| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2011: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2009: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Research Abstract |
We hypothesized in this study that "the decline of the vascularization factor due to the mitochondrial dysfunctional participated in renal damage by the aging". As a result of this study, we demonstrated that(1) the mitochondrial dysfunction by the accumulation of oxidative stress progress with aging in the kidney,(2) responsiveness of vascular endothelial growth factor expression for ischemia are decreased by mitochondrial dysfunction,(3) chronic ischemia are progressed by reduction of angiogenesis in the kidney, which caused progression of renal fibrosis.
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