Combination chemoprevention of hepatocellular carcinoma with acyclic retinoid by targeting RXRαphosphorylation
Project/Area Number |
21590838
|
Research Category |
Grant-in-Aid for Scientific Research (C)
|
Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Gastroenterology
|
Research Institution | Gifu University |
Principal Investigator |
|
Co-Investigator(Kenkyū-buntansha) |
SHIMIZU Masahito 岐阜大学, 医学部附属病院, 助教 (90402198)
|
Project Period (FY) |
2009 – 2011
|
Project Status |
Completed (Fiscal Year 2011)
|
Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2009: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
|
Keywords | 非環式レチノイド / 核内受容体異常 / 併用化学発癌予防 / 肝細胞癌 |
Research Abstract |
Acyclic retinoid, a synthetic retinoid targeting RXR., prevented the recurrence of hepatocellular carcinoma(HCC) in hepatitis C virus-positive patients in a phase II/III clinical trial. This agent also inhibits obesity-related liver tumorigenesis and acts synergistically with valproic acid, GW4064, a FXR ligand, and branched-chain amino acids in suppressing growth in human HCC cells, indicating that "combination chemoprevention" with acyclic retinoid as the key drug has great potential to become an effective strategy for the prevention of liver carcinogenesis.
|
Report
(4 results)
Research Products
(71 results)
-
-
-
-
-
[Journal Article] Suppression of azoxymethane-induced colonic preneoplastic lesions in rats by 1-methyltryptophan, an inhibitor of indoleamine 2, 3-dioxygenase2012
Author(s)
Ogawa K, Hara T, Shimizu M, Ninomiya S, Nagano J, Sakai H, Hoshi M, Ito H, Tsurumi H, Saito K, Seishima M, Tanaka T, Moriwaki H
-
Journal Title
Cancer Sci
Volume: 103
Issue: 5
Pages: 951-958
DOI
Related Report
Peer Reviewed
-
-
-
-
[Journal Article] Preventive effects of(-)-epigallocatechin gallate on diethylnitrosamine-induced liver tumorigenesis in obese and diabetic C57BL/KsJ-db/db Mice2011
Author(s)
Shimizu M, Sakai H, Shirakami Y, Yasuda Y, Kubota M, Terakura D, Baba A, Ohno T, Hara Y, Tanaka T, Moriwaki H
-
Journal Title
Cancer Prev Res
Volume: 4
Pages: 396-403
Related Report
-
[Journal Article] Pitavastatin suppresses diethylnitrosamine-induced liver preneoplasms in male C57BL/KsJ-db/db obese mice2011
Author(s)
Shimizu M, Yasuda Y, Sakai H, Kubota M, Terakura D, Baba A, Ohno T, Kochi T, Tsurumi H, Tanaka T, Moriwaki H
-
Journal Title
BMC Cancer
Volume: 11
Pages: 281-281
Related Report
-
-
-
-
[Journal Article] Ultraviolet irradiation can induce evasion of colon cancer cells from stimulation of epidermal growth factor2011
Author(s)
Adachi S, Yasuda I, Nakashima M, Yamauchi T, Kawaguchi J, Shimizu M, Itani M, Nakamura M, Nishii Y, Yoshioka T, Hirose Y, Okano Y, Moriwaki H, Kozawa O
-
Journal Title
J Biol Chem
Volume: 286
Pages: 26178-26187
Related Report
-
-
[Journal Article] L-tryptophan-mediated enhancement of susceptibility to nonalcoholic fatty liver disease is dependent on the mammalian target of rapamycin2011
Author(s)
Osawa Y, Kanamori H, Seki E, Hoshi M, Ohtani H, Yasuda Y, Ito H, Suetsugu A, Nagaki M, Moriwaki H, Saito K, Seishima M
-
Journal Title
J Biol Chem
Volume: 286
Pages: 34800-34808
Related Report
-
[Journal Article] Acid sphingomyelinase regulates glucose and lipid metabolism in hepatocytes through AKT activation and AMP-activated protein kinase suppression2011
Author(s)
Osawa Y, Seki E, Kodama Y, Suetsugu A, Miura K, Adachi M, Ito H, Shiratori Y, Banno Y, Olefsky JM, Nagaki M, Moriwaki H, Brenner DA, Seishima M
-
Journal Title
FASEB J
Volume: 25
Pages: 1133-1144
Related Report
-
-
-
[Journal Article] Inhibition of Rho-associated coiled-coil containing protein kinase enhances the activation of epidermal growth factor receptor in pancreatic cancer cells2011
Author(s)
Nakashima M, Adachi S, Yasuda I, Yamauchi T, Kawaguchi J, Hanamatsu T, Yoshioka T, Okano Y, Hirose Y, Kozawa O, Moriwaki H
-
Journal Title
Mol Cancer
Volume: 10
Pages: 79-79
NAID
Related Report
-
[Journal Article] Phosphorylation status of heat shock protein 27 plays a key role in gemcitabine-induced apoptosis of pancreatic cancer cells2011
Author(s)
Nakashima M, Adachi S, Yasuda I, Yamauchi T, Kawaguchi J, Itani M, Yoshioka T, Matsushima-Nishiwaki R, Hirose Y, Kozawa O, Moriwaki H
-
Journal Title
Cancer Lett
Volume: 313
Pages: 218-225
Related Report
-
-
-
-
-
-
[Journal Article] Preventive effects of (-)-epigallocatechin gallate on diethylnitrosamine-induced liver tumorigenesis in obese and diabetic C57BL/KsJ-db/db Mice2011
Author(s)
Shimizu M, Sakai H, Shirakami Y, Yasuda Y, Kubota M, Terakura D, Baba A, Ohno T, Hara Y, Tanaka T, Moriwaki H
-
Journal Title
Cancer Prev Res
Volume: 4
Pages: 396-403
Related Report
Peer Reviewed
-
-
[Journal Article] Accumulation of refractory factors for pegylated interferon plus ribavirin therapy in older female patients with chronic hepatitis C2010
Author(s)
Chayama K, Hayes CN, Yoshioka K, Moriwaki H, Okanoue T, Sakisaka S, Takehara T, Oketani M, Toyota J, Izumi N, Hiasa Y, Matsumoto A, Nomura H, Seike M, Ueno Y, Yotsuyanagi H, Kumada H
-
Journal Title
Hepatol Res
Volume: 40
Pages: 1155-1167
NAID
Related Report
-
-
[Journal Article] Ability of IDO to attenuate liver injury in alpha-galactosylceramide-induced hepatitis model2010
Author(s)
Ito H, Hoshi M, Ohtaki H, Taguchi A, Ando K, Ishikawa T, Osawa Y, Hara A, Moriwaki H, Saito K, Seishima M
-
Journal Title
J Immunol
Volume: 185
Pages: 4554-4560
Related Report
-
-
-
-
[Journal Article] Insulin resistance raises the risk for recurrence of stage I hepatocellularcarcinoma after curative radiofrequency ablation in HCV-positive patiens : A prospective, case-series study2010
Author(s)
Imai K, Takai K, Nishigaki Y, Shimizu S, Naiki T, Hayashi H, Uematsu T, Sugihara J, Tomita E, Shimizu M, Nagaki M, Moriwaki H
-
Journal Title
Hepatol Res
Volume: 40
Pages: 376-382
Related Report
-
[Journal Article] The Study Group for the Standardization of Treatment of Viral Hepatitis Including Cirrhosis, Ministry of Health, Labor and Welfare of Japan. Guidelines for the treatment of chronic hepatitis and cirrhosis due to hepatitis B virus infection for the fiscal year 2008 in Japan2010
Author(s)
Kumada H, Okanoue T, Onji M, Moriwaki H, Izumi N, Tanaka E, Chayama K, Sakisaka S, Takehara T, Oketani M, Suzuki F, Toyota J, Nomura H, Yoshioka K, Seike M, Yotsuyanagi H, Ueno Y
-
Journal Title
Hepatol Res
Volume: 40
Pages: 1-7
Related Report
-
[Journal Article] The Study Group for the Standardization of Treatment of Viral Hepatitis Including Cirrhosis, Ministry of Health, Labour and Welfare of Japan. Guidelines for the treatment of chronic hepatitis and cirrhosis due to hepatitis C virus infection for the fiscal year 2008 in Japan2010
Author(s)
Kumada H, Okanoue T, Onji M, Moriwaki H, Izumi N, Tanaka E, Chayama K, Sakisaka S, Takehara T, Oketani M, Suzuki F, Toyota J, Nomura H, Yoshioka K, Seike M, Yotsuyanagi H, Ueno Y
-
Journal Title
Hepatol Res
Volume: 40
Pages: 8-13
Related Report
-
-
-
[Journal Article] Ability of IDO to attenuate liver injury in alpha-galactosylcerami de-induced hepatitis model.2010
Author(s)
Ito H, Hoshi M, Ohtaki H, Taguchi A, Ando K, Ishikawa T, Osawa Y , Hara A, Moriwaki H, Saito K, Seishima M.
-
Journal Title
J Immunol
Volume: 185
Pages: 4554-4560
Related Report
Peer Reviewed
-
-
-
-
[Journal Article] Insulin resistance raises the risk for recurrence of stage I hepato cellularcarcinoma after curative radiofrequency ablation in HCV-positive patiens : A prospective, case-series study.2010
Author(s)
Imai K, Takai K, Nishigaki Y, Shimizu S, Naiki T, Hayashi H, Uematsu T, Sugihara J, Tomita E, Shimizu M, Nagaki M, Moriwaki H.
-
Journal Title
Hepatol Res
Volume: 40
Pages: 376-382
Related Report
Peer Reviewed
-
[Journal Article] Guidelines for the treatment of chronic hepatitis and cirrhosis due to hepatitis B virus infection for the fiscal year 2008 in Japan.2010
Author(s)
Kumada H, Okanoue T, Onji M, Moriwaki H, Izumi N, Tanaka E, Chayama K, Sakisaka S, Takehara T, Oketani M, Suzuki F, Toyota J, Nomura H, Yoshioka K, Seike M, Yotsuyanagi H, Ueno Y
-
Journal Title
Hepatol Res
Volume: 40
Pages: 1-7
NAID
Related Report
Peer Reviewed
-
[Journal Article] Guidelines for the treatment of chronic hepatitis and cirrhosis due to hepatitis C virus infection for the fiscal year 2008 in Japan.2010
Author(s)
Kumada H, Okanoue T, Onji M, Moriwaki H, Izumi N, Tanaka E, Chayama K, Sakisaka S, Takehara T, Oketani M, Suzuki F, Toyota J, Nomura H, Yoshioka K, Seike M, Yotsuyanagi H, Ueno Y
-
Journal Title
Hepatol Res
Volume: 40
Pages: 8-13
NAID
Related Report
Peer Reviewed
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-