Investigation for the therapeutic monitoring methods using MEG and EEG
| Project/Area Number |
21590782
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
General internal medicine (including Psychosomatic medicine)
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| Research Institution | National Center for Geriatrics and Gerontology |
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Principal Investigator |
NAKAMURA Akinori 独立行政法人国立長寿医療研究センター, 脳機能画像診断開発部, 室長 (00237380)
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| Co-Investigator(Kenkyū-buntansha) |
YOSIYAMA Kenji 大阪大学, 大学院・医学系・研究科精神医学教室, 助教 (20426498)
BUNDOU Masahiko 独立行政法人国立長寿医療研究センター, 脳機能画像診断開発, 室長 (10426497)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 認知症 / 治療モニタリング / 脳磁図 / 脳波 / アルツハイマー型認知症 / 聴覚中潜時誘発反応 / 安静時自発脳波活動 / シータ波 / アルファ波 / 脳血流SPECT / コリン作動性ニューロン |
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| Research Abstract |
In order to establish non-invasive monitoring methods for dementia therapy, we investigated electrophysiological markers for Alzheimer disease(AD). We found patients with AD show ; 1) Slowing and reduced rhythmicity in alpha wave, 2) reduced functional connectivity between bilateral hemispheres, and 3) enhanced auditory middle latency responses. These changes are expected to be useful for the therapeutic monitoring for AD as functional biomarkers.
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Report
(4 results)
Research Products
(26 results)
