| Project/Area Number |
21590744
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Legal medicine
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| Research Institution | Showa University |
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Principal Investigator |
SATO Keizo 昭和大学, 医学部, 教授 (20162422)
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| Co-Investigator(Kenkyū-buntansha) |
LEE Xiao-peng 昭和大学, 医学部, 講師 (90245829)
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| Co-Investigator(Renkei-kenkyūsha) |
SUZUKI Shinichi 昭和大学, 医学部, 客員教授 (00356198)
FUJISHIRO Masaya 昭和大学, 医学部, ポストドクター (00527161)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2011: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2010: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2009: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
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| Keywords | フェンタニル・デザイナードラッグ・GC / GC/MS・HPLC / HPLC/MS・ミクロ固相抽出・フェノチアジン / フェンタニル / デザイナー・ドラッグ / GC,GC/MS / HPLC,HPLC/MS / ミクロ固相抽出 / フェノチアジン / GC/MS / α-メテルフェンタニル / 微量代謝物 / GC,GC / MS / α-メチルフェンタニル |
|---|
| Research Abstract |
In order to prove narcotic abuse, detection and identification of its metabolites, which reflect peculiar chemical structure of the narcotic, in urine obtained from an abuser of the drug is essential. Though α-methylfentanyl is the representative designer drug of the fentanyl and its related compounds, major metabolites of the narcotic do not reflect peculiar chemical structure of the drug. In this study, we were able to detect and identify four minor metabolites, which reflect peculiar chemical structure of the α-methylfentanyl in urine obtained from rats to which we gave the narcotic orally. In addition, we could develop not only the method for solid-phase microextraction of the α-methylfentanyl from urine or blood but also that for quantitation of the drug in urine or blood with gas chromatography(GC)/mass spectrometry(MS).
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