Study on gene related to arsenic susceptibility in patient treated with arsenic trioxide
Project/Area Number |
21590736
|
Research Category |
Grant-in-Aid for Scientific Research (C)
|
Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Legal medicine
|
Research Institution | Shimane University |
Principal Investigator |
|
Co-Investigator(Kenkyū-buntansha) |
TAKESHITA Haruo 島根大学, 医学部, 教授 (90292599)
|
Project Period (FY) |
2009 – 2011
|
Project Status |
Completed (Fiscal Year 2011)
|
Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2009: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
|
Keywords | 亜ヒ酸 / 遺伝的多型 / 感受性 / メチル化 / APL / 酸化 / AS3MT / 遺伝的多型形質 / 治療 |
Research Abstract |
The concentrations of arsenic compounds(dimethylarsinic acid(DMA), monomethylarsonic acid(MMA), As(V), and As(III)) and 8-hydroxy-2'-deoxyguanosine(8-OHdG) in the urine of an acute promyelocytic leukemia(APL) patient during Arsenic trioxide treatment were determined. In adult patient, the methylated arsenic(DMA and MMA) concentrations were increased during the consolidation therapy. Significant positive correlations were observed between concentrations of 8-OHdG and DMA, between concentrations of 8-OHdG and MMA, and between concentrations of 8-OHdG and the sum of arsenic compounds. In pediatric patient, the levels of arsenic compounds and urinary arsenic level and% of MMA and DMA were lower than those of adult patient and significant positive correlations were observed between concentrations of 8-OHdG and DMA.
|
Report
(4 results)
Research Products
(76 results)
-
-
-
[Journal Article] Functional and genetic survey of all known the SNPs within human deoxyribonuclease I gene in wide-ranging ethnic groups2011
Author(s)
Fujihara J, Ueki M, Yasuda T, Iida R, Soejima M, Koda Y, Kimura-Kataoka K,Kato H, Panduro A, Tongu M, Takeshita H
-
Journal Title
DNA and Cell Biol.
Volume: 30(4)
Issue: 4
Pages: 205-217
DOI
Related Report
Peer Reviewed
-
-
-
[Journal Article] Identification of the brackish water clam Corbicula japonica (Japanese name, Yamato-shijimi) and pecification of the growing district by PCR-based analysis of mitochondrial DNA2011
Author(s)
Fujihara, J, Yasuda, T, Ueki M, Fujita Y, Nakamura M, Oshiumi C, Hosozawa T, Nabika T, Harada Y, Kobayashi T, Nakajima T, Takeshita H
-
Journal Title
Environmental Forensics Journal
Volume: 9
Issue: 2
Pages: 25-31
DOI
Related Report
Peer Reviewed
-
[Journal Article] Confirmation that SNPs in the high mobility group-A2 gene (HMGA2) are associated with adult height in the Japanese population ; wide-ranging population survey of height-related SNPs in HMGA22011
Author(s)
Takeshita H, Fujihara J, Soejima M, Koda Y, Kimura-Kataoka K, Ono R, Yuasa I, Iida R, Ueki M, Nagao M, Yasuda T
-
Journal Title
Electrophoresis
Volume: 32
Issue: 14
Pages: 1844-1851
DOI
Related Report
Peer Reviewed
-
-
-
-
-
-
[Journal Article] A biochemical and genetic study on all non-synonymous single nucleotide polymorphisms of the gene encoding human deoxyribonuclease I potentially relevant to autoimmunity.2010
Author(s)
Yasuda T, Ueki M, Takeshita H, Fujihara J, Kimura-Kataoka K, Iida R, Tsubota E, Soejima M, Koda Y, Kato H, Panduro A.
-
Journal Title
Int J Biochem Cell Biol.
Volume: 42
Pages: 1216-1225
Related Report
Peer Reviewed
-
-
-
-
[Journal Article] Exposure, metabolism, and health effects of arsenic in residents from arsenic-contaminated groundwater areas of Vietnam and Cambodia : a review.2010
Author(s)
Agusa T, Kunito T, Kubota R, Inoue S, Fujihara J, Minh TB, Ha NN, Tu NP, Trang PT, Chamnan C, Takeshita H, Iwata H, Tuyen BC, Viet PH, Tana TS, Tanabe S.
-
Journal Title
Rev Environ Health
Volume: 25
Pages: 193-220
Related Report
Peer Reviewed
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
[Journal Article] Caucasian-specific allele in non-synonymous single nucleotide polymorphisms of the gene encoding deoxyribonuclease I-like 3, potentially relevant to autoimmunity, produces an inactive enzyme.2009
Author(s)
Ueki M, Takeshita H, Fujihara J, Iida R, Yuasa I, Kato H, Panduro A, Nakajima T, Kominato Y, Yasuda T.
-
Journal Title
Clin Chim Acta. 407
Pages: 20-24
Related Report
Peer Reviewed
-
-
-
[Journal Article] 核酸分解酵素DNase I 遺伝子の転写調節機構の解明.2009
Author(s)
高木利恵, 中島たみ子, 小湊慶彦, 加藤恵理子, 高士祐一, 新田みなみ, 山根庸弘, 藤原純子, 竹下治男, 植木美鈴, 安田年博.
-
Journal Title
NAID
Related Report
Peer Reviewed
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-