Transient receptor potential A1 mediates gastric distention-induced visceral pain in rats
| Project/Area Number |
21590798
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Gastroenterology
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| Research Institution | Hyogo Medical University |
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Principal Investigator |
TANAKA Junji 兵庫医科大学, 医学部, 助教 (90412022)
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| Co-Investigator(Kenkyū-buntansha) |
MIYOSHI Kan 兵庫医科大学, 医学部, 助教 (30454755)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2009: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 上部消化管学(食道、胃、十二指腸) / 内蔵痛 / TAPA1 / 後根神経節 / 迷走神経下神経節 / 内臓痛 / 胃 / 疼痛 / TRPA1 |
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| Research Abstract |
TRPA1 was predominantly expressed with sensory neuropeptides in dorsal root ganglion(DRG) and nodose ganglion(NG) neurons, and in nerve fibers in the rat stomach. Intrathecal injection of TRPA1 antisense attenuated the visceromotor response, and suppressed ERK1/2 activation in the DRG, but not NG, neurons produced by gastric distention(GD). Furthermore, intrathecal and intraperitoneal injections of the TRPA1 inhibitor HC-03003 suppressed the response to noxious GD. The activation of TRPA1 in DRG neurons by noxious GD may be involved in acute visceral pain.
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Report
(4 results)
Research Products
(15 results)
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[Journal Article] Sleep disturbances in a neuropathic pain-like condition in the mouse are associated with altered GABAergic transmission in the cingulate cortex2011
Author(s)
Narita M, Niikura K, Nanjo-Niikura K, Narita M, Furuya M, Yamashita A, Saeki M, Matsushima Y, Imai S, Shimizu T, Asato M, Kuzumaki N, Okutsu D, Miyoshi K, Suzuki M, Tsukiyama Y, Konno M, Yomiya K, Matoba M, Suzuki T.
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Journal Title
Pain
Volume: 152
Issue: 6
Pages: 1358-1372
DOI
Related Report
Peer Reviewed
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[Presentation] Activation of p38 MAPK through transient receptor potential A1 mediates gastric distention-in-duced visceral pain in rats2011
Author(s)
Kondo T, Oshima T, Yamasaki T, Okugawa T, Asano H, Toyoshima F, Sakurai J, Tanaka J, Tomita T, Fukui H, Hori K, Watari J, Matsumoto T, Noguchi K, Miwa H.
Organizer
19th United European Gastroenterology Week(UEGW2011)
Place of Presentation
Stockholm
Year and Date
2011-10-22
Related Report
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