| Project/Area Number |
21590747
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Legal medicine
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| Research Institution | Tokyo Medical University |
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Principal Investigator |
HARA Shuichi 東京医科大学, 医学部, 准教授 (70208651)
|
|---|
| Co-Investigator(Renkei-kenkyūsha) |
KURIIWA Fumi 東京医科大学, 医学部, 助手 (30468665)
|
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| Research Collaborator |
MIZUKAMI Hajime 東京医科大学, 医学部, 准教授
MUKAI Toshiji 聖マリアンナ医科大学, 医学部, 教授
KOBAYASHI Masamune 東京医科大学, 医学部, 助教
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2009: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 一酸化炭素中毒 / 脳 / 酸化ストレス / ヒドロキシルラジカル / cAMP / protein kinase A(PKA) / exchange protein directly activated by cAMP(Epac) / 一酸化炭素 / プリン受容体 / ラット線条体 / dibutyryl-cAMP / 8-bromo-cAMP / forskolin / H7 / H89 / ラット / 線条体 |
|---|
| Research Abstract |
Oxidative stress(production of hydroxyl radicals, the most toxic reactive oxygen species) was enhanced in the brain during severe carbon monoxide(CO) poisoning with 70% CO-hemoglobin in blood, but not moderate CO poisoning with 50% CO-hemoglobin in blood. The present results suggest that the enhancement of oxidative stress might be due to CO itself, but not hypoxia induced by CO poisoning, and mediated through activation of intracellular cAMP signaling pathways via purine P2Y11-like receptors.
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