Molecular epidemiological study on the evaluation of long-term intake of folic acid, in order to reduce the risk of Down syndrome
| Project/Area Number |
21590699
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Public health/Health science
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| Research Institution | Nagasaki University |
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Principal Investigator |
TAKAMURA Noboru 長崎大学, 医歯薬学総合研究科, 准教授 (30295068)
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| Co-Investigator(Kenkyū-buntansha) |
MASUZAKI Hideaki 長崎大学, 医歯薬学総合研究科, 教授 (00173740)
OHISHI Kazuyo 長崎大学, 医歯薬学総合研究科, 教授 (00194069)
HAYASHIDA Naomi 長崎大学, 医歯薬学総合研究科, 助教 (00420638)
和田 光弘 長崎大学, 大学院・医歯薬学総合研究科, 准教授 (40295093)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2009: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 母子保健 / ダウン症候群 / 葉酸 |
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| Research Abstract |
We showed that genetic effects of MTHFR polymorphism on homosysteine metabolism is different in three generations, i. e. new born babies, mothers and elderies.
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Report
(4 results)
Research Products
(74 results)
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[Journal Article] Longitudinal study to identify factors predicting health-related quality of life in knee osteoarthritis among community-dwelling women in Japan : The Hizen-Oshima Study2011
Author(s)
Norimatsu T, Osaki M, Tomita M, Ye Z, Abe Y, Honda S, Kanagae M, Mizukami S, Takamura N, Kusano Y, Shindo H, Aoyagi K
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Journal Title
Orthopedics
Volume: 34(9)
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[Journal Article] Background radiation and individual dosimetry in the costal area of Tamil Nadu, India2011
Author(s)
Matsuda N, Brahmanandhan GM, Yoshida M, Takamura N, Suyama A, Koguchi Y, Juto N, Raj YL, Winsley G, Selvasekarapandian S
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Journal Title
Radiat Prot Dosimetry
Volume: 146(1-3)
Pages: 314-7
NAID
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[Journal Article] Mutational screening of the BRCA1 gene in sporadic breast cancer in the Kazakhstan population2011
Author(s)
Akilzhanova A, Meirmanov S, Zhunussova T, Nakashima M, Takamura N, Akanov Z, Masadykov A, Sandybaev M, Ramankulov E, Yamashita S, Sekine I
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Journal Title
Breast J
Volume: 17(3)
Pages: 328-30
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[Journal Article] The association between atherosclerosis and plasma homocysteine concentration in the general population residing on remote islands in Japan2011
Author(s)
Nakazato M, Takamura N, Kadota K, Yamasaki H, Mukae H, Kusano Y, Nakashima K, Ozono Y, Aoyagi K, Kohno S, Maeda T
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Journal Title
Acta Med Nagasaki
Volume: 55(1)
Pages: 47-54
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[Journal Article] Current concentration of artificial radionuclides and estimated radiation doses around the Chernobyl Nuclear Power Plant, the Semipalatinsk Nuclear Testing Site, and in Nagasaki2011
Author(s)
Taira Y, Hayashida N, Brahmanandhan GM, Nagayama Y, Yamashita S, Takahashi J, Gutevitc A, Kozlovsky A, Urazalin M, Takamura N
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Journal Title
J Rad Res
Volume: 52(1)
Pages: 88-95
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[Journal Article] The FOXE1 locus is a major genetic determinant for radiation-related thyroid carcinoma in Chernobyl2010
Author(s)
Takahashi M, Saenko V, Rogounovitch TI, Kawaguchi T, Drozd VM, Takigawa-Imamura H, Akulevich NM, Ratanajaraya C, Mitsutake N, Takamura N, Danilova LI, Lushchik ML, Demidchik YE, Heath S, Yamada R, Lathrop M, Matsuda F, Yamashita S
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Journal Title
Hum Mol Genet
Volume: 19(12)
Pages: 2516-23
NAID
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[Journal Article] Leptin : high molecular weight adiponectin ratio is independently correlated with carotid intima-media thickness in men, but not in women2010
Author(s)
Takamura N, Hayashida N, Hagane K, Kadota K, Yamasaki H, Abiru N, Ozono Y, Kamihira S, Ishibashi K, Nakazato M, Maeda T
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Journal Title
Biomarkers
Volume: 15(4)
Pages: 340-4
NAID
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[Journal Article] A validated HPLC-fluorescence method with a semi-micro column for routine determination of homocysteine, cysteine and cysteamine, and the relation between the thiol derivatives in normal human plasma2009
Author(s)
Ichinose S, Nakamura M, Maeda M, Ikeda R, Wada M, Nakazato M, Ohba Y, Takamura N, Maeda T, Aoyagi K, Nakashima K
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Journal Title
Biomed Chromatogr
Volume: 23(9)
Pages: 935-9
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