• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Development of a new endoscopic therapy using RNAi for intestinal fibrosis of Crohn's disease

Research Project

Project/Area Number 21590807
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Gastroenterology
Research InstitutionNiigata University

Principal Investigator

SUZUKI Kenji  新潟大学, 医歯学総合病院, 講師 (00303123)

Co-Investigator(Kenkyū-buntansha) 松田 康伸  新潟大学, 医歯学系, 准教授 (40334669)
山際 訓  新潟大学, 医歯学系, 助教 (10419327)
Project Period (FY) 2009 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2011: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2010: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2009: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
Keywords炎症性腸疾患 / クローン病 / 線維化 / siRNA / RNAi / 内視鏡 / 糖鎖 / 消化管狭窄 / RNA干渉 / 内視鏡的治療
Research Abstract

We have developed a new siRNA medicine, STNM-01 with Stelic Institute. In this project, we studied the therapeutic effects and the mechanism of endoscopic submucosal injection of the STNM-01 for the treatment of intestinal fibrosis using animal models. We have successfully developed a novel endoscopic injection therapy of STNM-01 for the treatment of intestinal fibrosis of Crohn's disease. Using this technique, we have started a phase I clinical trial for patients with Crohn's disease in Japan since January, 2012.

Report

(4 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • 2009 Annual Research Report
  • Research Products

    (37 results)

All 2012 2011 2010 2009

All Journal Article (35 results) (of which Peer Reviewed: 25 results) Presentation (2 results)

  • [Journal Article] Irsogladine maleate ameliorates inflammation and fibrosis in mice with chronic colitis induced by dextran sulfate sodium2012

    • Author(s)
      Yamaguchi H, Suzuki K, et al
    • Journal Title

      Medical Molecular Morphology

      Volume: (in press)

    • NAID

      10031073849

    • Related Report
      2011 Final Research Report
  • [Journal Article] Irsogladine maleate ameliorates inflammation and fibrosis in mice with chronic colitis induced by dextran sulfate sodium2012

    • Author(s)
      Yamaguchi H, et al.
    • Journal Title

      Medical Molecular Morphology

      Volume: (In press)

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Modulation of AT-1R/MAPK cascade by an olmesartan treatment attenuates diabetic nephropathy in streptozocin-induced diabetic mice2012

    • Author(s)
      Lakshmanan AP, et al.
    • Journal Title

      Mol Cell Endocrinol

      Volume: 348 Pages: 104-111

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A detailed investigation of accessibilities around target sites of siRNAs and miRNAs.2011

    • Author(s)
      Kiryu H, Terai G, Imamura O, Yoneyama H, Suzuki K, Asai K
    • Journal Title

      Bioinformatics

      Volume: 27 Pages: 1788-1797

    • Related Report
      2011 Final Research Report
  • [Journal Article] Analysis of intestinal fibrosis in chronic colitis in mice induced by dextran sulfate sodium2011

    • Author(s)
      uzuki K, et al.
    • Journal Title

      Pathol Int

      Volume: 61 Pages: 228-238

    • Related Report
      2011 Final Research Report
  • [Journal Article] Neurexin-1, a presynaptic adhesion molecule, localizes at the slit diaphragm of the glomerular podocyte in kidneys.2011

    • Author(s)
      Saito A, Miyauchi N, Hashimoto T, Karasawa T, Han GD, Kayaba M, Sumi T, Tomita M, Ikezumi Y, Suzuki K, Koitabashi Y, Shimizu F, Kawachi H
    • Journal Title

      Am J Physiol Regul Integr Comp Physiol

      Volume: 300 Pages: 340-348

    • Related Report
      2011 Final Research Report
  • [Journal Article] The primary site of the acrocephalic feature in Apert syndrome is a dwarf cranial base with accelerated chondrocytic differentiation due to aberrant activation of the FGFR2 signaling2011

    • Author(s)
      Nagata M, Nuckolls GH, Wang X. Shum L, Seki Y, Kawase T, Takahashi K, Nonaka K, Takahashi I, Noman AA, Suzuki K, Slavkin HC
    • Journal Title

      Bone

      Volume: 48 Pages: 847-856

    • Related Report
      2011 Final Research Report
  • [Journal Article] Curcumin ameliorates cardiac inflammation in rats with autoimmune myocarditis2011

    • Author(s)
      Mito S, Watanabe K, Harima M, Thandavaarayan RA, Veeraveedu PT, Sukumaran V, Suzuki K, Kodama M, Aizawa Y
    • Journal Title

      Biol Pharm Bull

      Volume: 34 Pages: 974-979

    • NAID

      130000738083

    • Related Report
      2011 Final Research Report
  • [Journal Article] Inhibition of cardiac oxidative and endoplasmic reticulum stress-mediated apoptosis by curcumin treatment contributes to pretection aganst acute myocarditis2011

    • Author(s)
      Mito AS, Thandavarayan RA, Ma M, Lakshmanan A, Suzui K, Kodama M, Watanabe K
    • Journal Title

      Free Radical Research

      Volume: 45 Pages: 1223-1231

    • Related Report
      2011 Final Research Report
  • [Journal Article] The primary site of acrocephalic feature in Apert syndrome is a dwarf cranial base with accelerated chondrocytic differenctiation due to aberrant activation of the PGFR2 signaling2011

    • Author(s)
      Nagata M, et al.
    • Journal Title

      Bone

      Volume: 48 Pages: 847-856

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A detailed investigation of accessibilities around target sites of siRNAs and miRNAs2011

    • Author(s)
      Kiryau H, et al.
    • Journal Title

      Bioinformatics

      Volume: 27 Pages: 1788-1797

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Attenuation of CHOP-mediated myocardial apoptosis in pressure-overloaaded dominant negative p38a mitogen-activated protein kinase2011

    • Author(s)
      Sari FR, et al.
    • Journal Title

      Cellular Physiology and Biochemistry

      Volume: 27 Pages: 487-496

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Curcumin ameliorates macrophage infiltration by inhibiting NF-kB activation and proinflammatory cytokines in streptozocin induced diabetic nephropathy2011

    • Author(s)
      Soetikono V, et al.
    • Journal Title

      Nutrition and Metabolism

      Volume: 8 Issue: 1 Pages: 35-35

    • DOI

      10.1186/1743-7075-8-35

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Regulation of inflammation and myocardial fibrosis in experimental autoimmune myocarditis2011

    • Author(s)
      Watanabe K, et al.
    • Journal Title

      Inflammation & Allergv-Drug Targets

      Volume: 10 Pages: 218-225

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Inhibition of cardiac oxidative and endoplasmic reticulum stress-mediated apoptosis by crucumin treatment contributes to protection against acute myocarditis2011

    • Author(s)
      Mito S, et al.
    • Journal Title

      Free Radical Research

      Volume: 45 Pages: 1223-1231

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Curcumin attenuates hyperglycemia-mediated. AMPK activation and oxidative stress in cerebrum of streptozocin-induced diabetic rat2011

    • Author(s)
      Lakshmanan AP, et al.
    • Journal Title

      Free Radiacl Research

      Volume: 45 Pages: 788-795

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Curcumin attenuates diabetic nephropathy by inhibiting PKC-a and PKC-b1 activity in streptozocin-induced type diabetic rats2011

    • Author(s)
      Soetikono V, et al.
    • Journal Title

      Mol Nutr Food Res

      Volume: 55 Pages: 1-11

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A Depletion of 14-3-3 protein exacerbates cardiac oxidative stress, inflammation and remodeling process via modulation of MAPK/NF-kB signaling pathways after streptozocin-induced diabetic mellitus2011

    • Author(s)
      Thandavarayan RA, et al.
    • Journal Title

      Cell Physiol Biochem

      Volume: 28 Pages: 911-922

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Analysis of intestinal fibrosis in chronic colitis in mice induced by dextran sulfate sodium.2011

    • Author(s)
      Kenji Suzuki, et al.
    • Journal Title

      Pathol Int.

      Volume: 61 Pages: 228-238

    • NAID

      10031185076

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Neurexin-1, a presynaptic adhesion molecule, localizes at the slit diaphragm of the glomerular podocyte in kidneys.2011

    • Author(s)
      Akira Saito, et al.
    • Journal Title

      Am J Physiol Regul Integr Comp Physiol

      Volume: 300

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Telmisartan ameliorates experimental autoimmune myocarditis Associated with inhibition of inflammation and oxidative stress.2011

    • Author(s)
      Vijayakumar Sukumaran
    • Journal Title

      Eur J Pharmacol

      Volume: 652 Pages: 126-135

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Telmisartan prevents the progression of renal injury in daunorubicin Rats with the alteration of angiotensin II and endothelin-1 receptor Expression associated with its PPAR-g agonist actions.2011

    • Author(s)
      Wawaimuli Arozal
    • Journal Title

      Toxicology

      Volume: 279 Pages: 91-99

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Olmesartan, an AT1 antagonist, attenuates oxidative stress, endoplasmic reticulum stress and cardiac inflammatory mediators in rats with Heart failure induced by experimental autoimmune myocarditis.2011

    • Author(s)
      Vijayakumar Sukumaran
    • Journal Title

      Int J Biol Sci

      Volume: 7 Pages: 154-167

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Carvedilol attenuates inflammatory-medicated cardiotoxicity in Daunorubicin-induced rats.2011

    • Author(s)
      Flori R Sari
    • Journal Title

      Pharmaceuticals

      Volume: 4 Pages: 551-566

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Carvedilol-afforded protection against daunorubicin-induced Cardiomyopathic rats in vivo : effects on cardiac fibrosis and hypertrophy.2011

    • Author(s)
      Wawaimuli Arozal
    • Journal Title

      ISRN Pharmacology

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Telmisartan ameliorates experimental autoimmune myocarditis associated with inhibition of inflammation and oxidative stress2010

    • Author(s)
      Sukumaran V, Watanabe K, Veeraveedu PT, Ma M, Gurusamay N, Rajavel V, Suzuki K, Ymaguchi K, Kodama M, Aizawa Y
    • Journal Title

      Eur J Pharmacol

      Volume: 652 Pages: 126-135

    • Related Report
      2011 Final Research Report
  • [Journal Article] Rectal administration of tranilast ameliorated acute colitis in mice through increased expression of heme oxygenase-12010

    • Author(s)
      Sun X, Suzuki K, et al.
    • Journal Title

      Pathol Int

      Volume: 60 Pages: 90-101

    • Related Report
      2011 Final Research Report
  • [Journal Article] Telmisaratan, an angiotensin-II receptor blocker ameliorates cardiac remodeling in rats with dilated cardiomyopathy2010

    • Author(s)
      Sukumaran V, Watanabe K, Veeraveedu PT, Thandavarayan RA, Gurusamy N, Ma M, Yagamaguchi K, Suzuki K, Kodama M, Aizawa Y
    • Journal Title

      Hypertension Res

      Volume: 33 Pages: 695-702

    • Related Report
      2011 Final Research Report
  • [Journal Article] Protective effect of carvedilol on daunorubicin-inducded cardiotoxicity and nephrotoxicity in rats.2010

    • Author(s)
      Wawaimuli Arozal
    • Journal Title

      Toxicology

      Volume: 274 Pages: 18-26

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Telmisartan, an angiotensin-II receptor blocker ameliorates cardiac Remodeling in rats with dilated cardiomyhopathy.2010

    • Author(s)
      Vijayakumar Sukumaran
    • Journal Title

      Hypertention research

      Volume: 33 Pages: 695-702

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Beneficial effects of angiotensin II receptor blocker, olmesartan, in limiting the cardiotoxic effect of daunorubicin in rats.2010

    • Author(s)
      Wawaimuli Arozal
    • Journal Title

      Free Radical Research

      Volume: 44 Pages: 1369-1377

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Beneficial effects of olmesartan, angiotensin II receptor type 1 antagonist, in rats with dilated cardiomyopathy.2010

    • Author(s)
      Vijayakumar Sukumaran
    • Journal Title

      Experimental Biology and Medicine

      Volume: 235 Pages: 1338-1346

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Rectal administration of tranilast ameliorated acute colitis in mice through increased expression of heme oxygenase-12010

    • Author(s)
      Xiaomei Sun
    • Journal Title

      Pathol Int. 60

      Pages: 93-101

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Tetaraspanin gene expression levels as potential biomarkers for malignancy of gingival squamous cell carcinoma2009

    • Author(s)
      Chizuru Hirano, et al.
    • Journal Title

      Int J Cancer 124

      Pages: 2911-2916

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effects of angiotensin receptor blocker on oxidative stress and cardio-renal function I streptozocin-induced diabetic rats2009

    • Author(s)
      Wawaimuli Arozat, et al.
    • Journal Title

      Biol.Pharm. Bull 32

      Pages: 1411-1416

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Presentation] 新薬はどのように開発するか?クローン病に対する世界初のsiRNA干渉薬開発の試み2011

    • Author(s)
      鈴木健司
    • Organizer
      第672回新潟医学会シンポジウム
    • Place of Presentation
      新潟大学医学部有壬記念館
    • Year and Date
      2011-11-19
    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Presentation] RNA干渉によるクローン病腸狭窄症治療薬開発2010

    • Author(s)
      鈴木健司
    • Organizer
      第96回日本消化器病学会総会
    • Place of Presentation
      新潟市朱鷺メッセ
    • Year and Date
      2010-04-23
    • Related Report
      2011 Final Research Report 2010 Annual Research Report

URL: 

Published: 2009-04-01   Modified: 2016-04-21  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi