Anti-aging on kidney : Elucidation of the mechanism and establishment of the integrated treatment strategy
| Project/Area Number |
21590780
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
General internal medicine (including Psychosomatic medicine)
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| Research Institution | Kawasaki Medical School |
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Principal Investigator |
TOMITA Naruya 川崎医科大学, 医学部, 准教授 (70314432)
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| Co-Investigator(Kenkyū-buntansha) |
KASHIHARA Naoki 川崎医科大学, 医学部, 教授 (10233701)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2011: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2009: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 腎臓学 / 加齢 / 血管新生 / ミトコンドリア / アンジオテンシンII / 酸化ストレス / 低酸素 / 虚血 / 腎臓 |
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| Research Abstract |
We hypothesized in this study that "the decline of the vascularization factor due to the mitochondrial dysfunctional participated in renal damage by the aging". As a result of this study, we demonstrated that(1) the mitochondrial dysfunction by the accumulation of oxidative stress progress with aging in the kidney,(2) responsiveness of vascular endothelial growth factor expression for ischemia are decreased by mitochondrial dysfunction,(3) chronic ischemia are progressed by reduction of angiogenesis in the kidney, which caused progression of renal fibrosis.
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Report
(4 results)
Research Products
(9 results)
