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Targeting anticancer drug delivery to colon cancer cells using a fucose-bound nanoparticle approach

Research Project

Project/Area Number 21590818
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Gastroenterology
Research InstitutionSapporo Medical University

Principal Investigator

SATO Yasushi  札幌医科大学, 医学部, 講師 (80343383)

Co-Investigator(Kenkyū-buntansha) TAKIMOTO Rishu  札幌医科大学, 医学部, 講師 (10336399)
Project Period (FY) 2009 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords癌 / 糖鎖
Research Abstract

Increased expression of fucosyltransferases(FUTs) is common in colic adenocarcinoma cells5. FUTs are key enzymes accelerating malignant transformation through the fucosylation of different sialylated precursors, suggesting a crucial requirement for L-fucose by colic adenocarcinoma cells. We developed L-fucose-bound liposomes as vehicles for delivery of anticancer drugs specifically to these cells. We report that intravenously injected L-fucose-bound liposomes containing Cisplatin were successfully delivered to colic cancer cells, mediating efficient tumour growth inhibition in tumour-bearing mice.

Report

(4 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • 2009 Annual Research Report
  • Research Products

    (5 results)

All 2010 2009 Other

All Journal Article (5 results) (of which Peer Reviewed: 5 results)

  • [Journal Article] Phase II study of S-1, docetaxel and cisplatin combination chemotherapy in patients with unresectable metastatic gastric cancer.2010

    • Author(s)
      Sato Y, Takimoto R., et al.
    • Journal Title

      Cancer Chemother Pharmacol.

      Volume: 66 Pages: 721-728

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Phase II study of S-1, docetaxel and cisplatin combination chemotherapy in patients with unresectable metastatic gastric cancer2009

    • Author(s)
      Sato Y, et al.
    • Journal Title

      Cancer Chemother Pharmacol.

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Suppressive effect of sulindac on branch duct-intraductal papillary mucinous neoplasms2009

    • Author(s)
      Hayashi T, et al.
    • Journal Title

      J Gastroenterol. 44

      Pages: 964-75

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Drug resistance is dramatically restored by hedgehog inhibitors in CD34+ leukemic cells.92009

    • Author(s)
      Kobune M, Sato Y, et al.
    • Journal Title

      Cancer Sci. 100(5)

      Pages: 948-55

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Targeting Anticancer Drug Delivery to Pancreatic Cancer Cells Using A Fucose-BoundNanoparticle Approach

    • Author(s)
      M Yoshida ; R Takimoto ; K Murase ; Y Sato ; M Hirakawa ; F Tamura ; T Sato ; S Iyama ; T Osuga ; K Miyanishi ; K Takada ; T Hayashi ; M Kobune ; J Kato
    • Journal Title

      PLoS ONE

      Volume: (In press)

    • Related Report
      2011 Final Research Report
    • Peer Reviewed

URL: 

Published: 2009-04-01   Modified: 2016-04-21  

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