Analysis of polymorphisms and association study of FUT2 and FUT3, regulating synthesis of Lewis blood group antigens.
Project/Area Number |
21590750
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Legal medicine
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Research Institution | Kurume University |
Principal Investigator |
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Co-Investigator(Kenkyū-buntansha) |
KODA Yoshiro 久留米大学, 医学部, 教授 (90231307)
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Project Period (FY) |
2009 – 2011
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Project Status |
Completed (Fiscal Year 2011)
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Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2009: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
|
Keywords | 糖転移酵素 / 糖鎖 / 血液型 / 遺伝子多型 / ルイス式血液型 / 分泌型 / DNA多型 / 遺伝子組換え / DNAメチル化 |
Research Abstract |
The FUT2 and FUT3 regulate the synthesis of the ABO and Lewis blood group antigens. Recent studies have shown these genes were rich in polymorphisms with population-specific manner. We developed new methods to determine not only SNPs but copy number variations of the FUT2 to promote such studies. In addition, we performed analysis of the transcriptional region of the FUT2 and association study of polymorphisms and lifestyle-related diseases.
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Report
(4 results)
Research Products
(54 results)
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[Journal Article] Nonsynonymous Single-Nucleotide Polymorphisms of the Human Apoptosis-Related Endonuclease-DNA Fragmentation Factor Beta Polypeptide, Endonuclease G, and Flap Endonuclease-1-Genes Show a Low Degree of Genetic Heteroseneity2012
Author(s)
Takeshita H, Fujihara J, Ueki M, Iida R, Koda Y, Soejima M, Yuasa I, Kato H, Nakajima T, Kominato Y, Yasuda T
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Journal Title
DNA Cell Biol
Volume: 1
Pages: 36-42
Related Report
Peer Reviewed
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[Journal Article] Confirmation that SNPs in the high mobility group-A2 gene (HMGA2) are associated with adult height in the Japanese population ; wide-ranging population survey of height-related SNPs in HMGA22011
Author(s)
Takeshita H, Fujihara J, Soejima M, Koda Y, Kimura-Kataoka K, Ono R, Yuasa I, Iida R, Ueki M, Nagao M, Yasuda T
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Journal Title
Electrophoresis
Volume: 32
Issue: 14
Pages: 1844-1851
DOI
Related Report
Peer Reviewed
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[Journal Article] Functional and gcnctic surycy of all known single-nucleotide polymuphisms within the human deoxyribonuclease I gene in wide-ranging ethnic groups2011
Author(s)
Fujihara J, Ueki M, Yasuda T, Iida R, Soejima M, Koda Y, Kimura-Kataoka K, Kato H, Panduro A, Tongu M, Takeshita H
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Journal Title
DNA Cell Biol
Volume: 30
Pages: 205-217
Related Report
Peer Reviewed
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[Journal Article] Functional and genetic survey of all known single-nucleotide polymorphisms within the human deoxyribonuclease I gene in wide-ranging ethnic groups.2011
Author(s)
Fujihara J, Ueki M, Yasuda T, Iida R, Soejima M, Koda Y, Kimura-Kataoka K, Kato H, Panduro A, Tongu M, Takeshita H.
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Journal Title
DNA Cell Biol.
Volume: 30(In press)
Related Report
Peer Reviewed
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[Journal Article] A biochemical and genetic study on all non-synonymous single nucleotide polymorphisms of the gene encoding human deoxyribonuclease I potentially relevant to autoimmunity.2010
Author(s)
Yasuda T, Ueki M, Takeshita H, Fujihara J, Kimura-Kataoka K, Iida R, Tsubota E, Soejima M, Koda Y, Kato H, Panduro A.
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Journal Title
Int J Biochem CellBiol.
Volume: 42
Pages: 1216-1225
Related Report
Peer Reviewed
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[Presentation] FOXP2を用いた人獣鑑別法2011
Author(s)
副島美貴子, 廣重憲一, 吉本譲爾, 神田芳郎
Organizer
日本DNA多型学会第20回学術集会
Place of Presentation
はまぎんホールヴィアマーレ(神奈川県)
Year and Date
2011-12-01
Related Report
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[Presentation] Y染色体のハプログループを利用した民族推定法の開発2010
Author(s)
室友紀, 今村真二, 渡部有希菜, 中村博明, 藤原純子, 飯田礼子, 安田年博, 木村かおり, 湯浅勲, 副島美貴子, 神田芳郎, 竹下治男
Organizer
日本DNA多型学会第19回学術集会
Place of Presentation
三島市(静岡県)
Year and Date
2010-11-18
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