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A comparison between Japanese men and US men with regard to change in abdominal adipose tissue and progression of subclinical atherosclerosis

Research Project

Project/Area Number 21590688
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Public health/Health science
Research InstitutionShiga University of Medical Science

Principal Investigator

KADOWAKI Takashi  滋賀医科大学, 医学部, 客員助教 (30324578)

Project Period (FY) 2009 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2011: ¥260,000 (Direct Cost: ¥200,000、Indirect Cost: ¥60,000)
Fiscal Year 2010: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2009: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Keywords潜在性動脈硬化 / 中年男性 / メタボリックシンドローム / 国際共同研究 / 内臓脂肪 / 腹部脂肪 / 中年期男性 / 動脈硬化 / メタボリック症候群
Research Abstract

In this longitudinal study focusing on abdominal fat among men aged 40-49 years(Japanese men in Japan and Caucasian men in US), we quantified areas of subcutaneous adipose tissue(SAT), and visceral adipose tissue(VAT), using computed tomography scan. We then studied how change in SAT/VAT was correlated with changes in cardiovascular risk factors. Change in VAT among Japanese men was generally more correlated with changes in glucose, blood pressure, and triglycerides, compared to Caucasian men in US. This(indirectly) suggests that influence of VAT on incidence metabolic risk factors and/or metabolic syndrome may be stronger in Japanese men than in Caucasian men.

Report

(4 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • 2009 Annual Research Report
  • Research Products

    (13 results)

All 2012 2011

All Journal Article (5 results) (of which Peer Reviewed: 5 results) Presentation (8 results)

  • [Journal Article] The prevalence of aortic calcification in Japanese compared to white and Japanese-American middle-aged men is confounded by the amount of cigarette smoking2012

    • Author(s)
      El-Saed A, Curb JD, Kadowaki T. Okamura T, Sutton-Tyrrell K, Masaki K, Seto TB, Takamiya T, Choo J, Edmundowicz D, Evans RW, Fujiyoshi A, Nakamura Y, Miura K, Shin C, Kuller LH, Ueshima H, Sekikawa A.
    • Journal Title

      Intern J Cardiol

      Volume: (in press) Pages: 22240754-22240754

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Significant inverse associations of serum n-6 fatty acids with plasma plasminogen activator inhibitor-12012

    • Author(s)
      Lee S, Curb JD, Kadowaki T. Evans RW, Miura K, Takamiya T, Shin C, El-Saed A, Choo J, Fujiyoshi A, Otake T, Kadowaki S, Seto T, Masaki K, Edmundowicz D, Ueshima H, Kuller LH, Sekikawa A.
    • Journal Title

      Br J Nutr

      Volume: 4 Pages: 567-72

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] The prevalence of aortic calcification in Japanese compared to white and Japanese-American middle-aged men is confounded by the amount of cigarette smoking2012

    • Author(s)
      El-Saed A, Curb JD, Kadowaki T., et.al.
    • Journal Title

      Intern J Cardiol

      Volume: (In press)

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Significant inverse associations of serum n-6 fatty acids with plasma plasminogen activator inhibitor-12012

    • Author(s)
      Lee S, Curb JD, Kadowaki T., et.Al.
    • Journal Title

      Br J Nutr.

      Volume: 4 Pages: 567-72

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Ethnic difference in liver fat content : A cross-sectional observation among Japanese American in Hawaii, Japanese in Japan, and non-Hispanic whites in United States2011

    • Author(s)
      Azumaa K, Curb JD, Kadowaki T.
    • Journal Title

      Obesity Research & Clinical Practice

      Volume: (in press)

    • URL

      http://dx.doi.org/10.1016/j.orcp.2011.1

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Presentation] Coronary artery calcification is not uncommon among apparently healthy Japanese men and women2012

    • Author(s)
      Akira Fujiyoshi A; Katsuyuki Miura; Takashi Kadowaki, et.al.
    • Organizer
      第16回国際動脈硬化シンポジウム
    • Place of Presentation
      シドニー(オーストラリア)
    • Year and Date
      2012-03-28
    • Related Report
      2011 Annual Research Report
  • [Presentation] Lipoprotein-associated Phospholipase A2 Related to the Risk of Subclinical Carotid Atherosclerosis in a General Male Japanese population2012

    • Author(s)
      Hirotsugu Ueshima, Takashi Kadowaki, et.al.
    • Organizer
      第16回国際動脈硬化シンポジウム
    • Place of Presentation
      シドニー(オーストラリア)
    • Year and Date
      2012-03-28
    • Related Report
      2011 Annual Research Report
  • [Presentation] Incidence of coronary artery calcification and its association with eicosapentaenoic acids from the ERA JUMP Study2012

    • Author(s)
      Sekikawa A, Kadowaki T, Ueshima H. et al.
    • Organizer
      米国心臓病協会(AHA)循環器疫学学会2012
    • Place of Presentation
      サンディエゴ、米国
    • Year and Date
      2012-03-24
    • Related Report
      2011 Final Research Report
  • [Presentation] 肥満と冠動脈石灰化の関連は日韓米4集団で異なるか:国際横断研究2012

    • Author(s)
      藤吉朗、関川暁、門脇崇、上島弘嗣, 他
    • Organizer
      第22回日本疫学会学術総会
    • Place of Presentation
      東京
    • Year and Date
      2012-01-27
    • Related Report
      2011 Final Research Report
  • [Presentation] 肥満と冠動脈石灰化の関連は日韓米4集団で異なるか:国際砲弾研究2012

    • Author(s)
      藤吉朗、関川暁、門脇崇, ほか
    • Organizer
      第22回日本疫学会学術総会
    • Place of Presentation
      東京
    • Year and Date
      2012-01-27
    • Related Report
      2011 Annual Research Report
  • [Presentation] 上島弘嗣ほか「日米地域住民対象コホートにおけるCTによる冠動脈石灰化スコアの比較可能性検討」2011

    • Author(s)
      藤吉朗、関川暁、大久保孝義、三浦克之、門脇崇、上島弘嗣、他ERAJUMP, リサーチグループ
    • Organizer
      第47回日本循環器病予防学会・日本循環器管理研究協議会総会
    • Place of Presentation
      福岡
    • Year and Date
      2011-06-03
    • Related Report
      2011 Final Research Report
  • [Presentation] 日米地域住民対象コホートにおけるCTによる冠動脈石灰化スコアの比較可能性検討2011

    • Author(s)
      藤吉朗、門脇崇、門脇紗也佳, ほか
    • Organizer
      第47回日本循環器病予防学会・日本循環器管理研究協議会総会
    • Place of Presentation
      福岡
    • Year and Date
      2011-06-03
    • Related Report
      2011 Annual Research Report
  • [Presentation] A Cross-Sectional Association of Visceral Adipose Tissue with Coronary Artery Calcification among White, Japanese-American, Japanese, and Korean Men2011

    • Author(s)
      藤吉朗、門脇崇、上島弘嗣, 他
    • Organizer
      米国心臓病協会(AHA)循環器疫学学会2011
    • Place of Presentation
      アトランタ、米国
    • Year and Date
      2011-03-25
    • Related Report
      2011 Final Research Report 2010 Annual Research Report

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Published: 2009-04-01   Modified: 2016-04-21  

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