| Project/Area Number |
21590834
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Gastroenterology
|
|---|
| Research Institution | Niigata University |
|---|
Principal Investigator |
|
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| Co-Investigator(Kenkyū-buntansha) |
TAKAMURA Masaaki 新潟大学, 医歯学総合病院, 医員 (20422602)
MATSUDA Yasunobu 新潟大学, 医歯学系, 准教授 (40334669)
SATO Yoshinobu 新潟大学, 医歯学系, 講師 (20313538)
|
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| Project Period (FY) |
2009 – 2011
|
| Project Status |
Completed (Fiscal Year 2011)
|
| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2010: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2009: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
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| Keywords | 肝臓学 / 肝移植 / C型肝肝炎 / NK細胞 / 移植・再生医療 / C型肝炎 |
|---|
| Research Abstract |
The activating receptor natural killer group 2, member D(NKG2D) and its ligands play a crucial role in immune response to infections and tumors. Among the human NKG2D ligands, ULBP1 is prevalently expressed in hepatocellular carcinoma(HCC), but loss of its expression correlates with tumor progression and early recurrence. Although we could not find any significant changes in the gene expression profiles among the recurrent hepatitis C patients and chronic hepatitis C patients yet, our results suggest that the status of intrahepatic NK cell subsets and NK cell receptor ligand expressions might be associated with the rapid progression of recurrent hepatitis C infection.
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