| Project/Area Number |
21590785
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Gastroenterology
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| Research Institution | Saitama University |
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Principal Investigator |
SAKAI Takafumi 埼玉大学, 大学院・理工学研究科, 教授 (40235114)
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| Co-Investigator(Kenkyū-buntansha) |
ADACHI Akihito 埼玉大学, 大学院・理工学研究科, 准教授 (20351588)
SAKATA Ichiro 埼玉大学, 大学院・理工学研究科, 助教 (80610831)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2009: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | 上部消化管学(食道、胃、十二指腸) / モチリン / スンクス / 空腹期収縮 / クローニング / 消化管運動 / 消化管ホルモン / 胃 / organ bath |
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| Research Abstract |
The suncus stomach and duodenum showed clear migrating phase III contractions(intervals of 80-150min)as found in humans and dogs. Exogenous motilin administration induced gastric phase III contractions, and motilin injection also increased the gastric motility index in a dose-dependent manner. Treatment of motilin antagonist inhibited the occurrence of phaseIII. Also, During the fasted state, cyclic MMC, consisting of phase I, II, and III were observed in both sham-operated and vagotomized suncus, but the duration and motility index(MI)of the phase II was significantly decreased in vagotomized suncus. In vagotomized suncus, feeing did not interrupt phase I of the MMC, and exogenous motilin induced strong phase III-like contractions as well as the fasted state.
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