Carcinogenic effect of nitric oxide generated luminally at gastro-esophageal junction of human
Project/Area Number |
21590783
|
Research Category |
Grant-in-Aid for Scientific Research (C)
|
Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Gastroenterology
|
Research Institution | Tohoku University |
Principal Investigator |
|
Project Period (FY) |
2009 – 2011
|
Project Status |
Completed (Fiscal Year 2011)
|
Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2009: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
|
Keywords | 消化器内科学 / 食道・胃接合部癌 / バレット食道 / 一酸化窒素 / 食道・胃接合部 / 消化器学 |
Research Abstract |
At the human gastro-esophageal junction, nitric oxide (NO)is generated luminally during several hours after the ingestion of dietary nitrate. The present study demonstrated that exogenous luminal nitric oxide could be involved in the pathogenesis of reflux esophagitis and Barrett's esophagus, a precursor lesion of esophageal adenocarcinoma, and that the action caused by the NO presented the prominent gender difference. Since gender differences consistently exist in carcinogenesis at gastro-esophageal junction in human, understanding the mechanism by which action of NO on the esophageal epithelium could induce the gender difference should provide valuable information regarding the pathogenesis of esophageal adenocarcinoma.
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Report
(4 results)
Research Products
(18 results)