Predictive marker for antiviral therapy using HCV genome analysis
| Project/Area Number |
21590836
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Gastroenterology
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| Research Institution | University of Yamanashi |
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Principal Investigator |
SAKAMOTO Minoru 山梨大学, 医学部・附属病院, 准教授 (60324191)
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| Co-Investigator(Kenkyū-buntansha) |
ENOMOTO Nobuyuki 山梨大学, 大学院・医学工学総合研究部, 教授 (20251530)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2009: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 肝臓学 / 臨床 / 内科 / ウイルス / ゲノム / 遺伝子 |
|---|
| Research Abstract |
We clarified the relation between HCV gene mutations and therapeutic effect of pegylated interferon(PEG-IFN) plus ribavirin(RBV) combination therapy for chronic hepatitis C. Number of mutations in the interferon sensitivity determining region(ISDR) or interferon/rivavirin resistance determining region(IRRDR) in HCV-5A, and amino acid substation of Core70 and Core 91 were correlated to therapeutic effect. Moreover, single nucleotide polymorphisms(SNPs) located near the IL28B gene were strongly associated with a response to PEG-IFN/RBV therapy in genotype 1 patients. In recent years, HCV protease inhibitor, Telaprevir(TVR) became available for HCV, these mutations were also important to predict therapeutic effect in triple therapy of PEG-IFN+RBV+TVR.
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Report
(4 results)
Research Products
(120 results)
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[Journal Article] Age and total ribavirin dose are independent predictors of relapse after interferon therapy in chronic hepatitis C revealed by data mining analysis2012
Author(s)
Kurosaki M, Hiramatsu N, Sakamoto M, Suzuki Y, Iwasaki M, Tamori A, Matsuura K, Sugauchi F, Sakamoto N, Yatsuhashi H, Izumi N.
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Journal Title
Antiviral Therapy
Volume: 17
Pages: 35-43
Related Report
Peer Reviewed
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[Journal Article] Analysis of viral amino acids sequences and the IL28B SNP influencing the development of hepatocellular carcinoma in chronic hepatitis C2012
Author(s)
Miura M, Maekawa S, Kadokura M, Sueki R, Komase K, Shindo H, Ohmori T, Kanayama A, Shindo K, Amemiya F, Nakayama Y, Kitamura T, Uetake T, Inoue T, Sakamoto M, Okada S, Enomoto N.
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Journal Title
Hepatol Int
Volume: 6
Pages: 386-396
Related Report
Peer Reviewed
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[Journal Article] Characterization of naturally occurring protease inhibitor-resistance mutations in genotype 1b hepatitis C virus patients2012
Author(s)
Shindo H, Maekawa S, Komase K, Sueki R, Miura M, Kadokura M, Shindo K, Amemiya F, Kitamura T, Nakayama Y, Inoue T, Sakamoto M, Okada S, Asahina Y, Izumi N, Honda M, Kaneko S, Enomoto N.
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Journal Title
Hepatol Int
Volume: 6
Pages: 386-396
Related Report
Peer Reviewed
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[Journal Article] Causes of thrombocytopenia in chronic hepatitis C viral infection2012
Author(s)
Osada M, Kaneko M, Sakamoto M, Endoh M, Takigawa K, Inoue-Suzuki K, Inoue O, Satoh K, Enomoto N, Yatomi Y, Ozaki Y.
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Journal Title
Clinical and Applied Thrombosis/Hemostasis
Volume: 18
Pages: 272-280
Related Report
Peer Reviewed
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[Journal Article] Data mining model using simple and readily available factors could identify patients at high risk for hepatocellular carcinoma in chronic hepatitis2012
Author(s)
Kurosaki M, Hiramatsu N, Sakamoto M, Suzuki Y, Iwasaki M, Tamori A, Matsuura K, Kakinuma S, Sugauchi F, Sakamoto N, Nakagawa M, Izumi N.
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Journal Title
Related Report
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[Journal Article] Pre-treatment prediction of response to pegylated-interferon plus ribavirin for chronic hepatitis C using genetic polymorfhism in IL28B and viral factors2011
Author(s)
Kurosaki M, Tanaka Y, Nishida N, Sakamoto N, Enomoto N, Honda M, Sugauchi M, Matsuura K, Sugauchi F, Asahina Y, Nakagawa M, Watanabe M, Sakamoto M, Maekawa S, Sakai A, Kaneko S, Ito K, Masaki N, Tokunaga K, Izumi N, Mizokami M.
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Journal Title
J Hepatol
Volume: 54
Pages: 439-448
Related Report
Peer Reviewed
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[Journal Article] Analysis of the complete open reading frame of hepatitis C virus genotype 2a infection reveals critical site influencing the response to peginterferon and ribavirin therapy2011
Author(s)
Kadokura M, Maekawa S, Sueki R, Miura M, Komase K, Shindo H, Amemiya F, Uetake T, Inoue T, Sakamoto M, Nakagawa M, Sakamoto N, Watanabe M, Enomoto N.
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Journal Title
Hepatol Int
Volume: 5(3)
Pages: 789-799
Related Report
Peer Reviewed
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[Journal Article] Analysis of the complete open reading frame of genotype 2b hepatitis C virus in association with the response to peginterferon and ribavirin therapy2011
Author(s)
Kadokura M, Maekawa S, Sueki R, Miura M, Komase K, Shindo H, Amemiya F, Uetake T, Inoue T, Sakamoto M, Nakagawa M, Sakamoto N, Watanabe M, Enomoto N.
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Journal Title
Related Report
Peer Reviewed
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