| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2011: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2009: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
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| Research Abstract |
It has been concerned that environmental chemicals might affect their effects over generation. Therefore, we examined this sense using rotenone models of hyperactive rat. Breeding female hyperactive rats with male ones produced hyperactive rats. Epigenetic modifying reagents altered rat motor activity as seen in rotenone-exposed rats. DNA array analyses indicated the pesticide altered the level of the molecules which are consisted of dopaminergic transduction pathway.
Thus, our study strongly suggests that motor activity could be regulated by epigenetics.
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