Investigation of the regression of advanced atherosclerosis through the regulation of cellular senescence-custom-made therapy to Japanese elderly-

• Project/Area Number: 21590762
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: General internal medicine (including Psychosomatic medicine)
• Research Institution: Nagoya University
• Principal Investigator: HAYASHI Toshio 名古屋大学, 医学部附属病院, 講師 (80303634)
• Co-Investigator(Kenkyū-buntansha): UMEGAKI Hiroyuki 名古屋大学, 医学部附属病院, 助教 (40345898)
• Project Period (FY): 2009 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2011: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000); Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2009: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
• Keywords: 抗老化 / 動脈硬化性疾患 / 遺伝子制御 / 一酸化窒素 / 内皮機能制御 / 動脈硬化症 / 細胞老化 / エストロゲン / 糖尿病 / 動脈硬化退縮 / 血管内皮細胞

Research Abstract

Aging is associated with diabetes and dyslipidemia as atherosclerosis characterized by endothelial dysfunction and oxidative stress leading NO destruction. We introduce one example. High glucose especially causes stress-induced premature and replicative senescence. We examined the regulatory role of various products on NO bioavailability, endothelial senescence and its functions. Exposure of HUVECs to high glucose for increased SA-βgalactosidase activity, a senescence marker, and decreased telomerase activity, a replicative senescence marker. We found the anti-senescent effect of statin, estrogen and citrulline. eNOSsiRNA reduced those effects. Streptozotocin-induced diabetes showed more senescent cells in endothelium of aged rats compared with age-matched control and insulin, statin or estrogen-treated rats. The regulatory effects of various products on endothelial senescence might be important for elderly medicine.

Research Products

• [Journal Article] Management of type IIb dyslipidemia J Atheroscl Thoromb (2012)
  • Author(s): Arai H, Ishibashi S, Bujo H, Hayashi T, Yamada N., et al.
• [Journal Article] Back-ground to discuss guidelines for control of plasma HDL-cholesterol in Japan : A revised edition of the report on the meeting of the Research Group for the Management of Primary Hyperlipidemia J Atheroscl Thoromb (2012)
  • Author(s): Yokoyama S, Yamashita S, Hayashi T, Yamada N., et al.
• [Journal Article] Age, gender, insulin and blood glucose control statusalter the risk of ischemic heart disease and stroke among elderly diabetic patients (2012)
  • Author(s): Hayashi T, Kawashima S, Nomura H, et al.
  • Journal Title: Cardiovasc Diabetol
• [Journal Article] Management of type I and V hyperlipidemia The Research Committee for Primary Hyperlipidemia Research on Measures against Intractable Diseasesby the Ministry of Health, Labor, and Welfare in Japan (2012)
  • Author(s): Gotoda T, Arai H, Hayashi T, Yamada N, et al.
  • Journal Title: J A T Volume: 19 Pages: 1-12
• [Journal Article] Short-term effects of L-citrulline on arterial stiffness in middle-aged men (2012)
  • Author(s): Ochiai M, Hayashi T, et al.
  • Journal Title: Int. J. Cardiology Volume: 155 Pages: 257-261
• [Journal Article] Short-term effects of L-citrulline supplementation on arterial stiffness in middle-aged men (2012)
  • Author(s): Ochiai M, Hayashi T, Morita M, Ina K, Maeda M, Watanabe F, Morishita K
  • Journal Title: Int.J.Cardiology Volume: 155 Issue: 2 Pages: 257-261
  • DOI: 10.1016/j.ijcard.2010.10.004
  • Peer Reviewed
• [Journal Article] Background to Discuss Guidelines for Control of Plasma HDL-Cholesterol in Japan* (2012)
  • Author(s): Yokoyama S, Yamashita S, Ishibashi S, Sone H, Oikawa S, Shirai K, Ohta T, Bujo H, Kobayashi J, Arai H, Harada-Shiba M, Eto M, Hayashi T, Gotoda T, Suzuki H, Yamada N
  • Journal Title: Journal of Atherosclerosis and Thrombosis Volume: 19 Issue: 3 Pages: 207-212
  • DOI: 10.5551/jat.11452
  • NAID: 130004444591
  • ISSN: 1340-3478, 1880-3873
  • Peer Reviewed
• [Journal Article] Management of Type IIb Dyslipidemia (2012)
  • Author(s): Arai H, Ishibashi S, Bujo H, Hayashi T, Yokoyama S, Oikawa S, Kobayashi J, Shirai K, Ota T, Yamashita S, Gotoda T, Harada-Shiba M, Sone H, Eto M, Suzuki H, Yamada N.
  • Journal Title: Journal of Atherosclerosis and Thrombosis Volume: 19 Issue: 2 Pages: 105-114
  • DOI: 10.5551/jat.10447
  • NAID: 130004444573
  • ISSN: 1340-3478, 1880-3873
  • Peer Reviewed
• [Journal Article] Diagnosis and Management of Type I and Type V Hyperlipoproteinemia (2012)
  • Author(s): Gotoda T, Shirai K, Ohta T, Kobayashi J, Yokoyama S, Oikawa S, Bujo H, Ishibashi S, Arai H, Ya mashita S, Harada-Shiba M, Eto M, Hayashi T, Sone H, Suzuki H, Yamada N
  • Journal Title: Journal of Atherosclerosis and Thrombosis Volume: 19 Issue: 1 Pages: 1-12
  • DOI: 10.5551/jat.10702
  • NAID: 130004721898
  • ISSN: 1340-3478, 1880-3873
  • Peer Reviewed
• [Journal Article] et al Dose-DependentModulatory Effects of Insulin on Glucose-induced Endothelial Senescence invitro and in vivo (2011)
  • Author(s): Matsui-Hirai H, Hayashi T, Ignarro LJ, Hattori Y.
  • Journal Title: J Pharmacol Exp Ther Volume: 337 Pages: 591-599
• [Journal Article] Depression, quality of life(QoL) and will to live of community-dwelling postmenopausal women in three Asian countries : Korea (2011)
  • Author(s): Ina K, Hayashi T, et al.(他4名2番目)
  • Journal Title: Archive Ger. Gel Volume: 53 Pages: 8-12
• [Journal Article] The effects of selective estrogen receptor modulator treatment following hormone replacement therapy on elderly postmenopausal women with osteoporosis (2011)
  • Author(s): Hayashi T, Ina K, Maeda M, Nomura H.
  • Volume: 34
  • Pages: 199-203
• [Journal Article] Place of death for the elderly in need of end-of-life home care : Astudy in Japan (2011)
  • Author(s): Hayashi T, Nomura H, et. al.
  • Journal Title: Arch Gerontol Geriatr Volume: 53 Pages: 242-244
• [Journal Article] Enodothelial Progenitor Cells as Therapeutic Agents in the Microcirculation. Atherosclerosis (2011)
  • Author(s): Napoli C, Cacciatore F, Hayashi T, Ignarro LJ, et al.
  • Volume: 215
  • Pages: 9-22
• [Journal Article] The role of insulin growth factor on atherosclerosis and endothelial function : The effect onhyper-lipidemia and aging. (2011)
  • Author(s): Hirai H, Maeda M, Qungfang D, Hayashi T.
  • Journal Title: Life Sci Volume: 88 Pages: 425-31
• [Journal Article] Place of death for the elderly in need of end-of-life home care : A study in Japan (2011)
  • Author(s): Hayashi T, Nomura H, Ina K, Kato T, Hirose T, Nonogaki Z, Suzuki Y
  • Journal Title: Arch Gerontol Geriatr Volume: 53 Issue: 2 Pages: 242-244
  • DOI: 10.1016/j.archger.2010.12.005
  • Peer Reviewed
• [Journal Article] Depression, quality of life (QoL) and will to live of community-dwelling postmenopausal women in three Asian countries : Korea, China and Japan (2011)
  • Author(s): Ina K, Hayashi T, Nomura H, Ishitsuka A, Hirai H, Iguchi A
  • Journal Title: Arch Gerontol Geriatr. Volume: 53 Issue: 1 Pages: 8-12
  • DOI: 10.1016/j.archger.2010.05.010
  • Peer Reviewed
• [Journal Article] The role of insulin growth factor on atherosclerosis and endotbelial function : the effect on hyperlipidemia and aging (2011)
  • Author(s): Hirai H, Kanaya R, Maeda M, Qungfang D, Ina K, Hayashi T
  • Journal Title: Life Sci Volume: 88 Issue: 9-10 Pages: 425-431
  • DOI: 10.1016/j.lfs.2010.12.021
  • Peer Reviewed
• [Journal Article] Enodothelial Progenitor Cells as Therapeutic Agents in the Microcirculation (2011)
  • Author(s): Napoli C, Cacciatore F, Hayashi T, Casamassimi A, Casini C, Al-Omran M, Ignarro L.J.
  • Journal Title: Atherosclerosis Volume: 215 Issue: 1 Pages: 9-22
  • DOI: 10.1016/j.atherosclerosis.2010.10.039
  • Peer Reviewed
• [Journal Article] insulin and blood glucose control status alter the risk of ischemic heart disease and stroke among elderly diabetic patients (2011)
  • Author(s): Hayashi T, Kawashima S, Nomura H, Itoh H, Wa tanabe H, Ohrui T, Yokote K, Sone H, Hattori Y, Yoshizumi M, Ina K, Kubota K. Age, gender
  • Journal Title: Cardiovasc Diabetol Volume: 10 Issue: 1 Pages: 86-86
  • DOI: 10.1186/1475-2840-10-86
  • Peer Reviewed
• [Journal Article] The effects of selective estrogen receptor modulator treatment following hormone replacement therapy on elderly postmenopausal women with osteoporosis (2011)
  • Author(s): Hayashi T, Ina K, Maeda M, Nomura H
  • Journal Title: Nitric Oxide Volume: 24 Issue: 4 Pages: 199-203
  • DOI: 10.1016/j.niox.2011.04.002
  • Peer Reviewed
• [Journal Article] Dose-Dependent Modulatory Effects of Insulin on Glucoseinduced Endothelial Senescence in vitro and in vivo : A Relationship between Telomeres and Nitric Oxide (2011)
  • Author(s): Matsui-Hirai H, Hayashi T, Yamamoto S, Ina K, Maeda M, Kotani H, Iguchi A, Ignarro L.J., Hattori Y
  • Journal Title: J Pharmacol Exp Ther Volume: 337 Issue: 3 Pages: 591-599
  • DOI: 10.1124/jpet.110.177584
  • Peer Reviewed
• [Journal Article] Dose-Dependent Modulatory Effects of Insulin on Glucose-induced Endothelial Senescence in vitro and in vivo A Relationship between Telomeres and Nitric Oxide (2011)
  • Author(s): Matsui-Hirai H, Hayashi T, Yamamoto S, 他6名2番目
  • Journal Title: J Pharmacol Exp Ther Volume: 印刷中
  • Peer Reviewed
• [Journal Article] Place of death for the elderly in need of end-of-life home care A study in Japan. (2011)
  • Author(s): Hayashi T, Nomura H, 他5名1番目
  • Journal Title: Arch Gerontol Geriatr Volume: 印刷中
  • Peer Reviewed
• [Journal Article] Short-term effects of L-citrulline supplementation on arterial stiffness in middle-aged men (2011)
  • Author(s): Ochiai M, Hayashi T, Morita M, 他4名2番目
  • Journal Title: Int.J.Cardiology Volume: 印刷中
  • Peer Reviewed
• [Journal Article] Depression, quality of life (QoL) and will to live of community-dwelling postmenopausal women in three Asian countries. Korea, China and Japan. (2011)
  • Author(s): Ina K, Hayashi T, Nomuraa H, Ishitsukaa A, Hirai H, Iguchi A.
  • Journal Title: Archive Ger.ontol Geriatr Volume: 印刷中
  • Peer Reviewed
• [Journal Article] Enodothelial Progenitor Cells as Therapeutic Agents in the Microcirculation. (2011)
  • Author(s): Napoli C, Cacciatore F, Hayashi T, 他4名3番目
  • Journal Title: Atherosclerosis Volume: 215 Pages: 9-22
  • Peer Reviewed
• [Journal Article] The role of insulin growth factor on atherosclerosis and endothelial function : The effect on hyperlipidemia and aging. (2011)
  • Author(s): Hirai H, Kanaya R, Maeda M, Qungfang D, Ina K, Hayashi T.
  • Journal Title: Life Sci Volume: 88 Pages: 425-431
  • Peer Reviewed
• [Journal Article] Association of lower hemoglobin level with depressive mood in elderly women at high risk of requiring care (2011)
  • Author(s): Umegaki H, Yanagawa M, Endo H.
  • Journal Title: Geriatr Gerontol Int Volume: 印刷中
  • NAID: 10031147962
  • Peer Reviewed
• [Journal Article] Possibility of the regression of atherosclerosis through prevention of endothelial senescence by regulation of nitric oxide and free radical scavengers (2010)
  • Author(s): Hayashi T, Iguchi A.
  • Journal Title: Geriatr Gerontol Int Volume: 10 Pages: 115-130
  • NAID: 10027271886
• [Journal Article] A hydroxymethyl glutaryl coenzyme a reductase inhibitor improves end othe lialfunction within 7 days in patients with chronichemodialysis (2010)
  • Author(s): Kishimoto N, Hayashi T, Sakuma I, et al.
  • Journal Title: Int J Cardiol Volume: 145 Pages: 21-26
• [Journal Article] CXCR4/YY1 inhibition impairs VEGF network and angiogenesis during malignancy Proc Natl Acad Sci U S A. (2010)
  • Author(s): de Nigrisa F, Hayashii T, Ignarro LJ, Napoli C, et al.
  • Volume: 107
  • Pages: 14484-89
• [Journal Article] Beneficial effect of the oligomerized polyphenol oligonol on high glucose-induced changes in eNOS phosphorylation and dephosphorylation in endothelial cells (2010)
  • Author(s): Zhang X-H, Hayashi T, et. al.
  • Journal Title: Br J Pharmacology Volume: 159 Pages: 928-938
• [Journal Article] A glucagonlike peptide-1 analogue, liraglutide, upregulates NO production and exerts anti-inflammatory action in endothelial cells (2010)
  • Author(s): Hattori Y, Hayashi T, et al.
  • Journal Title: Diabetologia Volume: 53 Pages: 2256-63
• [Journal Article] A hydroxymethylglutaryl coenzyme a reductase inhibitor improves endothelial function within 7days in patients with chronic hemodialysis. (2010)
  • Author(s): Kishimoto N, Hayashi T, Sakuma I, Kano-Hayashi H, 他5名2番目
  • Journal Title: Int J Cardiol Volume: 145 Pages: 21-26
  • Peer Reviewed
• [Journal Article] Beneficial effect of the oligomerized polyphenol oligonol on high glucose- induced changes in eNOS phosphorylation and dephosphorylation in endothelial cells (2010)
  • Author(s): Zhang XH, Yokoo H, Nishioka H, Fujii H, Matsuda N, Hayashi T, Hattori Y.
  • Journal Title: Br J Pharmacol Volume: 159 Pages: 928-938
  • Peer Reviewed
• [Journal Article] Possibility of the regression of atherosclerosis through the prevention of endothelial senescence bythe regulation of nitric oxide and free radical scaverigers. (2010)
  • Author(s): Hayashi T, Iguchi A.
  • Journal Title: Geriatr Gerontol Int Volume: 10 Pages: 115-130
  • Peer Reviewed
• [Journal Article] CXCR4/YY1 inhibition impairs VEGF network and angiogenesis during malignancy. (2010)
  • Author(s): de Nigrisa F, Crudelea V, Hayashii T, Ignarroj LJ, Napoli, 他9名3番目
  • Journal Title: Proc Natl Acad Sci USA Volume: 107 Pages: 14484-14489
  • Peer Reviewed
• [Journal Article] Effects of educational background on verbal fluency task performance in older adults with Alaheimer's disease and mild cognitive impairment. (2010)
  • Author(s): Kawano N, Umegaki H, Suzuki Y, Yamamoto S, Mogi N, Iguchi A.
  • Journal Title: Int Psychogeriatr Volume: 22 Pages: 995-1002
  • Peer Reviewed
• [Journal Article] Possibility of the regression of atherosclerosis through the prevention of endothelial senescence by the regulation of nitric oxide and free radical scavengers (2010)
  • Author(s): Hayashi T, Iguchi A
  • Journal Title: Geriatr Gerontol Int. (印刷中)
  • NAID: 10027271886
  • Peer Reviewed
• [Journal Article] A hydroxymethylglutaryl coenzyme a reductase inhibitor improves endothelial function within 7 days in patients with chronic hemodialysis. (2010)
  • Author(s): Kishimoto N, Hayashi T, Sakuma I, Kano-Hayashi H, Tsunekawa T, Osawa M, Ina K, Iguchi A.
  • Journal Title: Int J Cardiol. (印刷中)
  • Peer Reviewed
• [Journal Article] Beneficial effect of the oligomerized polyphenol oligonol on high glucose-induced changes in eNOS phosphorylation and dephosphorylation in endothelial cells. (2010)
  • Author(s): Zhang XH, Yokoo H, Nishioka H, Fujii H, Matsuda N, Hayashi T, Hattori Y.
  • Journal Title: Br J Pharmacol (印刷中)
  • Peer Reviewed
• [Journal Article] Age-Associated Increase in Abdominal Obesity and Insulin Resistance, and Usefulness of AHA/NHLBI Definition of Metabolic Syndrome for Predicting Cardio-vascular Disease in Japanese Elderly with Type 2 Diabetes Mellitus (2010)
  • Author(s): Sakurai T, Iimuro S, Araki A, Umegaki H, Ohashi Y, Yokono K Ito H
  • Journal Title: Gerontology (印刷中)
  • Peer Reviewed
• [Journal Article] Pathophysiology of cognitive dysfunction in older people with type 2 diabetes : vascular changes or neurodegeneration? (2010)
  • Author(s): Umegaki H,
  • Journal Title: Age Ageing. 39 Pages: 8-10
  • Peer Reviewed
• [Journal Article] Clinical factors such as B-typenatriuretic peptide link to factor VII, endothelial NO synthase and estrogen receptor alpha polymorphism in elderly women (2009)
  • Author(s): Funami J, Hayashi T, et al.(他8名2番目)
  • Journal Title: Life Sci Volume: 85 Pages: 316-21
• [Journal Article] HDL relates the risk of stroke in very elderly diabetic individuals : The change in the risk factors for atherosclerotic diseases at various ages (2009)
  • Author(s): Hayashi T, Itoh H, Watanabe H, Iguchi A, et al.
  • Journal Title: Diabetes Care Volume: 32 Pages: 1221-3
• [Journal Article] Low HDL cholesterol is associated with the risk of stroke in elderly diabetic individuals : changes in the risk for atherosclerotic diseases at various ages. (2009)
  • Author(s): Hayashi T, Kawashima S, Itoh H, (他9名1番目), on behalf of Japan CDM group
  • Journal Title: Diabetes Care 32 Pages: 1221-1223
  • Peer Reviewed
• [Journal Article] Clinical factors such as B-type natriuretic peptide link to fact or VII, endothelial NO synthase and estrogen receptor alphapolymorphism in elderly women. (2009)
  • Author(s): Funami J, Hayashi T, Nomura H, Ding QF, Ishitsuka-Watanabe A, Matsui-Hirai H, Ina K, Zhang J, Yu ZY, Iguchi A.
  • Journal Title: Life Sciences 85 Pages: 316-321
  • Peer Reviewed
• [Journal Article] Acute metabolic responses to a high-carbohydrate meal in outpatients with type 2 diabetes treated with a low-carbohydrate diet : a crossover meal tolerance study. (2009)
  • Author(s): Haimoto H, Sasakabe T, Umegaki H, Wakai K
  • Journal Title: Nutr Metab(Lond). 6 Pages: 52-52
  • Peer Reviewed
• [Journal Article] Association of higher carbohydrate intake with depressive mood in elderly diabetic women. (2009)
  • Author(s): Umegaki H, Iimuro S, Araki A, Sakurai T, Iguchi A, (他3名1番目)
  • Journal Title: Nutr Neurosci. 12 Pages: 267-271
  • Peer Reviewed
• [Journal Article] (2009)
  • Author(s): Hayashi T, Iguchi A.
  • Journal Title: Free radicals as atherosclerotic risk-The relation of NO(Chapter 21)(Elsevier Co. Ltd.)
• [Journal Article] Nitric oxide and endothelial cellular senescence (2008)
  • Author(s): Hayashi T, Yano K, et al.
  • Journal Title: Pharmacol Ther Volume: 120 Pages: 333-9
• [Journal Article] Importance of lipid levels in elderly diabetic in dividuals : baseline characteristics and 1-year survey of cardiovascular events (2008)
  • Author(s): Hayashi T, Kawashima S, et al.
  • Journal Title: Circ J Volume: 72 Pages: 218-25
• [Journal Article] Augmentation of vascular remodeling by uncoupled endothelial NO synthase in a mouse model of diabetes mellitus. Arterioscler Thromb Vasc Biol (2008)
  • Author(s): Sasaki N, Hayashi T, Kawashima S, et al.
  • Volume: 28
  • Pages: 1068-76
• [Journal Article] Pitavastat in Shows Promise in Treatment of Patients With Type 2 Diabetes (2008)
  • Author(s): Hayashi T, Iguchi A.
  • Journal Title: Review of Endocrinology Volume: 1 Pages: 1-3
• [Journal Article] Proposed Guideleins for Hypertriglyceridemia in Japan with non-HDL Cholesterol as the second Target (2008)
  • Author(s): Simano H, Arai H, Hayashi T, Yamada N. et al.
  • Journal Title: JA the rosclero Thromb Volume: 15 Pages: 116-121
• [Presentation] 動脈硬化症とアミノ酸ーアルギニン (2011)
  • Author(s): 林登志雄
  • Organizer: 日本アミノ酸学会第4回夏のシンポジウム
  • Place of Presentation: 新潟
  • Year and Date: 2011-09-09
• [Presentation] 動脈硬化症とアミノ酸-アルギニン,シトルリンを中心に- (2011)
  • Author(s): 林登志雄
  • Organizer: 平成23年度日本アミノ酸学会第4回夏のシンポジウム
  • Place of Presentation: 新潟(招待講演)
  • Year and Date: 2011-09-09
• [Presentation] 生活習慣病,老化とアミノ酸 (2011)
  • Author(s): 林登志雄
  • Organizer: 第5回日本アミノ酸学会年次集会
  • Place of Presentation: 名古屋
• [Presentation] 脂質異常症合併糖尿病患者の薬物療法における医療経済解析用アセスメントモデル (2011)
  • Author(s): 伊奈孝一郎,林登志雄
  • Organizer: 第54回日本糖尿病学会年次学術集会
  • Place of Presentation: 日札幌
• [Presentation] Seoul Korea Special Invited Lecture. Clinica Approach for Atherosclerosis in Elderly (2011)
  • Author(s): Hayashi T.
  • Organizer: The 20^<th> Korea Lipid and Atherosclerosis Society Annual Meeting
• [Presentation] 在宅医療において在宅死を規定する因子についての検討 (2011)
  • Author(s): 伊奈孝一郎, 林登志雄, 野村秀樹, 広瀬貴久, 野々垣禅, 鈴木祐介
  • Organizer: 第53回日本老年医学会学術集会
  • Place of Presentation: 東京
• [Presentation] 糖尿病合併脂質異常症患者薬物療法における医療経済解析のためのアセスメントモデル (2011)
  • Author(s): 伊奈孝一郎, 林登志雄
  • Organizer: 第53回日本老年医学会学術集会
  • Place of Presentation: 東京
• [Presentation] 糖尿病合併心血管病への動脈硬化危険因子の影響-5年度調査- (2011)
  • Author(s): 林登志雄, 伊奈孝一郎, 野村秀樹, 大類孝, 他5名
  • Organizer: 第53回日本老年医学会学術集会
  • Place of Presentation: 東京
• [Presentation] 高血圧モデル・アンギオテンシンIIによる血管内皮細胞老化はHMG-CoA還元酵素阻害剤により回復する (2011)
  • Author(s): 林登志雄, 伊奈孝一郎
  • Organizer: 第53回日本老年医学会学術集会
  • Place of Presentation: 東京
• [Presentation] 細胞老化抑制物質の検討-高グルコースモデルを用いて- (2011)
  • Author(s): 林登志雄, 伊奈孝一郎
  • Organizer: 第53回日本老年医学会学術集会
  • Place of Presentation: 東京
• [Presentation] 脂質異常症合併糖尿病患者の薬物療法における医療経済解析用アセスメントモデル (2011)
  • Author(s): 伊奈孝一郎, 林登志雄
  • Organizer: 第54回日本糖尿病学会学術集会
  • Place of Presentation: 札幌
• [Presentation] 生活習慣病、老化とアミノ酸 (2011)
  • Author(s): 林登志雄
  • Organizer: 日本アミノ酸学会第5回学術大会(JSAAS 2011)
  • Place of Presentation: 名古屋(招待講演)
• [Presentation] Low HDL-Cholesterol is Associated With Risk of Ischemic heart disease and Stroke in Elderly Diabetic Individuals (2011)
  • Author(s): Hayashi T, Ina K, Nomura H, on behalf of JCDM investigators
  • Organizer: 9^<th> Asia/Oceania Regional Congress of Gerontology and Geriatrics Gerontology and Geriatrics
  • Place of Presentation: Melbourune Australia
• [Presentation] Dose-Dependent Modulatory Effects of Insulin on Glucose-induced Endothelial Senescence in vitro and in vivo : A Relationship between Telomeres and Nitric Oxide (2011)
  • Author(s): Hayashi T, Hirai H, Ina K, Nomura H
  • Organizer: 9^<th> Asia/Oceania Regional Congress of Gerontology and Geriatrics Gerontology and Geriatrics
  • Place of Presentation: Melbourune Australia
• [Presentation] 愛知県における原発性高脂血症の実態と診療の在り方-早期診断と在宅医療 (2010)
  • Author(s): 林登志雄
  • Organizer: 愛知県難病研究会特別講演
  • Place of Presentation: 愛知県
  • Year and Date: 2010-11-24
• [Presentation] Clinical Approach for Atherosclerosis in Elderly (2010)
  • Author(s): Hayashi T
  • Organizer: The 20^<th> Korea Lipid and Atherosclerosis Society Annual Meeting Special Invited Lecture
  • Place of Presentation: Seoul, Korea(特別招待講演)
  • Year and Date: 2010-09-07
• [Presentation] 糖尿病合併脂質異常症の心血管病危険因子としての寄与-複合型高脂血症を中心とした年齢別検討 (2010)
  • Author(s): 伊奈孝一郎,林登志雄, 他2名2番目
  • Organizer: 第52回日本老年医学会学術集会
  • Place of Presentation: 神戸
  • Year and Date: 2010-06-26
• [Presentation] 高齢者ワーファリン治療の留意点 (2010)
  • Author(s): 広瀬貴久、林登志雄
  • Organizer: 第52回日本老年医学会学術集会
  • Place of Presentation: 神戸
  • Year and Date: 2010-06-25
• [Presentation] 食後高血糖モデルグルコース間歌刺激は新しい機序で血管内皮細胞を老化させる (2010)
  • Author(s): 林登志雄, 他3名1番目
  • Organizer: 第52回日本老年医学会学術集会
  • Place of Presentation: 神戸
  • Year and Date: 2010-06-25
• [Presentation] 糖尿病合併心血管病危険因子の検討-高齢者インスリン治療- (2010)
  • Author(s): 林登志雄, 他3名1番目
  • Organizer: 第52回日本老年医学会学術集会
  • Place of Presentation: 神戸
  • Year and Date: 2010-06-25
• [Presentation] 老化と内皮機能障害/動脈硬化 (2010)
  • Author(s): 林登志雄
  • Organizer: 第52回日本老年医学会学術集会シンポジウム
  • Place of Presentation: 神戸
  • Year and Date: 2010-06-24
• [Presentation] 血管老化を標的としたNOを介する抗動脈硬化療法-グルコース及びインスリンの作用を中心に (2010)
  • Author(s): 林登志雄
  • Organizer: 第34回日本基礎老化学会学術集会シンポジウム
  • Place of Presentation: 名古屋
  • Year and Date: 2010-06-19
• [Presentation] Angiotensm II stimuli, model of hypetension, induced endothelial senenscence is totally restored by HMG CoA reductase inhibitor (2010)
  • Author(s): 榊原泰史、前田守彦、伊奈孝一郎、平井寿子、林登志雄
  • Organizer: 第34回日本基礎老化学会学術集会ワークショップ
  • Place of Presentation: 名古屋
  • Year and Date: 2010-06-19
• [Presentation] Intermittent high glucose stimuli promote endonthelial senescence Model of impaired glucose tolerance (2010)
  • Author(s): 前田守彦、林登志雄, 他3名5番目
  • Organizer: 第34回日本基礎老化学会学術集会ワークショップ
  • Place of Presentation: 名古屋
  • Year and Date: 2010-06-19
• [Presentation] Differences in the risk of stroke and ischemic heart disease by age among diabet ic patients receiving insulin therapy. (2010)
  • Author(s): Hayashi T, 他3名1番目
  • Organizer: Annual Scientific Meeting American Geriatrics Society
  • Place of Presentation: Orlando, Fl, USA
  • Year and Date: 2010-05-08
• [Presentation] Depression, quality of life and will to live of community- dwelling postmenopa usal women in three Asian countries Korea, China and Japan (2010)
  • Author(s): Ina K, Hayashi T, Nomura H, Ishitsuka A, Hirai H, Iguchi A.
  • Organizer: Annual Scientific Meeting American Geriatrics SOCIETY
  • Place of Presentation: Orlando, Fl, USA
  • Year and Date: 2010-05-08
• [Presentation] 老化と内皮機能障害/動脈硬化 (2010)
  • Author(s): 林登志雄
  • Organizer: 第52回日本老年医学会学術集会
  • Place of Presentation: 神戸
• [Presentation] Interactions of glucose and insulin in regulation of replicative and stress-induced endothelial senescence (2010)
  • Author(s): Hayashi T
  • Organizer: 14^<th> In ternational Congress of Endocrinology
  • Place of Presentation: Kyoto
• [Presentation] A new view of atheroslcerosis related pharmacogenetics based gene analysis in Japanese elderly women (2010)
  • Author(s): K Ina, T. Hayashi, et al.
  • Organizer: The10^<th> International Symposium on Mechanisms of Vasodiatation
  • Place of Presentation: Matsushima, Miyagi
• [Presentation] 優秀演題血管内皮細胞老化におけるグルコースとインシュリン (2010)
  • Author(s): 林登志雄,他
  • Organizer: 第52回日本糖尿病学会学術集会
  • Place of Presentation: 大阪
• [Presentation] Interactions of glucose and insulin in regulation of replicative and stress-induced endothelial senescence-The relationship between telomere and nitric oxide- (2009)
  • Author(s): Hayashi T.Mastsui-Hirai H
  • Organizer: America's Gerontology Society 62nd Annual Scientific Meeting
  • Place of Presentation: Atlanta, USA
  • Year and Date: 2009-11-19
• [Presentation] Depression, Quality of Life and Living will of community-dwelling postmen opausal and elderly women in three asian countries, Japan, Korea and China. (2009)
  • Author(s): Ina K, Hayashi T
  • Organizer: 19^<th> IAGG World Congress of Gerontology and Geriatrics
  • Place of Presentation: Paris, France
  • Year and Date: 2009-07-06
• [Presentation] Low HDL-cholesterol is associated with the stroke risk in elderly diabetic individuals. (2009)
  • Author(s): Hayashi T, (他10名1番目)
  • Organizer: 19^<th> IAGG World Congress of Gerontology and Geriatrics
  • Place of Presentation: Paris, France
  • Year and Date: 2009-07-05
• [Presentation] Low HDL- cholesterol is associated with the risk of stroke in elderly diabetic individuals : Changes in the risk for atherosclerotic diseases at various ages. (2009)
  • Author(s): Hayashi T., (他10名1番目)
  • Organizer: American Diabetes Association's 69th Scientific Sessions
  • Place of Presentation: New Orleans, USA
  • Year and Date: 2009-06-06
• [Presentation] A new view of atherosclerosis related pharmacogenetics based gene analysis in Japanese elderly women. (2009)
  • Author(s): K Ina, T.Hayashi
  • Organizer: The 10^<th> International Symposium on Mechanisms of Vasodiatation
  • Place of Presentation: Matsushima, Miyagi, JAPAN
  • Year and Date: 2009-06-02
• [Presentation] Biphsic effects of insulin on endothelial senescence. (2009)
  • Author(s): K Ina, T.Hayashi
  • Organizer: The 10^<th> International Symposium on Mechanisms of Vasodiatation
  • Place of Presentation: Matsushima, Miyagi, JAPAN
  • Year and Date: 2009-06-02
• [Presentation] 糖尿病罹患者における脳卒中リスクとしての脂質の影響-年齢による危険因子の変化- (2009)
  • Author(s): 伊奈孝一郎、林登志雄
  • Organizer: 第52回日本糖尿病学会学術集会優秀演題
  • Place of Presentation: 大阪
  • Year and Date: 2009-05-23
• [Presentation] 血管内皮細胞老化におけるグルコースとインシュリンの役割 (2009)
  • Author(s): 林登志雄, (他3名1番目)
  • Organizer: 第52回日本糖尿病学会学術集会優秀演題
  • Place of Presentation: 大阪
  • Year and Date: 2009-05-22
• [Presentation] 「シトルリン・疾患治療への応用と展望」シトルリン～NO産生と動脈硬化予防への展望 (2009)
  • Author(s): 林登志雄
  • Organizer: 第9回日本NO学術集会 セミナー
  • Place of Presentation: 静岡
  • Year and Date: 2009-05-09
• [Presentation] グルコースとインスリンの細胞老化ストレスを介する動脈硬化への作用 (2009)
  • Author(s): 林登志雄
  • Organizer: 第9回日本NO学術集会 シンポジウムNOとインスリン抵抗性-糖尿病・老化)
  • Place of Presentation: 静岡
  • Year and Date: 2009-05-08
• [Presentation] The role of glucose and insulin on endothelial senescence-The relation of diversity effect of insulin and telomerase- (2009)
  • Author(s): Hayashi T., (他3名1番目)
  • Organizer: Annual Scientific Meeting American Geriatrics Society
  • Place of Presentation: Chicago USA
  • Year and Date: 2009-05-03
• [Presentation] America's Gerontology Society 62nd Annual Scientific Meeting (2009)
  • Author(s): Hayashi T, et al.
  • Organizer: Interactions ofglucose and insulin in regulation of replicativeand stress-induced senescence
  • Place of Presentation: Atlanta, GA, Late Breaker Session
• [Presentation] Short-term effects of L-citrulline supplementation on arterial stiffness in middle-aged men (2009)
  • Author(s): M. Ochiai、T. Hayashi
  • Organizer: 第41回日本動脈硬化学会学術集会
  • Place of Presentation: 下関
• [Presentation] Low HDL-cholesterol is associated with stroke in elderly diabetic individuals (2009)
  • Author(s): Hayashi T, et al.
  • Organizer: 19^<th>IAGG World Congress of Gerontology and Geriatric Paris
• [Presentation] HDL regulates the risk of stroke in very elderly diabetic individuals-The change in the risk factors at various ages (2009)
  • Author(s): T. Hayashi, et al.
  • Organizer: The American Diabetes Association's 69th Scientific Sessions New Orleans
• [Presentation] Biphsic effects of insulin on endo the lial senescence (2009)
  • Author(s): K Ina, T. Hayashi, et al.
  • Organizer: The10^<th> International Symposium on Mechanisms of Vasodiatation
  • Place of Presentation: Matsushima, Miyagi
• [Presentation] 優秀演題糖尿病罹患者における脳卒中リスクとしての脂質の影響.年齢による危険因子の変化- (2009)
  • Author(s): 伊奈孝一郎,林登志雄,他
  • Organizer: 第52回日本糖尿病学会学術集会
  • Place of Presentation: 大阪
• [Presentation] グルコースとインスリンの細胞老化ストレスを介する動脈硬化への作用 (2009)
  • Author(s): 林登志雄
  • Organizer: 第9回日本NO学術集会
  • Place of Presentation: 静岡
• [Presentation] シトルリン～NO産生と動脈硬化予防への展望 (2009)
  • Author(s): 林登志雄
  • Organizer: 第9回日本NO学術集会
  • Place of Presentation: 静岡
• [Presentation] 閉経後高齢女性におけるラロキシフェンの有用性の検討-HRTからの移行例との比較試験成績から (2009)
  • Author(s): 伊奈孝一郎,林登志雄
  • Organizer: 第9回日本NO学術集会
  • Place of Presentation: 静岡
• [Presentation] HMG CoA還元酵素阻害剤は慢性透析患者にPleiotropic効果として (2009)
  • Author(s): 伊奈孝一郎,林登志雄,他
  • Organizer: 第9回日本NO学術集会
  • Place of Presentation: 静岡
• [Presentation] 日本人高齢女性における遺伝子変異解析に基づく、遺伝薬理学関連動脈硬化症の可能性の検討 (2009)
  • Author(s): 麻子,林登志雄
  • Organizer: 第9回日本NO学術集会
  • Place of Presentation: 静岡
• [Presentation] IGF-1(インスリン様細胞成長因子の動脈硬化症への影 (2009)
  • Author(s): 林登志雄
  • Organizer: 第9回日本NO学術集会
  • Place of Presentation: 静岡
• [Presentation] L-シトルリン短期間摂取がヒトの血管弾性に及ぼす影響落合将之 (2009)
  • Author(s): 落合将之,林登志雄
  • Organizer: 第9回日本NO学術集会
  • Place of Presentation: 静岡
• [Presentation] エストロゲン及び一酸化窒素の老化シグナルへの影響 (2009)
  • Author(s): 平井寿子、林登志雄
  • Organizer: 第9回日本NO学術集会
  • Place of Presentation: 静岡
• [Presentation] The role of glucose and insulin on endothelial senescence-The relation of diversity effect of insulin (2009)
  • Author(s): Hayashi T, et al.
  • Organizer: The American Geriatrics Society 2009 Annual Scientific Meeting
  • Place of Presentation: Chicago, IL, USA
• [Presentation] With Risk of Is chemic heart disease and Stroke in Elderly Diabetic Patients
  • Author(s): Hayashi T, Ina K, et al.
  • Organizer: Low HDL-Cholesterol is Associated
• [Presentation] A Relationship be tween Telomeres and NO
  • Author(s): Hayashi T, et al.
  • Organizer: Dose-Dependent Modulatory Effects ofInsulin on Glucose-induced Endothelial Senescence in vitro and in vivo
• [Presentation] Place of death for the elderly in need offend-of-life home care
  • Author(s): Ina K, Hayashi T, et al.
• [Presentation] 糖尿病合併心血管病への動脈硬化危険因子の影響
  • Author(s): 林登志雄他9名
• [Presentation] 高血圧モデル・アンギオテンシンIIによる血管内皮細胞老化はHMG-CoA還元酵素阻害剤により回復する
  • Author(s): 林登志雄,伊奈孝一郎
• [Presentation] 細胞老化抑制物質の検討.高グルコースモデルを用いて
  • Author(s): 林登志雄,伊奈孝一郎
• [Presentation] 在宅医療において在宅しを規定する因子について検討
  • Author(s): 伊奈孝一郎,林登志雄他4名
• [Presentation] 糖尿病患者薬物療法医療経済解析のためのアセスメントモデル
  • Author(s): 伊奈孝一郎,林登志雄
• [Presentation] Differences in the risk of stroke and ischemic heart disease by age among diabe tics with insulin
  • Author(s): Hayashi T, et al.
• [Presentation] Depression, quality of life and will to live of community-dwelling postmenopausal women in : Korea, China and Japan
  • Author(s): Ina K, Hayashi T, et al.
• [Presentation] Depression, Quality of Life and Living will of postmenopausal elderly women in east asia, Japan, Korea and China
  • Author(s): Ina K, Hayashi T.
  • Organizer: 19^<th>IAGG World Congress of Gerontology and Geriatric Paris
• [Presentation] 糖尿病合併心血管病危険因子の検討-日本人の脂質の寄与の年代差
  • Author(s): 林登志雄
• [Presentation] 本邦高齢女性の動脈硬化関連遺伝子変異病態解析の有用性
  • Author(s): 伊奈孝一郎,林登志雄
• [Presentation] グルコースとインシュリンの細胞老化と動脈硬化への作用(2報)
  • Author(s): 林登志雄
• [Presentation] 東アジア3カ国閉経後から後期高齢女性の精神, QOLの検討
  • Author(s): 伊奈孝一郎,林登志雄
• [Presentation] 血管老化を標的とした一酸化窒素,活性酸素制御を介する動脈硬化退縮療法
  • Author(s): 林登志雄
  • Organizer: 老化及び老年医学研2007年度受賞者講演
• [Book] 疾患からみた薬理学渡邉裕司編改訂3版骨粗鬆症 (2011)
  • Author(s): 林登志雄
• [Book] 疾患からみた薬理学改訂3版骨粗鬆症 (2011)
  • Author(s): 林登志雄
  • Publisher: じほう社
• [Book] 骨粗霧症 (2011)
  • Author(s): 林登志雄
  • Publisher: じほう社
• [Book] Nitric Oxide Biology and Pathobiology (2010)
  • Author(s): Hayashi T, Iguchi A.
  • Publisher: Elsevier Co. Ltd
• [Book] これからの老年医学 (2009)
  • Author(s): 林登志雄
  • Total Pages: 316
  • Publisher: 昆明医学中央出版/名大出版社
• [Patent(Industrial Property Rights)] シトルリンとNO (2009)
  • Inventor(s): 林登志雄, (他2名1番目)
  • Industrial Property Rights Holder: 林登志雄, (他2名1番目), 名古屋大学
  • Acquisition Date: 2009-10-10