Therapeutic approaches targeting colonic myofibroblasts-derived IL-24 in inflammatory bowel disease.

• Project/Area Number: 21590809
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Gastroenterology
• Research Institution: Shiga University of Medical Science
• Principal Investigator: ANDO Akira 滋賀医科大学, 大学院・医学系研究科, 教授 (90252395)
• Project Period (FY): 2009 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2011: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2009: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: サイトカイン / 炎症性腸疾患 / 粘膜免疫 / IL-24 / 遺伝子治療 / IL-17

Research Abstract

we demonstrated that IL-24 expression is enhanced in the inflamed mucosa of active IBD patients. Colonic SEMFs-derived IL-24 appears to play a protective role in the pathophysiology of IBD via a stimulation of STAT3 activation in cells mediating the innate immune response.

Research Products

• [Journal Article] Development of a new immunoassay for the accurate determination of anti-infliximab antibodies in inflammatory bowel disease (2012)
  • Author(s): Imaeda H, Andoh A, Fujiyama Y
  • Journal Title: Journal of Gastroenterology Volume: 47 Issue: 2 Pages: 136-143
  • DOI: 10.1007/s00535-011-0474-y
  • Peer Reviewed
• [Journal Article] Faecal chitinase 3-like-1 : a novel biomarker of disease activity in paediatric inflammatory bowel disease (2011)
  • Author(s): Aomatsu T, Imaeda H, Matsumoto K, Kimura E, Yoden A, Tamai H, Fujiyama Y, Mizoguchi E, Andoh A.
  • Journal Title: Aliment Pharmacol Ther
• [Journal Article] Accuracy of genotyping using the TaqMan PCR assay for single nucleotide polymorphisms responsible for thiopurine sensitivity in Japanese patients with inflammatory bowel disease (2011)
  • Author(s): Osaki R, Imaeda H, Ban H, Aomatsu T, Bamba S, Tsujikawa T, Sasaki M, Fujiyama Y, Andoh A.
  • Journal Title: Exp. Ther. Med. Volume: 2(5) Pages: 783-786
• [Journal Article] Interleukin-33 suppresses Notch ligand expression and prevents goblet cell depletion in dextran sulfate sodium-induced colitis (2011)
  • Author(s): Imaeda H, Andoh A, Aomatsu T, Uchiyama K, Bamba S, Tsujikawa T, Naito Y, Fujiyama Y.
  • Journal Title: Int. J. Mol. Med. Volume: 28(4) Pages: 573-578
• [Journal Article] Faecal chitinase 3-like-1 : a novel biomarker of disease activity in paediatric inflammatory bowel disease (2011)
  • Author(s): Aomatsu T
  • Journal Title: Aliment Pharmacol Ther. Volume: 34 Issue: 8 Pages: 941-948
  • DOI: 10.1111/j.1365-2036.2011.04805.x
  • Peer Reviewed
• [Journal Article] Expression of IL-24, an activator of the JAK1/STAT3/SOCS3 cascade, is enhanced in inflammatory bowel disease (2009)
  • Author(s): Andoh A, Shioya M, Nishida A, Bamba S, Tsujikawa T, Kim-Mitsuyama S, Fujiyama Y.
  • Journal Title: Journal of Immunology 183 Pages: 687-695
  • Peer Reviewed
• [Journal Article] Recent advances in molecular approaches to gut microbiota in inflammatory bowel disease (2009)
  • Author(s): Andoh A, Benno Y, Kanauchi O, Fujiyama Y.
  • Journal Title: Curr Pharm Des. 15 Pages: 2066-2077
  • Peer Reviewed
• [Journal Article] Comparison of the fecal microbiota profiles between ulcerative colitis and Crohn's disease using terminal restriction fragment length polymorphism analysis.
  • Author(s): Akira Andoh
  • Journal Title: Journal of Gastroenterology Volume: (印刷中)
  • Peer Reviewed
• [Presentation] Molecular analysis of the diversity of gut microbiota of IBD (2010)
  • Author(s): Andoh A.
  • Organizer: 5^<th> Japan-Korea IBD symposium
  • Place of Presentation: Seoul
  • Year and Date: 2010-10-02
• [Presentation] 炎症性腸疾患の病態と腸内細菌の関わり (2010)
  • Author(s): 安藤朗
  • Organizer: 第13回日本臨床腸内細菌学会学術集会教育講演
  • Place of Presentation: 埼玉
  • Year and Date: 2010-09-11