Immunological analysis of liver cancer stem cells and immunotherapy

• Project/Area Number: 21590841
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Gastroenterology
• Research Institution: Osaka University
• Principal Investigator: TATSUMI Tomohide 大阪大学, 大学院・医学系研究科, 助教 (20397699)
• Co-Investigator(Kenkyū-buntansha): TAKEHARA Tetsuo 大阪大学, 医学系・研究科, 准教授 (70335355)
• Project Period (FY): 2009 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2009: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: 肝癌 / 癌幹細胞 / 癌免疫

Research Abstract

We analyzed the immunological property of liver cancer stem cells(CSC). CD133+ CSC cells express higher MMP-2 and ADAM9 which resulted in increasing the ability of invasion, the production of VEGF and decreasing NK sensitivity of the liver CSC. FGF-2 enhances the NK sensitivity of HCC cells and serum FGF-2 levels decrease along the progression of chronic liver disease.α-fetoprotein inhibited the production of interleukin-12 of dendritic cells which resulted in the inhibition of activation of NK cells.

Research Products

• [Journal Article] Fibroblast growth factor-2 enhances NK sensitivity of hepatocellular carcinoma cells (2012)
  • Author(s): Tsunematsu H, Tatsumi T(2番目), Takehara T(11番目)(他8名)
  • Journal Title: Int J Cancer Volume: 130 Pages: 356-364
  • Peer Reviewed
• [Journal Article] Fibroblast growth factor-2 enhances NK sensitivity of hepatocellular carcinoma cells (2012)
  • Author(s): Tsunematsu H, Tatsumi T, et al
  • Journal Title: International Journal of Cancer Volume: 130 Issue: 2 Pages: 356-364
  • DOI: 10.1002/ijc.26003
  • Peer Reviewed
• [Journal Article] α-fetoprotein impairs activation of NK cells by inhibiting the function of dendritic cells (2011)
  • Author(s): Yamamoto M, Tatsumi T(2番目), Takehara T(10番目)(他7名)
  • Journal Title: Clin Exp Immunol Volume: 165 Pages: 211-219
  • Peer Reviewed
• [Journal Article] Delayed-onset caspase-dependent massive hepatocyte apoptosis upon Fas activation in Bak/ Bax-deficient mice (2011)
  • Author(s): Hikita H, Takehara T(2番目), Tatsumi T(8番目)(他12名)
  • Journal Title: Hepatology Pages: 240-251
  • Peer Reviewed
• [Journal Article] Alternations in microRNA expression profile in HCV-infected hepatoma cells : Involvement of miR-491 in regulation of HCV replication via PI3 kinase/ Akt pathway (2011)
  • Author(s): Ishida H, Tatsumi T(2番目), Takehara T(11番目)(他8名)
  • Journal Title: Biochem Biophys Res Commun Volume: 412 Pages: 92-97
  • Peer Reviewed
• [Journal Article] Increases in p53 expression induce CTGF synthesis by mouse and human hepatocytes and result in liver fibrosis in mice (2011)
  • Author(s): Kodama T, Takehara T(2番目), Tatsumi T(10番目)(他18名)
  • Journal Title: J Clin Invest Volume: 121 Pages: 3343-3356
  • Peer Reviewed
• [Journal Article] BH3-only activator proteins Bid and Bim are dispensable for Bak/ Bax-dependent thrombocyte apoptosis induced by Bcl-xL deficiency (2011)
  • Author(s): Kodama T, Takehara T(2番目), Tatsumi T(9番目)(他10名)
  • Journal Title: J Bio Chem Volume: 286(16) Pages: 13905-13913
  • Peer Reviewed
• [Journal Article] Involvement of STAT3-regulated hepatic soluble factors in attenuation of stellate cell activity and liver fibrogenesis in mice (2011)
  • Author(s): Shigekawa M, Takehara T(2番目), Tatsumi T(9番目)(他10名)
  • Journal Title: Biochem Biophys Res Commun Volume: 406 Pages: 614-620
  • Peer Reviewed
• [Journal Article] α-galactosylceramide activates antitumor immunity against liver tumor (2011)
  • Author(s): Tatsumi T(1番目), Takehara T(2番目)(他7名)
  • Journal Title: Hepatol Res Volume: 41 Pages: 160-169
  • Peer Reviewed
• [Journal Article] Amino acid substitution in the core protein has no impact on relapse in hepatitis C genotype 1 patients treated with peginterferon and ribavirin (2011)
  • Author(s): Inoue Y, Tatsumi T(14番目), Takehara T(18番目)(他16名)
  • Journal Title: J Med Virol Volume: 83 Pages: 419-427
  • Peer Reviewed
• [Journal Article] Hepatitis C virus-specific CD8+ T cell frequencies are associated with the responses of pegylated interferon-αand ribavirin combination therapy in patients with chronic hepatitis C virus infection (2011)
  • Author(s): Tatsumi T(1番目), Takehara T(2番目)(他8名)
  • Journal Title: Hepatol Res Volume: 41 Pages: 30-38
  • Peer Reviewed
• [Journal Article] Indications and limitations for aged patients with chronic hepatitis C in pegylated interferon alfa-2b plus ribavirin combination therapy (2011)
  • Author(s): Oze T, Tatsumi T, et al
  • Journal Title: Journal of Hepatology Volume: 121 Pages: 3343-3356
  • Peer Reviewed
• [Journal Article] Hepatitis C virus-specific CD8+ T cell frequencies are associated with the responses of pegylated interferon-α and ribavirin combination therapy in patients with chronic hepatitis C virus infection (2011)
  • Author(s): Tatsumi T, et al
  • Journal Title: Hepatology Research Volume: 41 Issue: 1 Pages: 30-38
  • DOI: 10.1111/j.1872-034x.2010.00734.x
  • Peer Reviewed
• [Journal Article] Amino acid substitution in the core protein has no impact on relapse in hepatitis C genotype 1 patients treated with peginterferon and ribavirin (2011)
  • Author(s): Inoue Y, Tatsumi T, et al
  • Journal Title: Journal of Medical Virology Volume: 83 Issue: 3 Pages: 419-427
  • DOI: 10.1002/jmv.21975
  • Peer Reviewed
• [Journal Article] α-galactosylceramide activates antitumor immunity against liver tumor (2011)
  • Author(s): Tatsumi T, et al
  • Journal Title: Hepatology Research Volume: 41 Issue: 2 Pages: 160-169
  • DOI: 10.1111/j.1872-034x.2010.00743.x
  • Peer Reviewed
• [Journal Article] Involvement of STAT3-regulated hepatic soluble factors in attenuation of stellate cell activity and liver fibrogenesis in mice (2011)
  • Author(s): Shigekawa M, Tatsumi T, et al
  • Journal Title: Biochemical and Biophysical Research Communications Volume: 406 Pages: 614-620
  • Peer Reviewed
• [Journal Article] BH3-only activator proteins Bid and Bim are dispensable for Bak/Bax-dependent thrombocyte apoptosis induced by Bcl-xL deficiency (2011)
  • Author(s): Kodama T, Tatsumi T, et al
  • Journal Title: The Journal of Biological Chemistry Volume: 286 Pages: 13905-13913
  • Peer Reviewed
• [Journal Article] Efficacy of re-treatment with pegylated interferon plus ribavirin combination therpy for patients with chronic hepatitis C in Japan (2011)
  • Author(s): Oze T, Tatsumi T, et al
  • Journal Title: Journal of Gastroenterology Volume: 46 Issue: 8 Pages: 1031-1037
  • DOI: 10.1007/s00535-011-0409-7
  • Peer Reviewed
• [Journal Article] Increases in p53 expression induce CTGF synthesis by mouse and human hepatocytes and result in liver fibrosis in mice (2011)
  • Author(s): Kodama T, Tatsumi T, et al
  • Journal Title: The Journal of Clinical Investigation Volume: 121 Pages: 2243-3356
  • Peer Reviewed
• [Journal Article] Differential alteration of CD56^<bright> and CD56^<dim> natural killer cells in frequency, phenotype and cytokine response in chronic hepatitis C virus infection (2011)
  • Author(s): Miyagi T, Tatsumi T, et al
  • Journal Title: Journal of Gastroenterology Volume: 46 Issue: 8 Pages: 1020-1030
  • DOI: 10.1007/s00535-011-0408-8
  • NAID: 10029563284
  • Peer Reviewed
• [Journal Article] Delayed-onset caspase-dependent massive hepatocyte apoptosis upon Fasactivation in Bak/Bax-deficient mice (2011)
  • Author(s): Hikita, H.
  • Journal Title: Hepatology Volume: VOL. 54 Issue: 1 Pages: 240-251
  • DOI: 10.1002/hep.24305
  • Peer Reviewed
• [Journal Article] α-fetoprotein impairs activation of NK cells by inhibiting the function of dendritic cells (2011)
  • Author(s): Yamamoto M, Tatsumi T, et al
  • Journal Title: Clinical and Experimental Immunology Volume: 165 Issue: 2 Pages: 211-219
  • DOI: 10.1111/j.1365-2249.2011.04421.x
  • Peer Reviewed
• [Journal Article] Alternations in microRNA expression profile in HCV-infected hepatoma cells : Involvement of miR-491 in regulation of HCV replication via PI3 kinase/Akt pathway (2011)
  • Author(s): Ishida H, Tatsumi T, et al
  • Journal Title: Biochemical and Biophysical Research Communications Volume: 412 Pages: 92-97
  • Peer Reviewed
• [Journal Article] The Bcl-xL inhibitor, ABT-737, efficiently induces apoptosis and suppresses growth of hepatoma cells in combination with sorafenib (2010)
  • Author(s): Hikita H, Takehara T(2番目), Tatsumi T(9番目)(他11名)
  • Journal Title: Hepatology Volume: 52 Pages: 1310-1321
  • NAID: 40018998703
  • Peer Reviewed
• [Journal Article] Absence of invariant natural killer T cells deteriorates liver inflammation and fibrosis in mice fed high-fat diet (2010)
  • Author(s): Miyagi T, Takehara T(2番目), Tatsumi T(10番目)(他11名)
  • Journal Title: J Gastroenterol Volume: 45 Pages: 1247-1254
  • NAID: 10027700169
  • Peer Reviewed
• [Journal Article] Altered interferon-α-signaling in natural killer cells from patients with chronic hepatitis C virus infection (2010)
  • Author(s): Miyagi T, Takehara T(2番目), Tatsumi T(7番目)(他7名)
  • Journal Title: J Hepatol Volume: 53 Pages: 424-430
  • Peer Reviewed
• [Journal Article] Alterations in hepatitis B virus nucleotide sequences in a chronic virus carrier from immunotolerant to immunoactive phase (2010)
  • Author(s): Ohkawa K, Takehara T(2番目), Tatsumi T(3番目), (他8名)
  • Journal Title: Biochemi Biophys Res Commun Volume: 394 Pages: 574-580
  • Peer Reviewed
• [Journal Article] Fatal exacerbation of type B chronic hepatitis trigged by changes in relaxed circular viral DNA synthesis and virion secretion (2010)
  • Author(s): Ohkawa K, Takehara T(2番目), Tatsumi T(14番目)(他13名)
  • Journal Title: Biochemi Biophys Res Commun Volume: 394 Pages: 87-93
  • Peer Reviewed
• [Journal Article] Sorafenib inhibits the shedding of major histocomaptibility complex class I-related chain A on hepatocellular cacrcinoma cells by down-regulating a disintegrin and metalloproteinase 9 (2010)
  • Author(s): Kohga K, Takehara T(2番目), Tatsumi T(3番目)(他4名)
  • Journal Title: Hepatology Volume: 51 Pages: 1264-1273
  • Peer Reviewed
• [Journal Article] Thrombocytopenia exacerbates cholestasis-induced liver fibrosis in mice (2010)
  • Author(s): Kodama T, Takehara T(2番目), Tatsumi T(8番目)(他11名)
  • Journal Title: Gastroenterology Volume: 138 Pages: 2487-2498
  • NAID: 40017376760
  • Peer Reviewed
• [Journal Article] Expression of CD133 confers malignant potential by regulating metalloproteinases in human hepatocellular carcinoma (2010)
  • Author(s): Kohga K, Tatsumi T(2番目), Takehara T(3番目)(他6名)
  • Journal Title: J Hepatol Volume: 52 Pages: 872-879
  • Peer Reviewed
• [Journal Article] EphA2-derived peptide vaccine with amphiphilic poly(γ-gulutamic acid) nanoparticles elicits antitumor effect against mouse liver tumor (2010)
  • Author(s): Yamaguchi S, Tatsumi T(2番目), Takehara T(3番目)(他9名)
  • Journal Title: EphA2-derived peptide vaccine with amphiphilic poly(γ-gulutamic acid) nanoparticles elicits antitumor effect against mouse liver tumor Volume: 59 Pages: 759-767
  • Peer Reviewed
• [Journal Article] STAT3 signaling within hepatocyte is required for anemia of inflammation in vivo (2010)
  • Author(s): Sakamori R, Takehara T(2番目), Tatsumi T(3番目)(他5名)
  • Journal Title: J Gastroenterology Volume: 45 Pages: 244-248
  • NAID: 10027214771
  • Peer Reviewed
• [Journal Article] The let7 family of microRNAs inhibits Bcl-xL expression and potentiates sorafenib-induced apoptosis in human hepatocellular carcinoma (2010)
  • Author(s): Shimizu S, Takehara T(2番目), Tatsumi T(7番目)(他10名)
  • Journal Title: J Hepatol Volume: 52 Pages: 698-704
  • Peer Reviewed
• [Journal Article] The let7 family of microRNAs inhibits Bcl-xL expression and potentiates sorafenib-induced apoptosis in human hepatocellular carcinoma (2010)
  • Author(s): Shimizu S, Tatsumi T, et al.
  • Journal Title: Journal of Hepatology Volume: 52 Pages: 698-704
  • Peer Reviewed
• [Journal Article] Natural Killer cell is a major producer of interferon γ that is critical for the IL-12-induced antitumor effect in mice (2010)
  • Author(s): Uemura A, Tatsumi T, et al.
  • Journal Title: Cancer Immunology, Immunotherapy Volume: 59 Pages: 453-463
  • Peer Reviewed
• [Journal Article] STAT3 signaling within hepatocyte is required for anemia of inflammation in vivo (2010)
  • Author(s): Sakamori R, Tatsumi T, et al.
  • Journal Title: Journal of Gastroenterology Volume: 45 Pages: 244-248
  • NAID: 10027214771
  • Peer Reviewed
• [Journal Article] EphA2-derived peptide vaccine with amphiphilic poly(γ-gulutamic acid) nanoparticles elicits antitumor effect against mouse liver tumor (2010)
  • Author(s): Yamaguchi, Tatsumi T, et al.
  • Journal Title: Cancer Immunology, Immunotherapy Volume: 59 Pages: 759-767
  • Peer Reviewed
• [Journal Article] Expression of CD133 confers malignant potential by regulating metalloproteinases in human hepatocellular carcinoma (2010)
  • Author(s): Kohga K, Tatsumi T, et al.
  • Journal Title: Journal of Hepatology Volume: 52 Pages: 872-879
  • Peer Reviewed
• [Journal Article] Sorafenib inhibits the shedding of MICA on hepatocellular cacrcinoma cell by downregulating ADAM9 (2010)
  • Author(s): Kohga K, Tatsumi T, et al.
  • Journal Title: Hepatology Volume: 51 Pages: 1264-1273
  • Peer Reviewed
• [Journal Article] Fatal exacerbation of type B chronic hepatitis trigged by changes in relaxed circular viral DNA synthesis and virion secretion (2010)
  • Author(s): Ohkawa K, Tatsumi T, et al.
  • Journal Title: Biochemical and Biophysical Research Communications Volume: 394 Pages: 87-93
  • Peer Reviewed
• [Journal Article] Altered interferon-α-signaling in natural killer cells from patients with chronic hepatitis C virus infection (2010)
  • Author(s): Miyagi T, Tatsumi T, et al.
  • Journal Title: Journal of Hepatology Volume: 53 Pages: 424-430
  • Peer Reviewed
• [Journal Article] Absence of invariant natural killer T cells deteriorates liver inflammation and fibrosis in mice fed high-fat diet (2010)
  • Author(s): Miyagi T, Tatsumi T, et al.
  • Journal Title: Journal of Gastroenterology Volume: 45 Pages: 1247-1254
  • NAID: 10027700169
  • Peer Reviewed
• [Journal Article] The Bcl-xL inhibitor, ABTT-737, efficiently induced apoptosis suppresses growth of hepatoma cells in combination with sorafenib (2010)
  • Author(s): Hikita H, Tatsumi T, et al.
  • Journal Title: Hepatology Volume: 52 Pages: 1310-1321
  • Peer Reviewed
• [Journal Article] Anticancer chemotherapy inhibits MHC Class I-related chain A ectodomain shedding by downregulating ADAM10 expression in hepatocellular carcinoma (2009)
  • Author(s): Kohga K, Takehara T(2番目), Tatsuumi T(3番目)(他6名)
  • Journal Title: Cancer Res Volume: 69 Pages: 8050-8057
  • Peer Reviewed
• [Journal Article] BH3-only protein Bid participates in the Bcl-2 network in healthy liver cells (2009)
  • Author(s): Hikita H, Takehara T(2番目), Tatsumi T(7番目)(他12名)
  • Journal Title: Hepatology Volume: 50 Pages: 1972-1980
  • Peer Reviewed
• [Journal Article] Mcl-1 and Bcl-xL cooperatively maintain integrity of hepatocytes in developing and adult liver (2009)
  • Author(s): Hikita H, Takehara T(2番目), Tatsumi T(14番目)(他12名)
  • Journal Title: Hepatology Volume: 50 Pages: 1217-1226
  • Peer Reviewed
• [Journal Article] Activated liver dendritic cells generates strong acquired immunity inα-galactosylceramide treatment (2009)
  • Author(s): Sasakawa A, Tatsumi T(2番目), Takehara T(3番目)(他6名)
  • Journal Title: J Hepatol Volume: 50 Pages: 1155-1162
  • Peer Reviewed
• [Journal Article] Activated liver dendritic cells generates strong acquired immunity in α-galactosylc eramide treatment (2009)
  • Author(s): Sasakawa A, Tatsumi T, et al.
  • Journal Title: Journal of Hepatology 50 Pages: 1155-1162
  • Peer Reviewed
• [Journal Article] Pegylated interferon alpha-2b (Peg-IFN alpha-2b) affects early virologic response dose-dependently in patients with chronic hepatitis C genotype 1 during treatment with Peg-IFN alpha-2b plus ribavirin (2009)
  • Author(s): Oze T, Tatsumi T, et al.
  • Journal Title: Journal of Viral Hepatitis 16 Pages: 578-585
  • Peer Reviewed
• [Journal Article] Mutations associated with therapeutic efficacy of Adefovir dipivoxil added to Lamivudine in patients resistant to Lamivudine with type B chronic hepatitis (2009)
  • Author(s): Ohkawa K, Tatsumi T, et al
  • Journal Title: Journal of Medical Virology 81 Pages: 798-806
  • Peer Reviewed
• [Journal Article] Ribavirin dose reduction raises relapse rate dose-dependently in genotype 1 patients with hepatitis C responding to pegylated interferon alpha-2b plus ribavirin (2009)
  • Author(s): Hiramatsu N, Tatsumi T, et al
  • Journal Title: Journal of Viral Hepatitis 16 Pages: 586-594
  • Peer Reviewed
• [Journal Article] Mcl-1 and Bcl-xL cooperatively maintain integrity of hepatocytes in developing and adult liver (2009)
  • Author(s): Hikita H, Tatsumi T, et al
  • Journal Title: Hepatology 50 Pages: 1217-1226
  • Peer Reviewed
• [Journal Article] BH3-only protein Bid participates in the Bcl-2 network in healthy liver cells (2009)
  • Author(s): Hikita H, Tatsumi T, et al
  • Journal Title: Hepatology 50 Pages: 1972-1980
  • Peer Reviewed
• [Journal Article] Anti-cancer chemotherapy inhibits MICA ectodomain shedding by downregulating ADAM10 expression in hepatocellular carcinoma (2009)
  • Author(s): Kohga K, Tatsumi T, et al
  • Journal Title: Camcer Research 69 Pages: 8050-8057
  • Peer Reviewed
• [Presentation] Multi-kinase inhibitor sorafenib induces autophagy which confers anti-cancer drug resistance to human hepatoma cells (2011)
  • Author(s): Shimizu S, Tatsumi T, Takehara T(他9名)
  • Organizer: 第62回米国肝臓学会
  • Place of Presentation: 米国サンフランシスコ
  • Year and Date: 2011-11-08
• [Presentation] Interferon-αsuppresses hepatitis B virus enhancer II activity via PKC pathway (2011)
  • Author(s): Nawa T, Tatsumi T, Takehara T(他9名)
  • Organizer: 第62回米国肝臓学会
  • Place of Presentation: 米国サンフランシスコ
  • Year and Date: 2011-11-07
• [Presentation] STAT5 plays a crucial role in hepatic lipid metabolism through regulation of CD36 expression (2011)
  • Author(s): 法水淳、巽智秀, 他
  • Organizer: 第62回米国肝臓学会
  • Place of Presentation: 米国サンフランシスコ市
  • Year and Date: 2011-11-07
• [Presentation] Viral suppression at week 4 exceeds the IL28B SNP for predicting SVR in pegylated interferon plus ribavirin combination therapy of genotype 1 infected patients with chronic hepatitis C (2011)
  • Author(s): 小瀬嗣子、巽智秀, 他
  • Organizer: 第62回米国肝臓学会
  • Place of Presentation: 米国サンフランシスコ市
  • Year and Date: 2011-11-06
• [Presentation] Estimation of liver fibrosis by VTTQ (Virtual Tissue Touch Quantification) in chronic liver disease : the usefulness of Vs/plt (2011)
  • Author(s): 山田涼子、巽智秀, 他
  • Organizer: 第62回米国肝臓学会
  • Place of Presentation: 米国サンフランシスコ市
  • Year and Date: 2011-11-06
• [Presentation] 持続的な肝細胞アポトーシスは肝発癌を誘導する (2011)
  • Author(s): 疋田隼人、巽智秀、竹原徹郎
  • Organizer: JDDW2011(第19回日本消化器関連学会週間、第53回消化器病学会大会、第15回肝臓学会大会、第9回消化器外科学会大会、第82回消化器内視鏡学会総会)
  • Place of Presentation: 福岡県福岡市
  • Year and Date: 2011-10-21
• [Presentation] 疎水化ポリγ-グルタミン酸ナノ粒子の癌抗原ペプチドワクチンにおけるアジュバントとしての有用性 (2011)
  • Author(s): 明田寛史、巽智秀、竹原徹郎(他17名)
  • Organizer: JDDW2011(第19回日本消化器関連学会週間、第15回肝臓学会大会)
  • Place of Presentation: 福岡県福岡市
  • Year and Date: 2011-10-21
• [Presentation] 持続的な肝細胞アポトーシスは肝発癌を誘導する (2011)
  • Author(s): 疋田隼人、巽智秀, 他
  • Organizer: 第53回消化器病学会大会
  • Place of Presentation: 福岡県福岡市
  • Year and Date: 2011-10-21
• [Presentation] IFNαはB型肝炎ウイルスのエンハンサー2の転写活性を阻害する (2011)
  • Author(s): 名和誉敏、巽智秀、竹原徹郎(他4名)
  • Organizer: JDDW2011(第19回日本消化器関連学会週間、第15回肝臓学会大会)
  • Place of Presentation: 福岡県福岡市
  • Year and Date: 2011-10-20
• [Presentation] 肝細胞特異的p53活性化マウスは肝線維化を自然発症する (2011)
  • Author(s): 小玉尚宏、巽智秀, 他
  • Organizer: 第15回肝臓学会大会
  • Place of Presentation: 福岡県福岡市
  • Year and Date: 2011-10-20
• [Presentation] IFNaはB型肝炎ウイルスのエンハンサー2の転写活性を阻害する (2011)
  • Author(s): 名和誉敏、巽智秀, 他
  • Organizer: 第15回肝臓学会大会
  • Place of Presentation: 福岡県福岡市
  • Year and Date: 2011-10-20
• [Presentation] Sorafenibは肝細胞癌のADAM9を抑制することで先天免疫応答を増強する (2011)
  • Author(s): 甲賀啓介、巽智秀, 他
  • Organizer: 肝癌研究会(第47回)
  • Place of Presentation: 静岡県静岡市
  • Year and Date: 2011-07-28
• [Presentation] 肝細胞におけるp53の活性化は肝に線維化を誘導する (2011)
  • Author(s): 小玉尚宏、竹原徹郎、巽智秀(他10名)
  • Organizer: 第47回肝臓学会総会
  • Place of Presentation: 東京
  • Year and Date: 2011-06-03
• [Presentation] Bak/ BaxダブルノックアウトマウスにおけるFasの活性化はカスパーゼ依存的な遅発性肝細胞死を誘導する (2011)
  • Author(s): 疋田隼人、巽智秀、竹原徹郎(他9名)
  • Organizer: 第47回肝臓学会総会
  • Place of Presentation: 東京
  • Year and Date: 2011-06-03
• [Presentation] 難治性C型肝炎に対するPeg-IFN/RBV併用療法の治療効果とIL28B遺伝子多型との関連について-多施設(OLF)共同研究- (2011)
  • Author(s): 小瀬嗣子、巽智秀, 他
  • Organizer: 肝臓学会総会(第47回)
  • Place of Presentation: 東京都港区
  • Year and Date: 2011-06-03
• [Presentation] 肝細胞におけるp53の活性化は肝に線維化を誘導する (2011)
  • Author(s): 小玉尚宏、巽智秀, 他
  • Organizer: 肝臓学会総会(第47回)
  • Place of Presentation: 東京都港区
  • Year and Date: 2011-06-03
• [Presentation] Bak/BaxダブルノックアウトマウスにおけるFasの活性化はカスパーゼ依存的な遅発性肝細胞死を誘導する (2011)
  • Author(s): 疋田隼人、巽智秀, 他
  • Organizer: 肝臓学会総会(第47回)
  • Place of Presentation: 東京都港区
  • Year and Date: 2011-06-03
• [Presentation] 炎症性サイトカインInterleukin-1βは肝細胞癌の先天免疫回避に関与する (2011)
  • Author(s): 巽智秀、竹原徹郎(他1名)
  • Organizer: 第47回肝臓学会総会
  • Place of Presentation: 東京
  • Year and Date: 2011-06-02
• [Presentation] C型慢性肝炎のPEG-IFN/ RBV併用治療における治療効果とC型肝炎ウイルス特異的細胞傷害性T細胞(CTL)免疫反応の関連 (2011)
  • Author(s): 巽智秀、竹原徹郎(他6名)
  • Organizer: 第47回肝臓学会総会
  • Place of Presentation: 東京
  • Year and Date: 2011-06-02
• [Presentation] 炎症性サイトカインInterleukin-1βは肝細胞癌の先天免疫回避に関与する (2011)
  • Author(s): 巽智秀, 他
  • Organizer: 肝臓学会総会(第47回)
  • Place of Presentation: 東京都港区
  • Year and Date: 2011-06-02
• [Presentation] C型慢性肝炎のPEG-IFN/RBV併用治療における治療効果とC型肝炎ウイルス特異的細胞傷害性T細胞(CTL)免疫反応の関連 (2011)
  • Author(s): 巽智秀, 他
  • Organizer: 肝臓学会総会(第47回)
  • Place of Presentation: 東京都港区
  • Year and Date: 2011-06-02
• [Presentation] オートファジーは肝癌のソラフェニブ抵抗性の一因である (2011)
  • Author(s): 清水聡、巽智秀, 他
  • Organizer: 肝臓学会総会(第47回)
  • Place of Presentation: 東京都港区
  • Year and Date: 2011-06-02
• [Presentation] A crucial role of hepatocyte p53 in liver fibrogenesis (2011)
  • Author(s): Kodama T, Takehara T, Tatsumi T, (他10名)
  • Organizer: DDW2011/ AGA/ AASLD
  • Place of Presentation: 米国シカゴ
  • Year and Date: 2011-05-11
• [Presentation] Signal transducer and activator of transcription 3 signaling in hepatocytes protects from liver injury and fibrosis during chronic cholestasis in mice (2010)
  • Author(s): 重川稔、巽智秀, 他
  • Organizer: 米国肝臓病学会
  • Place of Presentation: ボストン(アメリカ)
  • Year and Date: 2010-11-02
• [Presentation] The role of IFN-STAT1 signal transduction on inhibition of HCC development (2010)
  • Author(s): Hosui A, Takehara T, Tatsumi T(他9名)
  • Organizer: 第61回米国肝臓学会
  • Place of Presentation: 米国ボストン
  • Year and Date: 2010-10-30
• [Presentation] The role of IFN-STATI signal transduction on inhibition of HCC development (2010)
  • Author(s): 法水淳、巽智秀, 他
  • Organizer: 米国肝臓病学会
  • Place of Presentation: ボストン(アメリカ)
  • Year and Date: 2010-10-30
• [Presentation] Long-term effect of lamivudine treatment on the incidence of hepatocellular carcinoma in patients with hepatitis B virus. (2010)
  • Author(s): 黒川三佳、巽智秀, 他
  • Organizer: 米国肝臓病学会
  • Place of Presentation: ボストン(アメリカ)
  • Year and Date: 2010-10-30
• [Presentation] 肝細胞癌におけるADAMファミリーによる先天免疫応答制御機構の解析 (2010)
  • Author(s): 甲賀啓介、巽智秀, 他
  • Organizer: JDDW2010、第52回消化器病学会大会
  • Place of Presentation: 横浜市
  • Year and Date: 2010-10-15
• [Presentation] CD133陽性肝癌細胞のmetalloproteinaseによる制御 (2010)
  • Author(s): 巽智秀、竹原徹郎(他1名)
  • Organizer: JDDW2010(第18回日本消化器関連学会週間、第52回消化器病学会大会)
  • Place of Presentation: 神奈川県横浜市
  • Year and Date: 2010-10-14
• [Presentation] 血小板による肝線維化抑制機構の解明 (2010)
  • Author(s): 小玉尚宏、竹原徹郎、巽智秀(他8名)
  • Organizer: JDDW2010(第18回日本消化器関連学会週間、第52回消化器病学会大会)
  • Place of Presentation: 神奈川県横浜市
  • Year and Date: 2010-10-14
• [Presentation] CD133陽性肝癌細胞のmetalloproteinaseによる制御 (2010)
  • Author(s): 巽智秀, 他
  • Organizer: JDDW2010、第52回消化器病学会大会
  • Place of Presentation: 横浜市
  • Year and Date: 2010-10-14
• [Presentation] FGF-2の肝癌発癌抑制効果 (2010)
  • Author(s): 常松日奈子、巽智秀, 他
  • Organizer: JDDW2010、第52回消化器病学会大会
  • Place of Presentation: 横浜市
  • Year and Date: 2010-10-14
• [Presentation] 血小板による肝線維化抑制機構の解明 (2010)
  • Author(s): 小玉尚宏、巽智秀, 他
  • Organizer: JDDW2010、第52回消化器病学会大会
  • Place of Presentation: 横浜市
  • Year and Date: 2010-10-14
• [Presentation] α-fetoproteinによるNK細胞活性化抑制 (2010)
  • Author(s): 山本政司、巽智秀, 他
  • Organizer: JDDW2010、第52回消化器病学会大会
  • Place of Presentation: 横浜市
  • Year and Date: 2010-10-13
• [Presentation] CD133陽性肝細胞癌はmetalloproteinaseを制御しその生存に有利な環境を作る (2010)
  • Author(s): 巽智秀、竹原徹郎(他7名)
  • Organizer: 第69回癌学会総会
  • Place of Presentation: 大阪府大阪市
  • Year and Date: 2010-09-23
• [Presentation] Regulation of metalloproteinases in CD133 expressing human hepatocellular carcinoma cells (2010)
  • Author(s): 巽智秀, 他
  • Organizer: 癌学会総会(第69回)
  • Place of Presentation: 大阪市
  • Year and Date: 2010-09-23
• [Presentation] Sorafenibは肝細胞癌のADAM9は抑制することでMICAのsheddingを制御する (2010)
  • Author(s): 甲賀啓介、巽智秀、竹原徹郎(他6名)
  • Organizer: 第69回癌学会総会
  • Place of Presentation: 大阪府大阪市
  • Year and Date: 2010-09-21
• [Presentation] Sorafenib regulates the shedding of MICA by inhibiting ADAM9 in hepatocellular carcinoma (2010)
  • Author(s): 甲賀啓介、巽智秀, 他
  • Organizer: 癌学会総会(第69回)
  • Place of Presentation: 大阪市
  • Year and Date: 2010-09-21
• [Presentation] Peg-IFN/Ribavirin併用療法の肝発癌抑制効果について-多施設(OLF)共同研究- (2010)
  • Author(s): 小瀬嗣子、巽智秀, 他
  • Organizer: 肝臓学会総会 (第46回)
  • Place of Presentation: 山形市
  • Year and Date: 2010-05-28
• [Presentation] Red time PCR法を用いたHCV-RNA測定系におけるC型肝炎に対するPeg-IFN/RBV併用療法の治療効果予測 (2010)
  • Author(s): 小瀬嗣子、巽智秀, 他
  • Organizer: 肝臓学会総会 (第46回)
  • Place of Presentation: 山形市
  • Year and Date: 2010-05-28
• [Presentation] α-fetoproteinによる先天免疫活性化抑制機構の解析 (2010)
  • Author(s): 山本政司、巽智秀、竹原徹郎(他7名)
  • Organizer: 第46回肝臓学会総会
  • Place of Presentation: 山形県山形市
  • Year and Date: 2010-05-27
• [Presentation] α-fetoproteinによる先天免疫活性化抑制機構の解析 (2010)
  • Author(s): 山本政司、巽智秀, 他
  • Organizer: 肝臓学会総会 (第46回)
  • Place of Presentation: 山形市
  • Year and Date: 2010-05-27
• [Presentation] 長期経過観察を経て肝炎を発症したHBe抗原陽性無症候性HBVキャリアの1症例におけるHBV全塩基配列の啓示的変化とその病態的意義についての検討 (2010)
  • Author(s): 大川和良、巽智秀, 他
  • Organizer: 肝臓学会総会 (第46回)
  • Place of Presentation: 山形市
  • Year and Date: 2010-05-27
• [Presentation] Anti-cancer chemotherapy enhances NK sensitivity by inhibiting MICA ectodomain shedding in human hepatocellular carcinoma (2009)
  • Author(s): Kohga K, Tatsumi T, Takehara T(他4名)
  • Organizer: 第39回日本免疫学会
  • Place of Presentation: 大阪府大阪市
  • Year and Date: 2009-12-04
• [Presentation] Anti-cancer chemotherapy enhances NK sensitivity by inhibiting MICA ectodomain shedding in human hepatocellular carcinoma (2009)
  • Author(s): 甲賀啓介, 巽智秀, 他
  • Organizer: 日本免疫学会 (第39回)
  • Place of Presentation: 大阪国際会議場 (大阪府)
  • Year and Date: 2009-12-04
• [Presentation] α-fetoprotein impairs NK activity by inhibiting dendritic cell function (2009)
  • Author(s): Yamamoto M, Tatsumi T, Takehara T(他4名)
  • Organizer: 第39回日本免疫学会
  • Place of Presentation: 大阪府大阪市
  • Year and Date: 2009-12-03
• [Presentation] α-fetoprotein impairs NK activity by inhibiting dendritic cell function (2009)
  • Author(s): 山本政司, 巽智秀, 他
  • Organizer: 日本免疫学会 (第39回)
  • Place of Presentation: 大阪国際会議場 (大阪府)
  • Year and Date: 2009-12-03
• [Presentation] Lack of invariant natural killer T cells elicits liver inflammation and predisposes to liver fibrosis in mice fed with high-fat diet (2009)
  • Author(s): 西尾久美子, 巽智秀, 他
  • Organizer: 第60回米国肝臓学会
  • Place of Presentation: 米国ボストン市
  • Year and Date: 2009-11-03
• [Presentation] Interferon-α-signaling in natural killer cells is impaired in chronic hepatitis C virus infection (2009)
  • Author(s): Miyagi T, Takehara T, Tatsumi T, (他4名)
  • Organizer: 第60回米国肝臓学会
  • Place of Presentation: 米国ボストン
  • Year and Date: 2009-11-02
• [Presentation] Interferon-α-signaling in natural killer cells is impaired in chronic hepatitis C virus infection (2009)
  • Author(s): 宮城琢也, 巽智秀, 他
  • Organizer: 第60回米国肝臓学会
  • Place of Presentation: 米国ボストン市
  • Year and Date: 2009-11-02
• [Presentation] Thrombocytopenia deteriorates cholestasis-induced liver fibrosis in mice (2009)
  • Author(s): 小玉尚宏, 巽智秀, 他
  • Organizer: 第60回米国肝臓学会
  • Place of Presentation: 米国ボストン市
  • Year and Date: 2009-11-02
• [Presentation] Bcl-xL and Mcl-1 cooperate to maintain integrity of hepatocytes (2009)
  • Author(s): 疋田隼人, 巽智秀, 他
  • Organizer: 第60回米国肝臓学会
  • Place of Presentation: 米国ボストン市
  • Year and Date: 2009-11-01
• [Presentation] Combination therapy with PegIFNα-2b and ribavirin in chronic hepatitis C patients with normal ALT levels : Matched case-control study by propensity score (2009)
  • Author(s): 倉繁奈緒, 巽智秀, 他
  • Organizer: 第60回米国肝臓学会
  • Place of Presentation: 米国ボストン市
  • Year and Date: 2009-11-01
• [Presentation] Reducing drug doses in genotype 1 patients with chronic hepatitis C during treatment with pegylated interferon alfa-2b plus ribavirin delays the timing of HCVRNA negativity or prevents its attainment ; a propensity score-matched study (2009)
  • Author(s): 宋昌浩, 巽智秀, 他
  • Organizer: 第60回米国肝臓学会
  • Place of Presentation: 米国ボストン市
  • Year and Date: 2009-11-01
• [Presentation] ALT正常C型慢性肝炎に対するPegIFN/Rivavirin 併用療法の治療効果について-matched case-control study- (2009)
  • Author(s): 倉繁奈緒, 巽智秀, 他
  • Organizer: JDDW2009日本肝臓学会大会 (第13回)
  • Place of Presentation: 京都国際会議場 (京都府)
  • Year and Date: 2009-10-14
• [Presentation] The let7c family of micro RNAs negatively regulates Bcl-xL expression in human hepatocellular carcinoma (2009)
  • Author(s): 清水聡, 巽智秀, 他
  • Organizer: 癌学会総会 (第68回)
  • Place of Presentation: 横浜国際会議場 (神奈川県)
  • Year and Date: 2009-10-01
• [Presentation] 非アルコール性脂肪性肝炎病態形成におけるNKT細胞の関与 (2009)
  • Author(s): 宮城琢也, 巽智秀, 他
  • Organizer: 肝臓学会総会 (第45回)
  • Place of Presentation: 神戸国際会議場 (兵庫県)
  • Year and Date: 2009-06-05
• [Presentation] 血小板減少は胆汁鬱滞性肝障害における肝繊維化を増悪させる (2009)
  • Author(s): 小玉尚宏, 巽智秀, 他
  • Organizer: 肝臓学会総会 (第45回)
  • Place of Presentation: 神戸国際会議場 (兵庫県)
  • Year and Date: 2009-06-05
• [Presentation] 肝細胞癌におけるNK活性化レセプターリガンドMICA分泌(shedding)の分子機構 (2009)
  • Author(s): 甲賀啓介、竹原徹郎、巽智秀(他12名)
  • Organizer: 第45回肝臓学会総会
  • Place of Presentation: 兵庫県神戸市
  • Year and Date: 2009-06-04
• [Presentation] 血小板減少は胆汁鬱滞性肝障害における肝繊維化を増悪させる (2009)
  • Author(s): 小玉尚宏、竹原徹郎、巽智秀(他10名)
  • Organizer: 第45回肝臓学会総会
  • Place of Presentation: 兵庫県神戸市
  • Year and Date: 2009-06-04
• [Presentation] γ-PGAナノ粒子を用いた癌免疫療法の基礎的検討 (2009)
  • Author(s): 山口真二郎, 巽智秀, 他
  • Organizer: 肝臓学会総会 (第45回)
  • Place of Presentation: 神戸国際会議場 (兵庫県)
  • Year and Date: 2009-06-04
• [Presentation] 9年間の経過観察を経て肝炎を発症したHBe抗原陽性無症候性HBVキャリアの1症例における各種HBVマーカー全塩基は入れるの経時的検討 (2009)
  • Author(s): 大川和良, 巽智秀, 他
  • Organizer: 肝臓学会総会 (第45回)
  • Place of Presentation: 神戸国際会議場 (兵庫県)
  • Year and Date: 2009-06-04
• [Presentation] 肝細胞癌におけるNK活性化レセプターリガンドMICA分泌 (shedding) の分子機構 (2009)
  • Author(s): 甲賀啓介, 巽智秀, 他
  • Organizer: 肝臓学会総会 (第45回)
  • Place of Presentation: 神戸国際会議場 (兵庫県)
  • Year and Date: 2009-06-04
• [Presentation] Mcl-1とBcl-xLは肝細胞における主要なアポトーシス制御分子である (2009)
  • Author(s): 疋田隼人, 巽智秀, 他
  • Organizer: 肝臓学会総会 (第45回)
  • Place of Presentation: 神戸国際会議場 (兵庫県)
  • Year and Date: 2009-06-04
• [Presentation] 肝細胞癌におけるマイクロRNAによるBcl-xLの発現制御 (2009)
  • Author(s): 清水聡, 巽智秀, 他
  • Organizer: 肝臓学会総会 (第45回)
  • Place of Presentation: 神戸国際会議場 (兵庫県)
  • Year and Date: 2009-06-04
• [Presentation] 炎症性貧血は肝細胞STAT3が制御する (2009)
  • Author(s): 阪森亮太郎, 巽智秀, 他
  • Organizer: 肝臓学会総会 (第45回)
  • Place of Presentation: 神戸国際会議場 (兵庫県)
  • Year and Date: 2009-06-04
• [Presentation] 肝繊維化進展C型肝炎に対する pegIFN/RBV併用療法における治療効果関連因子の検討 (2009)
  • Author(s): 小瀬嗣子, 巽智秀, 他
  • Organizer: 消化器病学会総会 (第95回)
  • Place of Presentation: 北海道札幌市