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A comparative study of the relationship between morbidity and disability among exceptional survivors in Okinawa, Hawaii and mainland USA

Research Project

Project/Area Number 21590724
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Public health/Health science
Research InstitutionOkinawa International University

Principal Investigator

WILLCOX Donald Craig  沖縄国際大学, 総合文化学部, 教授 (70316214)

Research Collaborator 鈴木 信  琉球大学, 医学部, 名誉教授
ウィルコックス ブラッドリー  Pacific Health Research Institute, 研究員
矢野 勝彦  Pacific Health Research Institute, 研究員
カーブ デビッド  Pacific Health Research Institute, 研究所長
パールズ トム  ボストン大学, 医学部, 准教授・NECSディレクター
Project Period (FY) 2009 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywords沖縄 / 長寿 / 百寿者 / 日常生活動作 / 既往歴 / 健康長寿 / 国際比較 / 自立度
Research Abstract

This project compared the relationship between morbidity and disability among centenarians in three areas: Okinawa (OCS), Hawaii (HHP) and mainland USA (NECS). Findings indicated: 1) about 1/3 of centenarians were classified as "survivors" (age of disease onset before age of 85 years) with higher numbers found in the HHP cohort, mainly due to relatively early onset of diabetes and hypertension in HHP men. 2) The greatest ADL difficulties among participants were found in "walking" and "hearing", however most remained independent in "self-feeding". 3) Men had fewer ADL difficulties than women. 4) Dementia, cerebrovascular disease and cataracts showed the strongest relationship with ADL difficulties.

Report

(4 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • 2009 Annual Research Report
  • Research Products

    (64 results)

All 2012 2011 2010 2009 Other

All Journal Article (17 results) (of which Peer Reviewed: 16 results) Presentation (31 results) Book (5 results) Remarks (11 results)

  • [Journal Article] The Gender gap in health-span and life expectancy in Okinawa: a focus health behaviors2012

    • Author(s)
      Willcox DC, Willcox BJ, Yasura S, Ashitomi I, Suzuki M
    • Journal Title

      Asian J Gerontol Geriatr

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] FOXO3 gene variants and human aging: coding variants may not be key players2012

    • Author(s)
      Donlon TA, Curb JD, He Q, Grove JS, Masaki K, Rodriguez B, Elliot A, Willcox DC, Willcox BJ
    • Journal Title

      J Gerontol A Biol Sci Med Sci

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Extending healthy aging: nutrient sensing pathway and centenarian population2012

    • Author(s)
      Davinelli S, Willcox DC, Scapagnini G
    • Journal Title

      Immun Ageing

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] A brief exploration of the gender gap in healthspan and life expectancy in Okinawa : a focus on health behaviors2012

    • Author(s)
      Willcox DC, Willcox BJ, Yasura S, Ashitomi I, Suzuki M
    • Journal Title

      Asian Journal of Gerontology and Geriatrics

      Volume: (In press)

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] FOXO3 gene variants and human aging : coding variants may not be key players2012

    • Author(s)
      Donlon TA, Curb JD, He Q, Grove JS, Masaki K, Rodriguez B、Elliot A, Willcox DC, Willcox BJ
    • Journal Title

      Journal of Gerontology : Biological and Medical Sciences

      Volume: 67 Issue: 11 Pages: 1132-1139

    • DOI

      10.1093/gerona/gls067

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Extending healthy aging : nutrient sensing pathway and centenarian population2012

    • Author(s)
      Davinelli S, Willcox DC, Scapagnini G
    • Journal Title

      Immunity and Ageing

      Volume: 9 Issue: 1

    • DOI

      10.1186/1742-4933-9-9

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 超高齢者における要介護状態・健康障害の増加傾向~新たな虚弱年齢層出現の兆し~2011

    • Author(s)
      Willcox DC, Suzuki M, Ashitomi I, Willcox BJ
    • Journal Title

      人間福祉研究

      Volume: 第8巻 Pages: 1-21

    • Related Report
      2011 Final Research Report 2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Are men aging as oaks and women as reeds? A behavioral hypothesis to explain the gender paradox of French centenarians2011

    • Author(s)
      Balard F, Beluche I, Romieu I, Willcox DC, Robine JM
    • Journal Title

      J Aging Res

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Are men aging as oaks and women as reeds? A behavioral hypothesis to explain the gender paradox of French centenarians2011

    • Author(s)
      Balard F, Beluche I, Romieu I, Willcox DC, Robine JM
    • Journal Title

      Journal of Aging Research

      Volume: 2011 Pages: 1-12

    • DOI

      10.4061/2011/371039

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Oxidative stress and longevity in Okinawa: an investigation of blood lipid peroxidation and tocopherol in Okinawan centenarians2010

    • Author(s)
      Suzuki M, Willcox DC, Rosenbaum MW, Willcox BJ
    • Journal Title

      Curr Gerontol Geriatr Res

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Physical aspects of healthy aging: assessments of three measures of balance for studies in middle-aged and older adults2010

    • Author(s)
      Ceria-Ulep CD, Grove J, Chen R, Masaki KH, Rodriguez BL, Donlon TA, Guralnik J, Willcox BJ, Willcox DC, Nigg C, Curb JD
    • Journal Title

      Curr Gerontol Geriatr Res

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Centenarians: How their studies contribute to our understanding of the aging process and longevity2010

    • Author(s)
      Willcox D, Willcox B, Poon L.(Editorial)
    • Journal Title

      Curr Gerontol Geriatr Res

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Oxidative stress and longevity in Okinawa : an investigation of blood lipid peroxidation and tocopherol in Okinawan centenarians2010

    • Author(s)
      Suzuki M, Willcox DC, Rosenbaum MW, Willcox BJ.
    • Journal Title

      Curr Gerontol Geriatr Res.

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Physical aspects of healthy aging : assessments of three measures of balance for studies in middle-aged and older adults2010

    • Author(s)
      Ceria-Ulep CD, Grove J, Chen R, Masaki KH, Rodriguez BL, Donlon TA, Guralnik J, Willcox BJ, Willcox DC, Nigg C, Curb JD
    • Journal Title

      Curr Gerontol Geriatr Res.

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Centenarians : How their studies contribute to our understanding of the aging process and longevity2010

    • Author(s)
      Willcox D, Willcox B, Poon L.
    • Journal Title

      Curr Gerontol Geriatr Res.

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Risky business, life expectancy and the gender gap in Okinawa: Why women are on top and men in middle2009

    • Author(s)
      Willcox DC
    • Journal Title

      沖縄女性研究者の会

      Volume: (6)2 Pages: 21-35

    • Related Report
      2011 Final Research Report
  • [Journal Article] Risky business, life expectancy and the gender gap in Okinawa : Why women are on top and men in middle.2009

    • Author(s)
      Willcox DC
    • Journal Title

      沖縄女性研究者の会 6

      Pages: 21-35

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Presentation] International comparative studies of healthy aging in Japan, Hawaii and the U.S. mainland2012

    • Author(s)
      Willcox BJ, Suzuki M, Curb JD, Willcox DC
    • Organizer
      日本総合検診医学会
    • Place of Presentation
      東京
    • Related Report
      2011 Final Research Report
  • [Presentation] Can the Okinawa diet prevent prostate cancer?2012

    • Author(s)
      Willcox DC, Willcox BJ
    • Organizer
      Teikyo University, Faculty of Medicine and Takeda Pharmaceutical Company
    • Place of Presentation
      東京
    • Related Report
      2011 Annual Research Report
  • [Presentation] International comparative studies of healthy aging in Japan, Hawaii and the U.S.mainland2012

    • Author(s)
      Willcox BJ, Suzuki M, Curb JD, Willcox DC
    • Organizer
      日本総合検診医学会
    • Place of Presentation
      東京
    • Related Report
      2011 Annual Research Report
  • [Presentation] The biodemography of supercentenarians in Okinawa: An update from the field2011

    • Author(s)
      Willcox DC, Willcox BJ, Suzuki M
    • Organizer
      8th Supercentenarian Workshop
    • Place of Presentation
      Madrid, Spain
    • Related Report
      2011 Final Research Report
  • [Presentation] Gender and longevity based on experiences in the Blue Zones2011

    • Author(s)
      Willcox DC, Willcox BJ, Suzuki M
    • Organizer
      International Conference on Healthy Longevity: The Emergence of Oldest-old and Centenarians
    • Place of Presentation
      Hong Kong
    • Related Report
      2011 Final Research Report
  • [Presentation] Nutrition and healthy aging in Okinawa: energy balance, dietary factors, and exceptional longevity2011

    • Author(s)
      Willcox DC, Willcox BJ, He Q, Suzuki M, Chen R, Curb DJ, Curb JD
    • Organizer
      Gerontological Society of America
    • Place of Presentation
      Boston
    • Related Report
      2011 Final Research Report
  • [Presentation] Nutrition and longevity in the Kuakini Hawaii Lifespan Study: diet, genes and energy sensing pathways2011

    • Author(s)
      Bell C, Curb DJ, Masaki K, He Q, Donlon T, Willcox DC, Willcox BJ
    • Organizer
      Gerontological Society of America
    • Place of Presentation
      Boston
    • Related Report
      2011 Final Research Report
  • [Presentation] Healthy aging2011

    • Author(s)
      Willcox DC, Willcox BJ
    • Organizer
      PA International and Asian Population and Development Association
    • Place of Presentation
      東京
    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Presentation] Can the Okinawa diet prevent prostate cancer?2011

    • Author(s)
      Willcox DC, Willcox BJ
    • Organizer
      帝京大学, 医学部
    • Place of Presentation
      東京
    • Related Report
      2011 Final Research Report
  • [Presentation] Gender and longevity based on experiences in the Blue Zones2011

    • Author(s)
      Willcox DC, Willcox BJ, Suzuki M
    • Organizer
      International Conference on Healthy Longevity : The Emergence of Oldest-old and Centenarians
    • Place of Presentation
      香港
    • Related Report
      2011 Annual Research Report
  • [Presentation] Nutrition and healthy aging in Okinawa : energy balance, dietary factors, and exceptional longevity2011

    • Author(s)
      Willcox DC、Willcox BJ, He Q, Suzuki M, Chen R, Curb DJ
    • Organizer
      Gerontological Society of America
    • Place of Presentation
      アメリカ・ボストン
    • Related Report
      2011 Annual Research Report
  • [Presentation] Nutrition and longevity in the Kuakini Hawaii Lifespan Study : diet, genes and energy sensing pathways2011

    • Author(s)
      Bell C, Curb DJ, Masaki K, He Q, Donlon T, Willcox DC, Willcox BJ
    • Organizer
      Gerontological Society of America
    • Place of Presentation
      アメリカ・ボストン
    • Related Report
      2011 Annual Research Report
  • [Presentation] The biodemography of supercentenarians in Okinawa : An update from the field2011

    • Author(s)
      Willcox DC, Willcox BJ, Suzuki M.
    • Organizer
      8th Supercentenarian Workshop
    • Place of Presentation
      スペイン・マドリッド
    • Related Report
      2010 Annual Research Report
  • [Presentation] Cross-National Perspectives on Health Aging: Insights from the Study of the Oldest Old in Okinawa and Hawaii2010

    • Author(s)
      Willcox DC, Willcox BJ, Suzuki M, Curb JD
    • Organizer
      FUTURAGE;EU Road Map for Ageing Research
    • Place of Presentation
      Newcastle, UK
    • Related Report
      2011 Final Research Report
  • [Presentation] Okinawa Centenarian Study and Georgia Centenarian Study Collaboration2010

    • Author(s)
      Willcox DC, Willcox BJ, Suzuki M
    • Organizer
      Brass Town Valley Workshop
    • Place of Presentation
      University of Georgia, Atlanta
    • Related Report
      2011 Final Research Report
  • [Presentation] Japan Centenarian Studies Collaboration2010

    • Author(s)
      Willcox DC, Willcox BJ, Suzuki M
    • Organizer
      Nihon University Centenarian Study Meeting: Japan Group
    • Place of Presentation
      東京
    • Related Report
      2011 Final Research Report
  • [Presentation] Cross-National perspectives on healthy aging: Insights from the study of the oldest old in Okinawa and Hawaii II2010

    • Author(s)
      Willcox DC, Willcox BJ, Suzuki M, Curb JD.
    • Organizer
      FUTURAGE; EU Road Map for Aging Research
    • Place of Presentation
      Newcastle, UK
    • Related Report
      2011 Final Research Report
  • [Presentation] Update from Okinawa Centenarian Study for 5 COOP Study2010

    • Author(s)
      Willcox DC, Willcox BJ, Suzuki M
    • Organizer
      National Institute on Health and Medical Research (INSERM)
    • Place of Presentation
      Archamps, France
    • Related Report
      2011 Final Research Report
  • [Presentation] Biological secrets to healthy aging2010

    • Author(s)
      Willcox DC, Willcox BJ, Suzuki M
    • Organizer
      Gerontological Society of America
    • Place of Presentation
      New Orleans
    • Related Report
      2011 Final Research Report
  • [Presentation] Surviving a century of transitions: The adaptational strategies of a 104 year old male expert survivor2010

    • Author(s)
      Willcox DC, Willcox BJ, Suzuki M
    • Organizer
      Gerontological Society of America
    • Place of Presentation
      New Orleans
    • Related Report
      2011 Final Research Report
  • [Presentation] Okinawa Centenarian Study and Georgia Centenarian Study Collaboration2010

    • Author(s)
      Willcox DC, Willcox BJ, Suzuki M.
    • Organizer
      Brass Town Valley Workshop, University of Georgia
    • Place of Presentation
      アメリカアトランタ
    • Related Report
      2010 Annual Research Report
  • [Presentation] Japan Centenarian Studies Collaboration2010

    • Author(s)
      Willcox DC, Willcox BJ, Suzuki M.
    • Organizer
      Nihon University International Centenarian Study Meeting : Japan Group
    • Place of Presentation
      東京、日本大学
    • Related Report
      2010 Annual Research Report
  • [Presentation] Cross-National perspectives on healthy aging : Insights from the study of the oldest old in Okinawa and Hawaii II2010

    • Author(s)
      Willcox DC, Willcox BJ, Suzuki M, Curb JD.
    • Organizer
      FUTURAGE ; EU Road Map for Aging Research
    • Place of Presentation
      イギリス・ニューキャッスル
    • Related Report
      2010 Annual Research Report
  • [Presentation] Update from Okinawa Centenarian Study for 5 Co-op Study2010

    • Author(s)
      Willcox DC, Willcox BJ, Suzuki M.
    • Organizer
      National Institute on Health and Medical Research (INSERM)
    • Place of Presentation
      フランス・アーチアンプス
    • Related Report
      2010 Annual Research Report
  • [Presentation] Biological secrets to healthy aging2010

    • Author(s)
      Willcox DC, Willcox BJ, Suzuki M.
    • Organizer
      Gerontological Society of America
    • Place of Presentation
      アメリカ・ニューオリンズ
    • Related Report
      2010 Annual Research Report
  • [Presentation] Surviving a century of transitions : The adaptational strategies of a 104 year old male expert survivor2010

    • Author(s)
      Willcox DC, Willcox BJ, Suzuki M.
    • Organizer
      Gerontological Society of America
    • Place of Presentation
      アメリカ・ニューオリンズ
    • Related Report
      2010 Annual Research Report
  • [Presentation] Cross-National Perspectives on Health Aging : Insights from the Study of the Oldest Old in Okinawa and Hawaii2010

    • Author(s)
      Willcox DC, Willcox BJ, Suzuki M, Curb JD
    • Organizer
      FUTURAGE ; EU Road Map for Ageing Research
    • Place of Presentation
      イギリス(ニューキャッスル)
    • Related Report
      2009 Annual Research Report
  • [Presentation] Phenotypical characteristics of super-centenarians in Okinawa, Japan2009

    • Author(s)
      Willcox DC, Willcox BJ, Wang N-C, He Q, Rosenbaum M, Suzuki M
    • Organizer
      World Congress of Gerontology
    • Place of Presentation
      Paris
    • Related Report
      2011 Final Research Report
  • [Presentation] The Okinawa diet: A nutritional approach to modulating "inflammaging"2009

    • Author(s)
      Willcox DC, Willcox BJ, Todoriki H, Suzuki M
    • Organizer
      9th World Congress on Inflammation
    • Place of Presentation
      東京
    • Related Report
      2011 Final Research Report
  • [Presentation] Phenotypical characteristics of super-centenarians in Okinawa, Japan.2009

    • Author(s)
      Willcox BJ, Willcox DC, Wang N-C, He Q, Rosenbaum M, Suzuki M
    • Organizer
      World Congress of Gerontology 2009
    • Place of Presentation
      フランス(パリ)
    • Related Report
      2009 Annual Research Report
  • [Presentation] The Okinawa diet : A nutritional approach to modulating "inflammaging"2009

    • Author(s)
      Willcox DC, Willcox BJ, Todoriki H, Suzuki M
    • Organizer
      9th World Congress on Inflammation
    • Place of Presentation
      東京
    • Related Report
      2009 Annual Research Report
  • [Book] The Okinawa Program. Thai translation2011

    • Author(s)
      Willcox BJ,Willcox DC, Suzuki M
    • Total Pages
      550
    • Publisher
      SE-Education Public Company Limited
    • Related Report
      2011 Final Research Report
  • [Book] Okinawa: a naturally calorie restricted population; In Everitt AV et al. (Eds): Calorie Restriction, Aging and Longevity2010

    • Author(s)
      Rosenbaum MW, Willcox BJ, Willcox DC, Suzuki M
    • Publisher
      Springer
    • Related Report
      2011 Final Research Report
  • [Book] The Okinawa Diet Plan. Chinese translation2010

    • Author(s)
      Willcox BJ,Willcox DC, Suzuki M
    • Total Pages
      381
    • Publisher
      南海出版公司
    • Related Report
      2011 Final Research Report
  • [Book] Calorie Restriction, Aging and Longevity2010

    • Author(s)
      Rosenbaum MW, Willcox BJ, Willcox DC, Suzuki M.
    • Publisher
      Springer Science
    • Related Report
      2010 Annual Research Report
  • [Book] Exceptional Longevity and the Quest for Healthy Aging: Insights from the Okinawa Centenarian In: Sokolovsky J. (Ed.). The Cultural Context of Aging:Worldwide Perspectives2009

    • Author(s)
      Willcox DC, Willcox BJ, Rosenbaum M, Sokolovsky J, Suzuki M
    • Publisher
      Praeger
    • Related Report
      2011 Final Research Report
  • [Remarks] New Scientist. Secrets of the Centenarians: Life Begins at 100. 2009.09.07. (雑誌)

    • Related Report
      2011 Final Research Report
  • [Remarks] Nova Science Now. Can we Slow Human Aging? 2011.02.26. (テレビ)

    • Related Report
      2011 Final Research Report
  • [Remarks] Variance Films. How to Live Forever. 2011.05.13. (ドキュメンタリーフィルム)

    • Related Report
      2011 Final Research Report
  • [Remarks] ADAMIS Productions. Le Mystere des Centenaires. 2011.06.12. (ドキュメンタリーフィルム)

    • Related Report
      2011 Final Research Report
  • [Remarks] Dan Rather Reports (HD Net). Oldsters of Okinawa. 2012.02.14. (テレビ)

    • Related Report
      2011 Final Research Report
  • [Remarks] Russia-2 Channel. Forever Young. 2012.02.19. (テレビ)

    • Related Report
      2011 Final Research Report
  • [Remarks] Arnold Center for Confluent Media Studies. University of Miami. The Silver Mirror. 2012.03.24. (ドキュメンタリーフィルム)

    • Related Report
      2011 Final Research Report
  • [Remarks] The Huffington Post. The Luck in Longevity. 2012.07.17. (オンライン新聞)

    • Related Report
      2011 Final Research Report
  • [Remarks] Okinawa Centenarian Study website access at

    • Related Report
      2011 Final Research Report
  • [Remarks]

    • URL

      http://www.okicent.org/

    • Related Report
      2011 Annual Research Report
  • [Remarks]

    • URL

      http://www.okicent.org/

    • Related Report
      2010 Annual Research Report

URL: 

Published: 2009-04-01   Modified: 2016-04-21  

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