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Transient receptor potential A1 mediates gastric distention-induced visceral pain in rats

Research Project

Project/Area Number 21590798
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Gastroenterology
Research InstitutionHyogo Medical University

Principal Investigator

TANAKA Junji  兵庫医科大学, 医学部, 助教 (90412022)

Co-Investigator(Kenkyū-buntansha) MIYOSHI Kan  兵庫医科大学, 医学部, 助教 (30454755)
Project Period (FY) 2009 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2009: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords上部消化管学(食道、胃、十二指腸) / 内蔵痛 / TAPA1 / 後根神経節 / 迷走神経下神経節 / 内臓痛 / 胃 / 疼痛 / TRPA1
Research Abstract

TRPA1 was predominantly expressed with sensory neuropeptides in dorsal root ganglion(DRG) and nodose ganglion(NG) neurons, and in nerve fibers in the rat stomach. Intrathecal injection of TRPA1 antisense attenuated the visceromotor response, and suppressed ERK1/2 activation in the DRG, but not NG, neurons produced by gastric distention(GD). Furthermore, intrathecal and intraperitoneal injections of the TRPA1 inhibitor HC-03003 suppressed the response to noxious GD. The activation of TRPA1 in DRG neurons by noxious GD may be involved in acute visceral pain.

Report

(4 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • 2009 Annual Research Report
  • Research Products

    (15 results)

All 2012 2011 2010 2009

All Journal Article (6 results) (of which Peer Reviewed: 6 results) Presentation (7 results) Book (2 results)

  • [Journal Article] Re-evaluation of the phenotypic changes in L4 dorsal root ganglion neurons after L5 spinal nerve ligation2012

    • Author(s)
      Fukuoka T, Yamanaka H, Kobayashi K, Okubo M, Miyoshi K, Dai Y, Noguchi K
    • Journal Title

      Pain

      Volume: 153 Issue: 1 Pages: 68-79

    • DOI

      10.1016/j.pain.2011.09.009

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Spinal 5-HT(3) receptor activation induces behavioral hypersensitivity via a neuronal-glial-neuronal signaling cascade2011

    • Author(s)
      Gu M, Miyoshi K, Dubner R, Guo W, Zou S, Ren K, Noguchi K, Wei F.
    • Journal Title

      J. Neurosci.

      Volume: 31 Issue: 36 Pages: 12823-12836

    • DOI

      10.1523/jneurosci.1564-11.2011

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Sleep disturbances in a neuropathic pain-like condition in the mouse are associated with altered GABAergic transmission in the cingulate cortex2011

    • Author(s)
      Narita M, Niikura K, Nanjo-Niikura K, Narita M, Furuya M, Yamashita A, Saeki M, Matsushima Y, Imai S, Shimizu T, Asato M, Kuzumaki N, Okutsu D, Miyoshi K, Suzuki M, Tsukiyama Y, Konno M, Yomiya K, Matoba M, Suzuki T.
    • Journal Title

      Pain

      Volume: 152 Issue: 6 Pages: 1358-1372

    • DOI

      10.1016/j.pain.2011.02.016

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Serotonin transporter gene polymorphism may be associated with functional dyspepsia in a Japanese population2011

    • Author(s)
      Toyoshima F, Oshima T, Nakajima S, Sakurai J, Tanaka J, Tomita T, Hori K, Matsumoto T, Miwa H.
    • Journal Title

      BMC Med Genet

      Volume: 12 Issue: 1 Pages: 12-88

    • DOI

      10.1186/1471-2350-12-88

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] The G-Protein beta 3 subunit 825 TT genotype is associated with epigastric pain syndrome-like dyspepsia2010

    • Author(s)
      Oshima T, et.al.
    • Journal Title

      BMC Med Genet

      Volume: 11 Pages: 13-13

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Transient receptor potential A1 mediates gastric distention-induced visceral pain in rats2009

    • Author(s)
      Kondo T., et.al.
    • Journal Title

      Gut 58

      Pages: 1342-1352

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Presentation] Activation of p38 MAPK through transient receptor potential A1 mediates gastric distention-in-duced visceral pain in rats2011

    • Author(s)
      Kondo T, Oshima T, Yamasaki T, Okugawa T, Asano H, Toyoshima F, Sakurai J, Tanaka J, Tomita T, Fukui H, Hori K, Watari J, Matsumoto T, Noguchi K, Miwa H.
    • Organizer
      19th United European Gastroenterology Week(UEGW2011)
    • Place of Presentation
      Stockholm
    • Year and Date
      2011-10-22
    • Related Report
      2011 Final Research Report
  • [Presentation] S-1/Lentinan+Paclitaxel併用療法により良好なQOLを維持し長期生存が得られている癌性腹水を伴う切除不能進行胃癌の1例2010

    • Author(s)
      田中淳二, 他14名
    • Organizer
      日本消化器病学会近畿支部第93回例会
    • Place of Presentation
      大阪
    • Year and Date
      2010-09-18
    • Related Report
      2010 Annual Research Report
  • [Presentation] Critical role for spinal IL-18/caspase-1 interaction in neuropathic pain development through its distinct regulation of interleukins2010

    • Author(s)
      Miyoshi K, Noguchi K.
    • Organizer
      World Congress on PAIN
    • Place of Presentation
      Montreal, Canada
    • Year and Date
      2010-08-30
    • Related Report
      2011 Final Research Report
  • [Presentation] 脊髄ミクログリアにおけるcaspase-1の発現増加は炎症性サイトカインの活性化を介して神経障害性疼痛の発症に関与する2009

    • Author(s)
      三好歓, 他1名
    • Organizer
      第2回日本運動器疼痛研究会
    • Place of Presentation
      東京
    • Year and Date
      2009-11-07
    • Related Report
      2009 Annual Research Report
  • [Presentation] Interleukin-1β converting enzyme(ICE)upregulation in spinal glial cells contributes to tactile allodynia after nerve injury2009

    • Author(s)
      Miyoshi K., et.al.
    • Organizer
      The 39th Annual Meeting of the Society for Neuroscience
    • Place of Presentation
      Chicago
    • Year and Date
      2009-10-20
    • Related Report
      2009 Annual Research Report
  • [Presentation] 脊髄マイクログリアにおけるinterleukin-1β converting enzyme(ICE)の発現増加とアロディニア2009

    • Author(s)
      三好歓, 他2名
    • Organizer
      第31回日本疼痛学会
    • Place of Presentation
      名古屋
    • Year and Date
      2009-07-17
    • Related Report
      2009 Annual Research Report
  • [Presentation] 脊髄マイクログリアにおけるICEの発現増加とアロディニア2009

    • Author(s)
      三好歓, 他2名
    • Organizer
      第7回整形外科痛みを語る会
    • Place of Presentation
      福岡
    • Year and Date
      2009-07-04
    • Related Report
      2009 Annual Research Report
  • [Book] 第6章6胃癌-消化器内科学2010

    • Author(s)
      田中淳二, 三輪洋人
    • Publisher
      シュプリンガ-ジャパン
    • Related Report
      2011 Final Research Report
  • [Book] 第vii章消化器系の症状・徴候と疾患3-消化関係の症状・徴候G.胃・十二指腸潰瘍-疾病と治療ii2010

    • Author(s)
      田中淳二
    • Publisher
      南江堂
    • Related Report
      2011 Final Research Report

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Published: 2009-04-01   Modified: 2016-04-21  

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