of Presentation: 東京都(星薬科大学)
  • Year and Date: 2010-09-10
• [Presentation] ビスフェノールA関連物質の核内受容体PXR/CARを介した転写活性に及ぼす影響 (2010)
  • Author(s): 小島弘幸、佐能正剛、武内伸治、杉原数美、北村繁幸
  • Organizer: フォーラム2010 衛生薬学・環境トキシコロジー(日本薬学会主催)
  • Place of Presentation: 星薬科大学(東京都)
  • Year and Date: 2010-09-10
• [Presentation] 農薬200物質におけるレチノイド関連オーファン受容体(ROR)活性の探索とIL-17産生に及ぼす影響 (2010)
  • Author(s): 小島弘幸、武内伸治、高橋美妃、室本竜太
  • Organizer: 第17回日本免疫毒性学会学術大会
  • Place of Presentation: つくば市(国立環境研究所・大山記念ホール)
  • Year and Date: 2010-09-09
• [Presentation] 農薬200物質におけるレチノイド関連オーファン受容体(ROR)活性の探索とIL-17産生に及ぼす影響 (2010)
  • Author(s): 小島弘幸、武内伸治、高橋美妃、室本竜太
  • Organizer: 第17回日本免疫毒性学会学術大会
  • Place of Presentation: 国立環境研究所・大山記念ホール(つくば市)
  • Year and Date: 2010-09-09
• [Presentation] Jun activation domain-binding protein 1 (JAB1)/CSN5 is involved in the regulation of type I interferon signaling (2010)
  • Author(s): Ryuta Muromoto, Maiko Nakajima, Machiko Tsubouchi, Yuichi Sekine, Kenji Oritani, Kazuya Shimoda, Tadashi Matsuda
  • Organizer: 14th International Congress of Immunology
  • Place of Presentation: Kobe International Exhibition Hall, Kobe, Japan
  • Year and Date: 2010-08-24
• [Presentation] Nuclear Hormone Receptor Activity of Brominated Diphenyl Ethers and Their Hydroxylarted and Methoxylated Metabolites Based on Transactivation Assays (2010)
  • Author(s): Hiroyuki Kojima, Shinji Takeuchi, Naoto Uramaru, Kazumi Sugihara, Takahiko Yoshida, Shigeyuki Kitamura
  • Organizer: 5th International Symposium on Brominated Flame Retardants
  • Place of Presentation: Kyoto University Clock Tower, Kyoto, Japan
  • Year and Date: 2010-04-08
• [Presentation] 臭素化難燃剤PBDE水酸化体の核内受容体アゴニスト及びアンタゴニスト活性 (2010)
  • Author(s): 小島弘幸、武内伸治、杉原数美、浦丸直人、北村繁幸
  • Organizer: 日本薬学会第130年会総会
  • Place of Presentation: 岡山市(桃太郎アリーナ)
  • Year and Date: 2010-03-30
• [Presentation] 臭素化難燃剤PBDE水酸化体の核内受容体アゴニスト及びアンタゴニスト活性 (2010)
  • Author(s): 小島弘幸、武内伸治、杉原数美、浦丸直人、北村繁幸
  • Organizer: 日本薬学会第130年会総会
  • Place of Presentation: 桃太郎アリーナ(岡山市)
  • Year and Date: 2010-03-30
• [Presentation] P.acnes誘導性肉芽腫形成におけるTyk2の役割 (2010)
  • Author(s): 黒田誠、室本竜太、松田正
  • Organizer: 日本薬学会第130年会総会
  • Place of Presentation: 就実大学(岡山市)
  • Year and Date: 2010-03-28
• [Presentation] Nuclear hormone receptor activity of brominated diphenyl ethers and their hydroxylarted and methoxylated metabolites based on transactivation assays (2010)
  • Author(s): Kojima H, Takeuchi S, Uramaru N, Sugihara K, Yoshida T and Kitamura S.
  • Organizer: 5th International Symposium on Brominated Flame Retardants
  • Place of Presentation: Kyoto University, Japan
• [Presentation] A new biological function of Jun activation domain-binding protein 1(JAB1)/CSN5 in the regulation of type I interferon signaling (2009)
  • Author(s): 室本竜太、関根勇一、織谷健司、下田和哉、松田正
  • Organizer: 第39回日本免疫学会総会・学術集会
  • Place of Presentation: 大阪市(大阪国際会議場)
  • Year and Date: 2009-12-02
• [Presentation] A new biological function of Jun activation domain-binding protein 1(JAB1)/CSN5 in the regulation of type I interferon signaling (2009)
  • Author(s): 室本竜太、関根勇一、織谷健司、下田和哉、松田正
  • Organizer: 第39回日本免疫学会総会・学術集会
  • Place of Presentation: 大阪国際会議場(大阪市)
  • Year and Date: 2009-12-02
• [Presentation] ピレスロイド系殺虫剤によるヒト及びマウスPXR/CARを介した転写活性の比較 (2009)
  • Author(s): 小島弘幸、武内伸治、佐田文宏
  • Organizer: フォーラム2009衛生薬学・環境トキシコロジー(日本薬学会主催)
  • Place of Presentation: 宜野湾市(沖縄コンベンションセンター)
  • Year and Date: 2009-11-06
• [Presentation] TR, PDIへの親和性に対する臭素化難燃剤の構造活性相関 (2009)
  • Author(s): 岩瀬恵理、佐能正剛、今岡進、岡田和嗣、加藤善久、小島弘幸、浦丸直人、杉原数美、北村繁幸、黒木広明、太田茂
  • Organizer: フォーラム2009衛生薬学・環境トキシコロジー(日本薬学会主催)
  • Place of Presentation: 沖縄コンベンションセンター(宜野湾市)
  • Year and Date: 2009-11-06
• [Presentation] ピレスロイド系殺虫剤によるヒト及びマウスPXR/CARを介した転写活性の比較 (2009)
  • Author(s): 小島弘幸、武内伸治、佐田文宏
  • Organizer: フォーラム2009衛生薬学・環境トキシコロジー(日本薬学会主催)
  • Place of Presentation: 沖縄コンベンションセンター(宜野湾市)
  • Year and Date: 2009-11-05
• [Presentation] 高感度レポーターアッセイ法を用いた環境化学物質の核内受容体活性の検出およびダイオキシン類生物検定法への適用 (2009)
  • Author(s): 小島弘幸
  • Organizer: 生物化学的測定研究会第14回学術シンポジウム
  • Place of Presentation: つくば市(つくばインフォメーションセンター)
  • Year and Date: 2009-10-30
• [Presentation] 高感度レポーターアッセイ法を用いた環境化学物質の核内受容体活性の検出およびダイオキシン類生物検定法への適用 (2009)
  • Author(s): 小島弘幸
  • Organizer: 生物化学的測定研究会第14回学術シンポジウム
  • Place of Presentation: つくばインフォメーションセンター(つくば市)
  • Year and Date: 2009-10-30
• [Presentation] Nuclear Hormone Receptor Activity of Brominated Diphenyl Ethers and Their Hydroxylarted and Methoxylated Metabolites in Transactivation Assays Using Chinese Hamster Ovary Cells (2009)
  • Author(s): Hiroyuki Kojima, Shinji Takeuchi, Naoto Uramaru, Kazumi Sugihara, Takahiko Yoshida, Shigeyuki Kitamura
  • Organizer: HORIBA International Conference/CDBIM Symposium : 21th Century Advances in the Molecular Toxicology of Environmental Chemicals and Pathogenesis of Disease
  • Place of Presentation: 東京大学鉄門記念講堂(東京都)
  • Year and Date: 2009-10-26
• [Presentation] 臭素化難燃剤PBDE及びそれら代謝物によるホルモン受容体を介した内分泌撹乱作用 (2009)
  • Author(s): 小島弘幸、武内伸治、浦丸直人、杉原数美、北村繁幸
  • Organizer: 日本薬学会北海道支部第132例会
  • Place of Presentation: 札幌市(札幌コンベンションセンター)
  • Year and Date: 2009-05-30
• [Presentation] 臭素化難燃剤PBDE及びそれら代謝物によるホルモン受容体を介した内分泌撹乱作用 (2009)
  • Author(s): 小島弘幸、武内伸治、浦丸直人、杉原数美、北村繁幸
  • Organizer: 日本薬学会北海道支部第132例会
  • Place of Presentation: 札幌コンベンションセンター(札幌市)
  • Year and Date: 2009-05-30
• [Presentation] Nuclear hormone receptor activity of brominated diphenyl ethers and their hydroxylarted and methoxylated metabolites in transactivation assays using Chinese hamster ovary cells (2009)
  • Author(s): Kojima H, Takeuchi S, Uramaru N, Sugihara K, Yoshida T and Kitamura S.
  • Organizer: HORIBA International Conference/CDBIM Symposium : 21th Century Advances in the Molecular Toxicology of Environmental Chemicals and Pathogenesis of Disease
  • Place of Presentation: Tokyo University, Japan