| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2012: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2011: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Research Abstract |
The mucosal barrier function may contribute to the disease activity of inflammatory bowel disease (IBD). Previous studies showed that the intestinal alkaline phosphatase (IAP) maintains mucosal integrity of the gut. We tried to establish the experimental system which increases or decreases IAP on intestinal mucosa by using gene transfer system. It is known that TNBS colitis, which is one of mouse models of Crohn’s disease, is very difficult to induce colitis stably. However we succeeded in establishment of the system which makes the stable TNBS colitis by using continuous inhalation anesthesia with sevoflurane instead of conventional intraperitoneal anesthesia. We will further examine that the mechanism of IAP in mucosal barrier functions by using these models.
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