Effects of early statin treatment on circulating inflammatory biomarkers and progressing stroke.
Project/Area Number |
21590778
|
Research Category |
Grant-in-Aid for Scientific Research (C)
|
Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
General internal medicine (including Psychosomatic medicine)
|
Research Institution | St. Marianna University School of Medicine |
Principal Investigator |
|
Research Collaborator |
HIRAYAMA Toshikazu 聖マリアンナ医科大学, 医学部, 講師
AKIYAMA Hisanao 聖マリアンナ医科大学, 医学部, 講師
SASAKI Naoshi 聖マリアンナ医科大学, 医学部, 助教
YAMADA Koji 聖マリアンナ医科大学, 医学部, 助教
|
Project Period (FY) |
2009 – 2011
|
Project Status |
Completed (Fiscal Year 2011)
|
Budget Amount *help |
¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Fiscal Year 2011: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2009: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
|
Keywords | 脳梗塞 / スタチン / インターロイキン / 進行性脳卒中 / サイトカイン / 高感度CRP / 進行性脳梗塞 |
Research Abstract |
A total of 146 ischemic stroke patients were enrolled and were divided into Statin Group(atorvastatin, 10 mg daily, initiated within 48 hrs after the onset) and Non-Statin Group(statin was not administered for 2 weeks). Early statin treatment significantly lowered the serum levels of IL-6(p=0.047) and frequency of neurological deterioration during 14 days after admission(p=0.035). Statin treatment within 48 hrs decreases IL-6 elevation and may protect against early neurological deterioration.
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Report
(4 results)
Research Products
(143 results)
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[Journal Article] Association between Inflammatory Biomarkers and Progression of Intracranial Large Artery Stenosis after Ischemic Stroke2011
Author(s)
Shimizu K, Shimomura K, Tokuyama Y, Sakurai K, Isahaya K, Takaishi S, Kato B, Usuki N, Shimizu T, Yamada K, Hasegawa Y
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Journal Title
Related Report
Peer Reviewed
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[Journal Article] 急性期脳血管障害患者の下肢深部静脈血栓症における臥位膝窩静脈径計測の意義2011
Author(s)
清水高弘, 下出淳子, 佐々木央我, 徳山承明, 伊佐早健司, 今井健, 萩原悠太, 鶴岡淳, 熱海千尋, 水上平祐, 榛沢和彦, 長谷川泰弘
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Journal Title
脳卒中
Volume: 33(3)
Pages: 319-325
NAID
Related Report
Peer Reviewed
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