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Establishment of a treatment for advanced hepatocellular carcinoma using a tri-functional specific antibody

Research Project

Project/Area Number 21590853
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Gastroenterology
Research InstitutionSapporo Medical University

Principal Investigator

SASAKI Shigeru  札幌医科大学, 医学部, 講師 (10305229)

Co-Investigator(Kenkyū-buntansha) YAMAMOTO Hiroyuki  札幌医科大学, 医学部, 講師 (40332910)
IMAI Kohzoh  東京大学, 医科学研究所, 教授 (60117603)
SHINOMURA Yasuhisa  札幌医科大学, 医学部, 教授 (90162619)
Project Period (FY) 2009 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2011: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2010: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2009: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
Keywords肝臓学 / 肝癌 / 抗体治療 / 分子標的 / 分子改変 / 癌
Research Abstract

For advanced hepatocellular carcinoma has not been established at all treatments, we' ve been doing this research for the purpose of development of therapeutic antibodies as ideal therapeutic agents. We have shown that interferon(IFN)-α/βinduced the up-regulation of fibroblast growth factor receptor-1(FGFR-1) expression in several human liver cancer cells. Based on this result, we have created several anti-FGFR-1 monoclonal antibodies(MoAbs). We revealed that the efficacy of combined treatment with anti-FGFR-1 MoAb and interferon-α/βin human liver cancer cells in vitro and in vivo. The aim of this antibody therapy is more potent anti-cancer effects, we performed molecular alterations of this antibody, and established a tri-functional specific antibody in this study.

Report

(4 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • 2009 Annual Research Report
  • Research Products

    (10 results)

All 2011 2010 2009

All Journal Article (2 results) (of which Peer Reviewed: 2 results) Presentation (8 results)

  • [Journal Article] Interferon-α/βand anti-fibroblast growth factor receptor 1 monoclonal antibody suppress hepatic cancer cells in vitro and in vivo2011

    • Author(s)
      Sasaki S, Ishida T, Toyota M, Ota A, Suzuki H, Takaoka A, Yasui H, Yamamoto H, Takagi H, Maeda M, Seito T, Tsujisaki M, Shinomura Y, Imai K
    • Journal Title

      PLoS One

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Interferon-α/β and anti-fibroblast growth factor receptor 1 monoclonal antibody suppress hepatic cancer cells in vitro and in vivo2011

    • Author(s)
      Sasaki S., et al
    • Journal Title

      PLoS One

      Volume: 6 Issue: 5 Pages: e19618-e19618

    • DOI

      10.1371/journal.pone.0019618

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Presentation] 肝細胞がんに対するIFNおよび抗FGFR1抗体併用新規治療法の開発2011

    • Author(s)
      佐々木茂
    • Organizer
      第97回日本消化器病学会総会
    • Place of Presentation
      東京
    • Year and Date
      2011-05-13
    • Related Report
      2011 Final Research Report
  • [Presentation] 肝細胞がんに対するIFNおよび抗FGFR1抗体を用いた新規抗体治療法の開発2010

    • Author(s)
      佐々木茂
    • Organizer
      第48回日本癌治療学会学術集会
    • Place of Presentation
      京都
    • Year and Date
      2010-10-29
    • Related Report
      2011 Final Research Report
  • [Presentation] 肝細胞癌に対するIFNおよび抗FGFR1抗体を用いた新規抗体治療法の開発2010

    • Author(s)
      佐々木茂
    • Organizer
      第48回日本癌治療学会学術集会
    • Place of Presentation
      国立京都国際会館(京都)
    • Year and Date
      2010-10-29
    • Related Report
      2010 Annual Research Report
  • [Presentation] 肝細胞がんに対するIFNおよび抗FGFR1抗体を用いた新規抗体療法の開発2010

    • Author(s)
      佐々木茂
    • Organizer
      第47日本消化器免疫学会総会
    • Place of Presentation
      大津
    • Year and Date
      2010-07-08
    • Related Report
      2011 Final Research Report
  • [Presentation] 肝細胞がんに対するIFNおよび抗FGFR1抗体を用いた新規抗体治療法の開発2010

    • Author(s)
      佐々木茂
    • Organizer
      第47回日本消化器免疫学会総会
    • Place of Presentation
      大津プリンスホテル(大津)
    • Year and Date
      2010-07-08
    • Related Report
      2010 Annual Research Report
  • [Presentation] FGFR1を標的とした肝細胞がんに対する新規抗体治療法の開発2010

    • Author(s)
      佐々木茂
    • Organizer
      第26回日本DDS学会学術集会
    • Place of Presentation
      大阪
    • Year and Date
      2010-06-17
    • Related Report
      2011 Final Research Report
  • [Presentation] FGFR1を標的とした肝細胞がんに対する新規抗体治療法の開発2010

    • Author(s)
      佐々木茂
    • Organizer
      第26回日本DDS学会学術集会
    • Place of Presentation
      大阪国際交流センター(大阪)
    • Year and Date
      2010-06-17
    • Related Report
      2010 Annual Research Report
  • [Presentation] 消化器がんに対する改造抗体の作製2009

    • Author(s)
      佐々木茂
    • Organizer
      第25回日本DDS学会学術総会
    • Place of Presentation
      東京ドームホテル(東京)
    • Year and Date
      2009-07-03
    • Related Report
      2009 Annual Research Report

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Published: 2009-04-01   Modified: 2016-04-21  

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