| Project/Area Number |
21590746
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Legal medicine
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| Research Institution | Tokai University |
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Principal Investigator |
OSAWA Motoki 東海大学, 医学部, 教授 (90213686)
|
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| Co-Investigator(Kenkyū-buntansha) |
KIMURA Ryousuke 琉球大学, 亜熱帯島嶼科学超域研究推進機構, 特命准教授 (00453712)
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| Co-Investigator(Renkei-kenkyūsha) |
INAOKA Yoshihiko 東海大学, 医学部, 助教 (50564689)
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| Project Period (FY) |
2009 – 2011
|
| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2011: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2009: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | 親子鑑定 / DNA多型 / SNP / マイクロアレイ / 遺伝子 |
|---|
| Research Abstract |
The multiplex system of 15 STR loci has been employed in kinship analysis, but its power is insufficient even for sibship. The microarray technique allows us to obtain massive SNP genotype data. As indices for the evaluation based on SNP, the proportion of identical-by-decent(IBD) numbers was preferable, in which linkage disequilibrium and minor allele frequency were conditioned. The minimum number to separate kinship from unrelated pairs was estimated to be approximately 500 and several thousands of SNPs for siblings and the second degree, respectively.
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