The research on the clinical characters of malignant neoplasm andthe origin of the causative-gene mutation in Werner's syndrome.
| Project/Area Number |
21590755
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
General internal medicine (including Psychosomatic medicine)
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| Research Institution | The University of Tokyo |
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Principal Investigator |
TAKEUCHI Fujio 東京大学, 医学部付属病院, 講師 (70154979)
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| Co-Investigator(Kenkyū-buntansha) |
HARIHARA Shinnji 東京大学, 大学院・理学系研究科, 助教 (40198932)
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| Research Collaborator |
PARK Myoung hee 韓国ソウル大学, 医学部, 教授
SONG Yeong wook 韓国ソウル大学, 医学部, 教授
YU Chia-li 台湾台湾大学, 医学部, 教授
WORAWIT Louthrenoo タイチェンマイ大学, 医学部, 教授
SA-NGA Pattanakitsul タイマヒドン大学, 医学部, 准教授
PHAN Thi hoan ハノイ医科大学, 医学部, 准教授
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2011: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2010: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2009: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
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| Keywords | ウエルナー症候群 / 症例報告 / データーベース / 発癌 / 民族差 / WRN遺伝子 / ハプロタイプ / 変異起源 / 重複癌 / 多型 |
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| Research Abstract |
The clinical characters of the malignant neoplasm caused by the causative gene of Werner's syndrome and the origin of the mutation of the gene were investigated. The database(WELTAC1) was constituted of case-reports in Japan. Several cases showed neither consanguineous marriage nor familial history, and it indicates these two items are not suitable as mandatory fields for the diagnosis of the disease. The estimated-frequencies of gastric cancer, lung cancer, breast cancer, et al., and the estimated-age of onset for mesenchymal tumors were almost equal to those in general population. Fifteen cases in 20 cases of multiple neoplasm showed non-epithelial neoplasm. The SNP analysis revealed the ethnical differences in haplotype distribution and it would be relevant to the origin of the mutation of causative gene.
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Report
(4 results)
Research Products
(25 results)
