The clinical significance of chronic kidney disease and its biomarker in the oldest old
| Project/Area Number |
21590775
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
General internal medicine (including Psychosomatic medicine)
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| Research Institution | Keio University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
HIROSE Nobuyoshi 慶應義塾大学, 医学部, 講師 (90142421)
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| Co-Investigator(Renkei-kenkyūsha) |
TAKAYAMA Michiyo 慶應義塾大学, 医学部, 助教 (60265824)
TAKAYAMA Midori 慶應義塾大学, 理工学部, 准教授 (10308025)
IINUMA Toshimitsu 日本大学, 歯学部, 講師 (10246902)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2011: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2009: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
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| Keywords | 超高齢者 / 慢性腎臓病 / 動脈硬化 / シスタチンC / 住民調査 / 方法論 / ビタミンD / 栄養疫学 / バイオマーカー / 前向きコホート研究 / 老年医学 |
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| Research Abstract |
To examine the clinical implication of chronic kidney disease(CKD) and its biomarker in the older adults, we established a cohort of 542 community-living seniors aged 85 years or older. In the cross-sectional analysis, we found that estimated gulomerular filtration ratios(eGFR) based on creatinine or cystatin C were associated with micro albuminuria, anemia, and parathyroid hormone ; however, only eGFR based on cystatin C was associated with carotid plaque, suggesting usefulness of cystatin C in detecting individuals at high risk for acardiovascular disease in this population.
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Report
(4 results)
Research Products
(43 results)
