| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2009: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Research Abstract |
At the human gastro-esophageal junction, nitric oxide (NO)is generated luminally during several hours after the ingestion of dietary nitrate. The present study demonstrated that exogenous luminal nitric oxide could be involved in the pathogenesis of reflux esophagitis and Barrett's esophagus, a precursor lesion of esophageal adenocarcinoma, and that the action caused by the NO presented the prominent gender difference. Since gender differences consistently exist in carcinogenesis at gastro-esophageal junction in human, understanding the mechanism by which action of NO on the esophageal epithelium could induce the gender difference should provide valuable information regarding the pathogenesis of esophageal adenocarcinoma.
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