• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

A role of adiponectin in the pathogenesis of GERD and the development of adenocarcinoma from Barrett' s esophagus

Research Project

Project/Area Number 21590787
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Gastroenterology
Research InstitutionOsaka University

Principal Investigator

KENJI Watabe  大阪大学, 医学系・研究科, 助教 (50379244)

Co-Investigator(Kenkyū-buntansha) TSUTSUI Shusaku  大阪大学, 医学系・研究科, 助教 (10359846)
KISO Shinnichi  大阪大学, 医学系・研究科, 助教 (40335352)
YOSHIDA Yuichi  大阪大学, 医学系・研究科, 助教 (30457014)
TSUJII Masahiko  大阪大学, 医学系・研究科, 准教授 (40303937)
Co-Investigator(Renkei-kenkyūsha) KIHARA Shinji  大阪大学, 医学系・研究科, 教授 (20332736)
HAMASAKI Toshimitsu  大阪大学, 医学系・研究科, 准教授 (40379243)
Project Period (FY) 2009 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2009: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywords胃炎 / 食道炎 / 食道癌 / 肥満 / アディポネクチン / 胃潰瘍
Research Abstract

It has been recently demonstrated that obesity is related to the esophagitis and gastritis. Obesity is also reported to associate with adenocarcinoma arised from Barrett epithelium of the esophagus. In this study, we intended to clarify whether adiponectin(APN) secreted from adipose tissue is involved in these steps. 1) Clinical study. We analyzed medical records of participants of a routine health check-up examination. Lower serum level of APN is associated with an increased risk for erosive esophagitis as well as erosive gastritis. 2) Animal experimental study using APN knockout mice(APN-KO). We first failed to demonstrate the surgical model of reflux esophagitis due to technical reasons. We then examined the gastric injury induced by oral administration of ethanol(EtOH), and showed that severe gastric injury was induced in APN-KO accompanied by the impaired induction of PGE_2 in the injured stomach. 3) Cell culture study using rat gastric mucosal cells(RGM1). APN induced the expression level of PGE_2 in RGM1 cell treated with EtOH. RGM1 cells exhibited efficient wound repair accompanied by increased PGE_2 expression in the presence of adiponectin that is inhibited by coadministration with celecoxib, a COX-2 inhibitor. Collectively, APN showed protective effect in gastric injury induced by EtOH which may be partially mediated by the efficient wound repair of epithelial cells through increased PGE_2 expression.

Report

(4 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • 2009 Annual Research Report
  • Research Products

    (18 results)

All 2012 2011 2010 2009

All Journal Article (11 results) (of which Peer Reviewed: 10 results) Presentation (7 results)

  • [Journal Article] Protective role of adiponectin against ethanol-induced gastric injury in mice2012

    • Author(s)
      Yamamoto S, Watabe K, Araki H, Kamada Y, Kato M, Kizu T, Kiso S, Tsutsui S, Tsujii M, Kihara S, et al.
    • Journal Title

      Am J Physiol Gastrointest Liver Physiol

      Volume: 302(8)

    • NAID

      40019386509

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Is obesity a new risk factor for gastritis?2012

    • Author(s)
      Yamamoto S, Watabe K, Takehara T
    • Journal Title

      Digestion

      Volume: 85(2) Pages: 108-110

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Protective role of adiponectin against ethanol-induced gastric injury in mice2012

    • Author(s)
      Yamamoto S, Watabe K, et al
    • Journal Title

      Am J Physiol Gastrointest Liver Physiol

      Volume: (in press)

    • NAID

      40019386509

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Is obesity a new risk factor for gastritis?2012

    • Author(s)
      Yamamoto S, Watabe K, et al
    • Journal Title

      Digestion

      Volume: 85 Pages: 108-110

    • Related Report
      2011 Annual Research Report
  • [Journal Article] Association of low serum adiponectin levels with erosive esophagitis in men : an analysis of 2405 subjects undergoing physical check-ups2011

    • Author(s)
      Kato M, Watabe K, Hamasaki T, Umeda M, Furubayashi A, Kinoshita K, Kishida O, Fujimoto T, Yamada A, Tsukamoto Y, Yamamoto S, Kamada Y, Yoshida Y, Kiso S, Tsutsui S, Kihara S, et al.
    • Journal Title

      J Gastroenterol

      Volume: 46 Pages: 1361-1367

    • NAID

      10030295134

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Lower Serum Level of Adiponectin Is Associated with Increased Risk of Endoscopic Erosive Gastritis2011

    • Author(s)
      Yamamoto S, Watabe K, Tsutsui S, Kiso S, Hamasaki T, Kato M, Kamada Y, Yoshida Y, Kihara S, et al.
    • Journal Title

      Dig Dis Sci

      Volume: 56 Pages: 2354-2360

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Lack of adiponectin promotes formation of cholesterol gallstones in mice2010

    • Author(s)
      Ogiyama H, et al.
    • Journal Title

      Biochem Biophys Res Commun.

      Volume: 399 Pages: 352-358

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Adiponectin deficiency enhanced the severity of cerulein-induced chronic pancreatitis in mice.2010

    • Author(s)
      Yamada T, et al.
    • Journal Title

      J Gastroenterol.

      Volume: 45 Pages: 742-749

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Adiponectin deficiency enhanced the severity of cerulein-induced chronic pancreatitis in mice2010

    • Author(s)
      Yamada T, et al.
    • Journal Title

      J Gastroenterol (Epub ahead of print)

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Restoration of gut motility in Kit-deficient mice by bone marrow transplantation2009

    • Author(s)
      Ishii S, et al.
    • Journal Title

      J Gastroenterol 44

      Pages: 834-841

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A novel therapeutic strategy with anti-CD9 antibody in gastric cancers2009

    • Author(s)
      Nakamoto T, et al.
    • Journal Title

      J Gastroenterol 44

      Pages: 889-896

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Presentation] 胃粘膜傷害におけるアディポネクチンの防御的役割2011

    • Author(s)
      山本俊祐、渡部健二, など
    • Organizer
      Japan Digestive Disease Week 2011
    • Place of Presentation
      福岡
    • Year and Date
      2011-10-20
    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Presentation] 低アディポネクチン血症はびらん性胃炎のリスクファクターである2011

    • Author(s)
      山本俊祐、渡部健二, など
    • Organizer
      第97回日本消化器病学会総会
    • Place of Presentation
      東京
    • Year and Date
      2011-05-15
    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Presentation] Hypoadiponectinemia increases the presence of endoscopic erosive gastritis : An epidemiologic study of 2400 Japanese subjects2011

    • Author(s)
      Yamamoto S, Watabe K, et al.
    • Organizer
      Digestive Disease Week(American Gastroenterological Association)
    • Place of Presentation
      Chicago, USA
    • Year and Date
      2011-05-09
    • Related Report
      2011 Final Research Report
  • [Presentation] Hypoadiponectinemia increases the presence of endoscopic erosive gastritis : An epidemiologic study of 2400 Japanese subjects2011

    • Author(s)
      Yamamoto S, Watabe K, et al
    • Organizer
      Digestive Disease Week (American Gastroenterological Association)
    • Place of Presentation
      Chicago, USA
    • Year and Date
      2011-05-09
    • Related Report
      2011 Annual Research Report
  • [Presentation] Protective role of adiponectin against ethanol induced gastric injury in mice2011

    • Author(s)
      Yamamoto S, Watabe K, et al
    • Organizer
      Digestive Disease Week(American Gastroenterological Association)
    • Place of Presentation
      Chicago, USA
    • Year and Date
      2011-05-08
    • Related Report
      2011 Final Research Report
  • [Presentation] Protective role of adiponectin against ethanol induced gastric injury in mice2011

    • Author(s)
      Yamamoto S, Watabe K, et al
    • Organizer
      Digestive Disease Week (American Gastroenterological Association)
    • Place of Presentation
      Chicago, USA
    • Year and Date
      2011-05-08
    • Related Report
      2011 Annual Research Report
  • [Presentation] Association of hypoadiponectinemia with endoscopic esophagitis ; Analysis of 2405 subjects underwent health check-ups.2010

    • Author(s)
      Kato M, et al.
    • Organizer
      18^<th> United European Gastroenterology Week
    • Place of Presentation
      Barcelona, Spain
    • Related Report
      2010 Annual Research Report

URL: 

Published: 2009-04-01   Modified: 2016-04-21  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi