| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2009: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Research Abstract |
TRPV4 channels were mainly expressed in the esophageal epithelial cells of the basal and intermediate layers. Both 4α-PDD, a selective agonist for TRPV4, and hypoosmolar solution elevated the intracellular calcium concentration in a subset of the isolated esophageal cells. These calcium increases were inhibited by RuR, a TRPV4 antagonist, and were suppressed by extracellular protons. Direct exposure of TRPV4-expressing cells to gastric acid, as would occur in the case of GERD, could influence their cellular functions, possibly aggravating the disease state.
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