| Project/Area Number |
21590675
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Hygiene
|
|---|
| Research Institution | Hokkaido Institute of Public Health |
|---|
Principal Investigator |
KOJIMA Hiroyuki 北海道立衛生研究所, 理化学部, 主査(有害化学物質) (10414286)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
TAKEUCHI Shinji 北海道立衛生研究所, 理化学部, 研究職員 (20414287)
MUROMOTO Ryuta 北海道大学, 大学院・薬学研究院, 助教 (30455597)
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| Project Period (FY) |
2009 – 2011
|
| Project Status |
Completed (Fiscal Year 2011)
|
| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2011: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
|
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| Keywords | 環境保健 / 環境化学物質 / 核内受容体 / ROR / Th17 / IL-17 |
|---|
| Research Abstract |
The retinoic acid receptor-related orphan receptorsαandγ(RORαand RORγ), are key regulators of helper T(Th) 17 cell differentiation, which is involved in the innate immune system and autoimmune disorders. In this study, we found that several azole-type fungicides and phytochemicals have RORα/γinverse agonistic activity and RORα/γagonistic activity, respectively. In addition, we found that these RORα/γinverse agonists and RORα/γagonists respectively show the inhibitory and enhanced effect on the gene expression of interleukin(IL)-17, which mediates the function of Th17 cells. These results suggest that some of environmental chemicals might regulate IL-17 production via RORα/γ.
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