| Project/Area Number |
21590736
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Legal medicine
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| Research Institution | Shimane University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
TAKESHITA Haruo 島根大学, 医学部, 教授 (90292599)
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| Project Period (FY) |
2009 – 2011
|
| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2009: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 亜ヒ酸 / 遺伝的多型 / 感受性 / メチル化 / APL / 酸化 / AS3MT / 遺伝的多型形質 / 治療 |
|---|
| Research Abstract |
The concentrations of arsenic compounds(dimethylarsinic acid(DMA), monomethylarsonic acid(MMA), As(V), and As(III)) and 8-hydroxy-2'-deoxyguanosine(8-OHdG) in the urine of an acute promyelocytic leukemia(APL) patient during Arsenic trioxide treatment were determined. In adult patient, the methylated arsenic(DMA and MMA) concentrations were increased during the consolidation therapy. Significant positive correlations were observed between concentrations of 8-OHdG and DMA, between concentrations of 8-OHdG and MMA, and between concentrations of 8-OHdG and the sum of arsenic compounds. In pediatric patient, the levels of arsenic compounds and urinary arsenic level and% of MMA and DMA were lower than those of adult patient and significant positive correlations were observed between concentrations of 8-OHdG and DMA.
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