| Project/Area Number |
21590741
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Legal medicine
|
|---|
| Research Institution | Wakayama Medical University |
|---|
Principal Investigator |
NOSAKA Mizuho 和歌山県立医科大学, 医学部, 助教 (00244731)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
KONDO Toshikazu 和歌山県立医科大学, 医学部, 教授 (70251923)
KIMURA Akihiko 和歌山県立医科大学, 医学部, 准教授 (60136611)
ISHIDA Yuko 和歌山県立医科大学, 医学部, 講師 (10364077)
|
|---|
| Project Period (FY) |
2009 – 2011
|
| Project Status |
Completed (Fiscal Year 2011)
|
| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2009: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
|
|---|
| Keywords | 法医病理学 / 深部静脈血栓塞栓症 / 血栓陳旧度 / uPA / tPA / PAI-1 / TNF-α / TNF-Rp55 / MMP-2 / MMP-9 / VEGF / 新生血管 / IFN-γ / 好中球 / マクロファージ / myofibroblast / INF-γ |
|---|
| Research Abstract |
The histopathological and immunohistochemical examinations were performed on venous thrombi, which developed in the ligation of the inferior vena cava to obtain the index of the thrombus age determination. For example, the ratio of neutrophils and macrophages, appearance of neovessels and the harmonization of uPA, tPA and PAI-1 on the thrombi were useful indices for thrombus age determination. Furthermore, we found that IFN-γmay be a novel molecular target to prevent intravenous thrombus development in patients with high risk factors.
|
