The basic analysis of cell cycle association molecules by controlling the function aiming at application to liver regeneration treatment.
| Project/Area Number |
21590852
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Gastroenterology
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| Research Institution | Kumamoto University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
SASAKI Yutaka 熊本大学, 大学院・生命科学研究部, 教授 (70235282)
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| Co-Investigator(Renkei-kenkyūsha) |
NAKAYAMA Keiichi 九州大学, 生体防御医学研究所, 教授 (80291508)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2011: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2009: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 肝臓病学 / トランスクリプトーム / プロテオーム / 肝再生 / 細胞周期 |
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| Research Abstract |
We examined the possibility of the method through controlling a cell cycle in a liver regeneration promotion model using estradiol(E2) which can promote hepatocytes entering into G1 period from G0 period. Because of Ki67 positive rates in hepatocytes increased by the E2 dosage, we used E2 for the liver damage mouse and revealed that survival rate was different in a difference of the dosage time. This result suggested that there was participation in specific regeneration at the time of the liver damage, and the possibility of promote regeneration efficiently by the elucidation.
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Report
(4 results)
Research Products
(23 results)
