Establishment of the novel diagnostic method for hepatic carcinoma via mass spectrometry

• Project/Area Number: 21590846
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Gastroenterology
• Research Institution: Kobe University
• Principal Investigator: SEO Yasushi 神戸大学, 医学部附属病院, 講師 (90362772)
• Project Period (FY): 2009 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2009: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: メタボロミクス / 質量分析計 / 肝がん / 早期診断 / メタボローム解析 / 肝臓がん

Research Abstract

In the cells along with pathological conditions, some metabolites are produced through the secretion of disease-related proteins and the protein degradation via each type of proteases, but the comprehensive study on these disease-specific low-molecular weight metabolites has not gotten remarkable performances yet. Therefore, we tried to discovery the novel cancer-specific biomarkers via the comprehensive analysis of the low-molecular weight metabolites derived from hepatic carcinomas. In addition, it was investigated whether the novel early diagnosing system can be actually used in the clinical practice.

Research Products

• [Journal Article] Short-term reductions in non-protein respiratory quotient and prealbumin can be associated with the long-term deterioration of liver function after transcatheter arterial chemoembolization in patients with hepatocellular carcinoma (2012)
  • Author(s): Saito Masaya, Seo Yasushi, Yano Yoshihiko, Miki Akira, Yoshida Masaru, Azuma Takeshi
  • Journal Title: J Gastroenterol Volume: (in press) Issue: 6 Pages: 704-714
  • DOI: 10.1007/s00535-012-0535-x
  • NAID: 10030802800
• [Journal Article] Short-term reductions in non-protein respiratory quotient and prealbumin can be associated with the long-term deterioration of liver function after transcatheter arterial chemoembolization in patients with hepatocellular carcinoma (2012)
  • Author(s): Masaya Saito
  • Journal Title: Journal of Gastroenterology Volume: (印刷中)(掲載確定)
  • Peer Reviewed
• [Journal Article] Activation of Aryl Hydrocarbon Receptor Induces Hepatic Steatosis via Upregulation of Fatty Acid Transport. (2010)
  • Author(s): Kawano Y, et al.
  • Journal Title: Arch Biochem Biophys. Volume: 15;504(2) Pages: 221-7
  • Peer Reviewed
• [Journal Article] A case of Budd-Chiari syndrome : Gd-EOB-DTPA-enhanced M R findings.
  • Author(s): Kitajima K, et al.
  • Journal Title: Magn Reson Imaging. Volume: (in press)
  • Peer Reviewed
• [Remarks]
  • URL: http://www.med.kobe-u.ac.jp/gi/index.htm
• [Remarks]
  • URL: http://www.med.kobe-u.ac.jp/gi/index.htm