A study of motilin-induced gastric migrating motor complex.-A novel approach for using newly established animal model-
| Project/Area Number |
21590785
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Gastroenterology
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| Research Institution | Saitama University |
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Principal Investigator |
SAKAI Takafumi 埼玉大学, 大学院・理工学研究科, 教授 (40235114)
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| Co-Investigator(Kenkyū-buntansha) |
ADACHI Akihito 埼玉大学, 大学院・理工学研究科, 准教授 (20351588)
SAKATA Ichiro 埼玉大学, 大学院・理工学研究科, 助教 (80610831)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2009: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | 上部消化管学(食道、胃、十二指腸) / モチリン / スンクス / 空腹期収縮 / クローニング / 消化管運動 / 消化管ホルモン / 胃 / organ bath |
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| Research Abstract |
The suncus stomach and duodenum showed clear migrating phase III contractions(intervals of 80-150min)as found in humans and dogs. Exogenous motilin administration induced gastric phase III contractions, and motilin injection also increased the gastric motility index in a dose-dependent manner. Treatment of motilin antagonist inhibited the occurrence of phaseIII. Also, During the fasted state, cyclic MMC, consisting of phase I, II, and III were observed in both sham-operated and vagotomized suncus, but the duration and motility index(MI)of the phase II was significantly decreased in vagotomized suncus. In vagotomized suncus, feeing did not interrupt phase I of the MMC, and exogenous motilin induced strong phase III-like contractions as well as the fasted state.
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Report
(4 results)
Research Products
(111 results)
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[Journal Article] Potentiation of ghrelin signaling attenuates cancer anorexia-cachexia and prolongs survival2011
Author(s)
Fujituka N, Asakawa A, Uezono Y, Minami K, Yamaguchi T, Niijima A, Yada T, Maejima Y, Sedbazar U, Sakai T, Hattori T, Kase Y, Inui A
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Journal Title
Translational Psychiatry
Volume: 1
Issue: 7
Pages: 23-23
DOI
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Peer Reviewed
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[Journal Article] Fragments of Genomic DNA Released by Injured Cells Activate Innate Immunity and Suppress Endocrine Function in the Thyroid2011
Author(s)
Kawashima A, Tanigawa K, Akama T, Wu H, Sue M, Yoshihara A, Ishido Y, Kobiyama K, Takeshita F, Ishii K, Hirano H, Kimura H, Sakai T, Ishii N, Suzuki K
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Journal Title
Endocrinology
Volume: 152(4)
Issue: 4
Pages: 1702-1712
DOI
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[Presentation] Motilin and ghrelin synergistically regulates migrating motor complex(MMC)of the gastrointestinal(GI)motility in the Suncus murinus(house musk shrew)2011
Author(s)
Mondal A, Xie Z, Miyano Y, Tsutsui C, Kawamoto Y, Aizawa S, Tanaka T, Oda S, Sakata I, Sakai T
Organizer
The 5th meeting of the Society of Gastrointestinal Intervention
Place of Presentation
Seoul, Korea
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[Presentation] Motilin and ghrelin synergistically regulates migrating motor complex (MMC) of the gastrointestinal (GI) motility in the Suncus murinus (house musk shrew)2011
Author(s)
Mondal A, Xie Z, Miyano Y,… Aizawa S, Tanaka T, Oda S, Sakata I, Sakai T
Organizer
The 5th meeting of the Society of Gastrointestinal Intervention, Seoul, Korea
Place of Presentation
Sheraton Grande Walkerhill, Soule, Korea
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[Presentation] Effects of endogenous ghrelin and motilin on the phase II and phase III of migrating motor complex in the free-moving house musk shrew (Suncus murinus)2011
Author(s)
Nishina K, Xie Z, Mondal A, Miyano Y, Kodaira Y, Sakata I, Sakai T
Organizer
Digestive Disease Week 2011, Chicago, USA
Place of Presentation
MCCORMICK PLACE, CHICAGO, IL
Related Report
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[Presentation] Ghrelin stimulates gastric contraction in a specific physiological condition in vivo and in vitro in the house musk shrew(Suncus murinus)2010
Author(s)
Xie Z, Sakahara S, Hoshino S, Ishida Y, Suzuki A, Koike K, Miyano Y, Kodaira Y, Takahashi T, Oda S, Sakai T
Organizer
a ghrelin-and motilin-producing laboratory animal. 2010 Digestive Disease Week
Place of Presentation
New Orleans
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[Presentation] Proposal of a new model animal, house musk shrew(Suncus murinus), for study of the ghrelin/motilin family-stimulatory effect of ghrelin on gastric contraction in IMC2009
Author(s)
K Koike, S Sakahara, Z Xie, Y Ishida, S Hoshino, C Tsutsui, H Kaiya, T Takahashi, S Oda, T Sakai
Organizer
2009 International Symposium on Ghrelin
Place of Presentation
東京
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[Presentation] Establishment of a new model animal, the house musk shrew(Suncus murinus), for study of precise mechanisms of motilin-induced gastrointestinal contractions in vivo and in vitro2009
Author(s)
S Sakahara, C Tsutsui, T Yanaka, Y Ishida, K Koike, Z Xie, A Suzuki, H Kaiya, T Takahashi, T Hirata, T Sakai
Organizer
Neurogastroenterology and Motility
Place of Presentation
Chicago
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