Targeting anticancer drug delivery to colon cancer cells using a fucose-bound nanoparticle approach
Project/Area Number |
21590818
|
Research Category |
Grant-in-Aid for Scientific Research (C)
|
Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Gastroenterology
|
Research Institution | Sapporo Medical University |
Principal Investigator |
SATO Yasushi 札幌医科大学, 医学部, 講師 (80343383)
|
Co-Investigator(Kenkyū-buntansha) |
TAKIMOTO Rishu 札幌医科大学, 医学部, 講師 (10336399)
|
Project Period (FY) |
2009 – 2011
|
Project Status |
Completed (Fiscal Year 2011)
|
Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
|
Keywords | 癌 / 糖鎖 |
Research Abstract |
Increased expression of fucosyltransferases(FUTs) is common in colic adenocarcinoma cells5. FUTs are key enzymes accelerating malignant transformation through the fucosylation of different sialylated precursors, suggesting a crucial requirement for L-fucose by colic adenocarcinoma cells. We developed L-fucose-bound liposomes as vehicles for delivery of anticancer drugs specifically to these cells. We report that intravenously injected L-fucose-bound liposomes containing Cisplatin were successfully delivered to colic cancer cells, mediating efficient tumour growth inhibition in tumour-bearing mice.
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Report
(4 results)
Research Products
(5 results)