A cohort study on the effect of vitamin D on fracture and bone mineral density as outcomes of osteoporosis

• Project/Area Number: 21590722
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Public health/Health science
• Research Institution: Niigata University of Health and Welfare
• Principal Investigator: SAITO Toshiko 新潟医療福祉大学, 健康科学部, 教授 (40339958)
• Co-Investigator(Kenkyū-buntansha): NAKAMURA Kazutoshi 新潟大学, 医歯学系, 教授 (70207869)
• Project Period (FY): 2009 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2011: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000); Fiscal Year 2010: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000); Fiscal Year 2009: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
• Keywords: 保健栄養 / 疫学 / 骨粗鬆症 / 骨折 / コホート研究 / ビタミンD / 女性 / 予防医学 / 栄養 / カットオフ値

Research Abstract

The aim of this study was to determine preventive effects of vitamin D on bone parameters in relation to osteoporosis. A five-year and six-year cohort studies were conducted in Yokogoshi and Muramatsu, respectively. Subjects were 595 women aged between 55 and 74 years in Yokogoshi and 775 women aged 70 years and over in Muramatsu. Serum 25-hydroxyvitamin D(25[OH] D) at baseline was measured as an index of vitamin D status, and outcomes were bone mineral density(BMD) and incident osteoporotic fractures, respectively. Although 25(OH) D was not associated a five-year change in BMD of hip or lumbar spine, the high 25(OH) D(≧71 nmol/L) associated with lower risk of fracture.

Research Products

• [Journal Article] sufficiency is associated with low incidence of limb and vertebral fractures in community-dwelling elderly Japanese women : the Muramatsu Study (2011)
  • Author(s): Nakamura K, Saito T, Oyama M, Oshiki R, Kobayashi R, Nishiwaki T, Nashimoto M, Tsuchiya Y. Vitamin D
  • Journal Title: Osteoporos Int Volume: 22 Pages: 97-103
• [Journal Article] Vitamin D sufficiency is associated with low incidence of limb and vertebral fractures in community-dwelling elderly Japanese women : the Muramatsu Study
  • Author(s): Nakamura K, Saito T, 他6名
  • Journal Title: Osteoporosis International (印刷中)
  • Peer Reviewed
• [Presentation] sufficiency is associated with low incidence of limb and vertebral fractures in community-dwelling elderly Japanese women : the Muramatsu Study (2010)
  • Author(s): Nakamura K, Saito T, Oyama M, Oshiki R, Kobayashi R. Vitamin D
  • Organizer: IOF World Congress on Osteoporosis & Tenth European Congress on Clinical and Economic Aspects of Osteoporosis and Osteoarthritis
  • Place of Presentation: Florence, Italy