Analysis of Target Molecules and Pathogenesis with Traditional Japanese Medicine on the Mechanism of Hypoxic Adaptative Response

• Project/Area Number: 21590758
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: General internal medicine (including Psychosomatic medicine)
• Research Institution: University of Toyama
• Principal Investigator: GOTO Hirozo 富山大学, 大学院・医学薬学研究部, 准教授 (40313598)
• Co-Investigator(Kenkyū-buntansha): HIKIAMI Hiroaki 富山大学, 大学病院, 講師 (70345586)
• Project Period (FY): 2009 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2009: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
• Keywords: 東洋医学 / 低酸素誘導因子 / 八味地黄丸 / 桂枝茯苓丸 / 血管内皮成長因子 / アジュバント関節炎ラット

Research Abstract

Recently the hypoxic state of the biological body and the activation of hypoxia inducible factor(HIF) has attracted attention. HIF has been also reported to influence the end-stage of renal failure. In this study, we studied the effect of hachimijiogan on HIF levels in renal failure rats. The results were that the administration of hachimijiogan decreased the uric protein and increased the amount of HIF protein in the renal cortex. Furthermore we studied the active components of hachimijiogan using renal tubular epithelial cultured cells. Cinnamaldehyde and paonol were found to increase the amount of HIF.

Research Products

• [Journal Article] Effect of Hachimijiogan against Renal Dysfunction and Involvement of Hypoxia-Inducible Factor-1alpha in the Remnant Kidney Model (2011)
  • Author(s): Oka H., Goto H., Koizumi K., Nakamura S., Tsuneyama K., Zhou Y., Jo M., Fujimoto T., Sakurai H., Shibahara N., Saiki I., and Shimada Y.
  • Journal Title: Evid Based Complement Alternat Med Volume: 348686
  • Peer Reviewed
• [Journal Article] Cinnamaldehyde and paeonol increase HIF-1αactivity in proximal tubular epithelial cells under hypoxia (2011)
  • Author(s): Oka H., Goto H., Koizumi K., Nogami T., Watari H., Nakamura S., Zhou Y., Sakurai H., Shibahara N., Saiki I., Shimada Y.
  • Journal Title: Journal of Traditional Medicine Volume: 28 Pages: 149-157
  • NAID: 40019169427
  • Peer Reviewed
• [Journal Article] Cinnamaldehyde and paeonol increase HIF-1α activity in proximal tubular epithelial cells under hypoxia (2011)
  • Author(s): Hiroshi Oka
  • Journal Title: Journal of Traditional Medicine Volume: 28 Pages: 149-157
  • Peer Reviewed
• [Journal Article] Effect of Hachimijiogan against Renal Dysfunction and Involvement of Hypoxia-Inducible Factor-1α in the Remnant Kidney Model (2011)
  • Author(s): Hiroshi Oka
  • Journal Title: Evidence-Based Complementary and Alternative Medicine
  • Peer Reviewed
• [Presentation] 腎機能障害に対する八味地黄丸の効果と低酸素適応応答因子の関与 (2010)
  • Author(s): 岡洋志,後藤博三,小泉桂一,引網宏彰,藤本誠,野上達也,済木育夫,嶋田豊
  • Organizer: 第27回和漢医薬学会学術大会
  • Place of Presentation: 京都
• [Presentation] 腎機能障害に対する八味地黄丸の効果と低酸素適応応答因子の関与 (2010)
  • Author(s): 岡洋志
  • Organizer: 第27回和漢医薬学会学術大会
  • Place of Presentation: 京都薬科大学
• [Patent(Industrial Property Rights)] 低酸素応答因子の増強剤および増強方法 (2010)
  • Inventor(s): 後藤博三、岡洋志、小泉桂一
  • Industrial Property Rights Holder: 富山大学
  • Filing Date: 2010-08-18
• [Patent(Industrial Property Rights)] 低酸素応答因子の増強剤および増強方法 (2010)
  • Inventor(s): 後藤博三、岡洋志、小泉桂一
  • Industrial Property Rights Holder: 富山大学
  • Filing Date: 2010-08-18
• [Patent(Industrial Property Rights)] 低酸素応答因子の増強剤およひ"増強方法 (2010)
  • Inventor(s): 後藤博三、岡洋志、小泉桂一
  • Industrial Property Rights Holder: 富山大学
  • Industrial Property Number: 2010-182680
  • Filing Date: 2010-08-18
• [Patent(Industrial Property Rights)] 低酸素応答因子の増強剤およひ"増強方法 (2010)
  • Inventor(s): 後藤博三、岡洋志、小泉桂一
  • Industrial Property Rights Holder: 富山大学
  • Industrial Property Number: 2010-182714
  • Filing Date: 2010-08-18