| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2011: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2009: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Research Abstract |
Analysis of function of macrophages infected with cytomegalovirus(CMV). Macrophages, in which CMV was reactivated, strongly produced more pro-inflammatory cytokines in comparison with macrophages with no CMV reactivation. TGF-βdid not inhibit pro-inflammatory cytokine production from macrophages with CMV reactivation because Smad signal transduction was blocked in those cells.(2)Elucidation of mechanism of CMV infection in intestine of IBD. Gene expressions of PDGFR, etc., which could be entry site of CMV, were up-regulated in inflamed colonic mucosa in comparison with non-inflamed colonic mucosa. Interestingly, immunohistochemistry study revealed that CMV is mainly infected in mesenchymal cells of intestine.
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