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Elucidation of the phosphatidylinositol metabolism to control steatohepatitis and hepatocellular carcinoma

Research Project

Project/Area Number 21590823
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Gastroenterology
Research InstitutionAkita University

Principal Investigator

HORIE Yasuo  秋田大学, 大学院・医学系研究科, 講師 (30282164)

Co-Investigator(Kenkyū-buntansha) OHSHIMA Shigetoshi  秋田大学, 医学部, 講師 (50375268)
OHNISHI Hirohide  秋田大学, 大学院・医学系研究科, 教授 (00313023)
Co-Investigator(Renkei-kenkyūsha) SASAKI Takehiko  秋田大学, 大学院・医学系研究科, 教授 (50333365)
Project Period (FY) 2009 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywords肝臓学 / 肝腫瘍性病変 / 肝癌 / Akt2 / PPARγ / INPP4B / Pten / 脂肪性肝炎 / イノシトールリン脂質
Research Abstract

Deletion of phosphatidylinositol 3 kinase isozymes such as p110α, p110γ, and p110δ did not inhibit development of hepatic lesions in Pten KO mice. Inpp4 is a phosphatase which dephosphorylates PI(3, 4)P2 that is metabolite of PI(3, 4, 5)P3 and has the same function as PI(3, 4, 5)P3, a substrate of Pten. We made clear that Inpp4 or Akt2 and PPARγ, downstream molecules of Pten, played a critical role in development of hepatic lesions in Pten KO mice.

Report

(4 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • 2009 Annual Research Report
  • Research Products

    (3 results)

All 2012 2011

All Journal Article (2 results) (of which Peer Reviewed: 2 results) Presentation (1 results)

  • [Journal Article] PPARγ contributes to PKM2 and HK2 expression in fatty liver2012

    • Author(s)
      Panasyuki G, Horie Y, et al
    • Journal Title

      Nature Communication

      Volume: 3 Pages: 1-9

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] PPARγ contributes to PKM2 and HK2 expression in fatty liver2012

    • Author(s)
      Panasyuki, G, Horie Y, 16人中5番目, et al
    • Journal Title

      Nature Communication

      Volume: 3:672 Pages: 1-9

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Presentation] Steatohepatitis and hepatocellular carcinoma developed in hepatocyte-specific Pten-deficient mice2011

    • Author(s)
      Yasuo Horie, et al
    • Organizer
      The 9^<th> JSH Single Topic Conference (日本肝臓学会)
    • Place of Presentation
      Tokyo
    • Related Report
      2011 Final Research Report

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Published: 2009-04-01   Modified: 2016-04-21  

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