Elucidation of the cellular transport system of immune-complex via the IgG-Fc receptor and its immune regulation mechanism
Project/Area Number |
21590811
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Gastroenterology
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Research Institution | Kobe University |
Principal Investigator |
|
Project Period (FY) |
2009 – 2011
|
Project Status |
Completed (Fiscal Year 2011)
|
Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2009: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
|
Keywords | FcRn / IgG / 胞内輸送システム / 免疫 / 病原微生物 / 細胞内輸送システム / IgG-Fc受容体 / 樹状細胞 |
Research Abstract |
In this study, I examined how FcγR and FcRn expressing on antigen presenting cells existing in the mucous membrane were concerned with the antigen presenting functions from the uptake of the antigen-IgG complex. As a result, the antigen-IgG complex was taken through FcγR in cell surface, and then was disintegrated in endosome, followed by being combined with FcRn. In addition, this study revealed the possibility that the antigen presenting ability was decreased by a loss of the FcRn functions. Therefore, the transport of IgG and the antigen-IgG complex, and FcγR expressing on antigen presenting cells existing in the mucous membrane may be associated with responsive mechanisms and mucous membrane immunoresponse of the host against the pathogenic microbes.
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Report
(4 results)
Research Products
(16 results)
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[Journal Article] Neonatal Fc receptor for IgG(FcRn) expressed in the gastric epithelium regulates bacterial infection in mice2012
Author(s)
Ben Suleiman Y, Yoshida M, Nishiumi S, Tanaka H, Mimura T, Nobutani K, Yamamoto K, Takenaka M, Aoganghua A, Miki I, Ota H, Takahashi S, Matsui H, Nakamura M, Blumberg RS, Azuma T
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Journal Title
Mucosal Immunol
Volume: 5(1)
Pages: 87-98
Related Report
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[Journal Article] Neonatal Fc receptor for IgG (FcRn) expressed in the gastric epithelium regulates bacterial infection in mice2012
Author(s)
Suleiyman YB, Yoshida M, Tanaka H, Nishiumi S, Mimura T, Nobutani K, Yamamoto K, Takenaka M, Ota H, Takahashi S, Matsui H, Nakamura M, Blumberg RS, Azuma T
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Journal Title
Mucosal Immunol
Volume: 5
Issue: 1
Pages: 87-98
DOI
Related Report
Peer Reviewed
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[Journal Article] The inhibitory effects of intravenous administration of rabbit immunoglobulin G on airway inflammation are dependent upon Fcγreceptor IIb on CD11c(+) dendritic cells in a murine model2010
Author(s)
Yamamoto M, Kobayashi K, Ishikawa Y, Nakata K, Funada Y, Kotani Y, Masuda A, Takai T, Azuma T, Yoshida M, Nishimura Y
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Journal Title
Clin Exp Immunol
Volume: 162(2)
Pages: 315-24
Related Report
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